Replacement of the α5 helix of Gα16 with Gαs-specific sequences enhances promiscuity of Gα 16 toward Gs-coupled receptors

Cellular Signalling

Volumn 16, Issue 1, 2004, Pages 51-62

  Hazari, Anjali ^b   Lowes, Vicki ^b   Chan, Jasmine H P ^b   Wong, Cecilia S S ^b   Ho, Maurice K C ^b   Wong, Yung H ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b NONE

Author keywords

Calcium mobilization; G protein; Phospholipase C; Receptor; Signal transduction

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOLIPASE C; PROTEIN G ALPHA 16; UNCLASSIFIED DRUG; BETA ADRENERGIC RECEPTOR; CALCIUM; G PROTEIN ALPHA 16; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CARBOXY TERMINAL SEQUENCE; CHIMERA; CONTROLLED STUDY; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; ANIMAL; CALCIUM SIGNALING; CELL STRAIN COS1; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; CALCIUM; CALCIUM SIGNALING; COS CELLS; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HETEROTRIMERIC GTP-BINDING PROTEINS; PHOSPHOLIPASE C; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 0242289449     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0898-6568(03)00097-4     Document Type: Article

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