Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model

Biology of Blood and Marrow Transplantation

Volumn 10, Issue 7, 2004, Pages 448-460

  Friedman, Jeff S ^a   Alpdogan, Onder ^b   van den Brink, Marcel R M ^b   Liu, Chen ^c   Hurwitz, Daniel ^d   Boyd, Ashleigh ^e   Kupper, Thomas S ^d   Burakoff, S J Steven J ^f  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging T cells; Cytokines; Effector activity; Graft versus host disease; T cell expansion

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; MEMBRANE ANTIGEN; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL AGING; CELL DEATH; CONTROLLED STUDY; CYTOLYSIS; DONOR; DOWNSTREAM PROCESSING; EFFECTOR CELL; FEMALE; GRAFT VERSUS HOST REACTION; HLA MATCHING; IMMUNOCOMPETENT CELL; IN VIVO STUDY; IRRADIATION; ISOGRAFT; LYMPHOCYTE HOMING; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PROGENY; PROTEIN EXPRESSION; RECIPIENT; SURVIVAL; T LYMPHOCYTE ACTIVATION; TARGET CELL;

AGING; ANIMALS; BONE MARROW TRANSPLANTATION; CELL AGING; CELL DIVISION; FEMALE; GRAFT VS HOST DISEASE; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 2942661632     PISSN: 10838791     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbmt.2004.03.005     Document Type: Article

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