Moderate exercise with a dietary vitamin C and E combination protects against streptozotocin-induced oxidative damage to the blood and improves fetal outcomes in pregnant rats

Clinical Chemistry and Laboratory Medicine

Volumn 42, Issue 5, 2004, Pages 511-517

  Naziroǧlu, Mustafa ^a,c   Şimşek, Mehmet ^b   Kutlu, Mehmet ^a  

^a FIRAT UNIVERSITY   (Turkey)

^b FIRAT UNIVERSITY   (Turkey)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Diabetes; Exercise; Oxidative stress; Pregnancy; Vitamins C and E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CATALASE; FREE RADICAL; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEMOGLOBIN; LIPID; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; SCAVENGER; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; BLOOD ANALYSIS; BLOOD SAMPLING; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC ANGIOPATHY; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; ENZYME ACTIVITY; ERYTHROCYTE COUNT; EXERCISE; FEMALE; FETUS; HOST RESISTANCE; LEUKOCYTE COUNT; LIPID PEROXIDATION; NONHUMAN; OUTCOMES RESEARCH; OXIDATIVE STRESS; PREGNANCY; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; THROMBOCYTE COUNT; TREADMILL;

ANIMALS; ASCORBIC ACID; BETA CAROTENE; BLOOD; BLOOD CELL COUNT; BLOOD GLUCOSE; BODY WEIGHT; CATALASE; DIABETES MELLITUS, EXPERIMENTAL; DIETARY SUPPLEMENTS; ERYTHROCYTES; FEMALE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; LITTER SIZE; MALONDIALDEHYDE; OXIDATIVE STRESS; PHYSICAL CONDITIONING, ANIMAL; PREGNANCY; RATS; RATS, WISTAR; VITAMIN A; VITAMIN E;

ANIMALIA; RATTUS NORVEGICUS;

EID: 2942639674     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2004.087     Document Type: Article

References (33)

1. Vanheest JL, Rodgers CD. Effects of exercise in diabetic rats before and during gestation on maternal and neonatal outcomes. Am J Physiol 1997;273:E727-33.
2. Palmer AM, Thomas CR, Gopaul N, Dhir S, Anggard EE, Poston L, et al. Dietary antioxidant supplementation reduces lipid peroxidation but impairs vascular function in small mesenteric arteries of the streptozotocin-diabetic rat. Diabetologia 1998;41:148-56.
3. Menegola E, Broccia ML, Prati M, Ricolfi R, Giavini E. Glutathione status in diabetes-induced embryopathies. Biol Neonate 1996;69:293-7.
4. Siman CM, Eriksson UJ. Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats. Diabetes 1997;46:1054-61.
5. Cederberg J, Siman CM, Eriksson UJ. Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy. Pediatric Res 2001;49:755-62.
6. Radak Z, Kaneko T, Tahara S, Nakamoto H, Ohno H, Sasvari M, et al. The effects of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: evidence for beneficial outcomes. Free Radic Biol Med 1999;27:69-74.
7. Kinalski M, Sledziewski A, Telejko B, Zarzycki W, Kinalska I. Antioxidant therapy and streptozotocin-induced diabetes in pregnant rats. Acta Diabetol 1999;36:113-7.
8. Cederberg J, Basu S, Eriksson UJ. Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy. Diabetologia 2001;44:744-66.
9. Damasceno DC, Volpato GT, Calderon IMP, Rudge MVC. Oxidative stress and diabetes in pregnant rats. Anim Reprod Sci 2002;72:235-44.
10. Lee DM, Hoffman WH, Carl GF, Khichi M, Cornwell PE. Lipid peroxidation and antioxidant vitamins prior to, during, and after correction of diabetic ketoacidosis. J Diabetes Complications 2002;16:294-300.
11. Atalay M, Laaksonen DE. Diabetes, oxidative stress and physical exercise. J Sports Sci Med 2002;1:1-14.
12. Halliwell B, Gutteridge JM. Free radicals in biology and medicine. Oxford, UK: Clarendon Press, 1996:1-543.
13. Packer L, Landvik S. Vitamin E in biological systems. In: Emerit I, Packer L, Auclair C, editor. Antioxidants in therapy and preventive medicine. New York: Plenum Press, 1990:93-104.
14. Naziroǧlu M, Cay M. Protective role of intraperitoneally administered vitamin E and selenium on the antioxidative defense mechanism in rats with diabetes induced streptozotocin. Biol Trace Elem Res 2001;79:149-59.
15. Naziroǧlu M, Şimşek M, Simsek H, Aydilek N, Ö zcan Z, Atilgan R. The effects of hormone replacement therapy with vitamin C and E combination on antioxidants levels and lipid profiles in postmenopausal women with type 2 diabetes. Clin Chem Acta 2004. In press.
16. Naziroǧlu M. Enhanced testicular antioxidant capacity in streptozotocin induced diabetic rats: protective role of vitamins C, E and selenium. Biol Trace Elem Res 2003;94:61-72.
17. Cay M, Naziroǧlu M, Şimşek H, Aydilek N, Aksakal M, Demirci M. Effects of intraperitoneally administered vitamin C on antioxidative defense mechanism in rats with diabetes induced by streptozotocin. Res Exp Med 2001;200:205-13.
18. Wilson R, Mansour MR, Stewart AD, Nimmo IA, Shepherd MJ, Riemersma RA. Lipid peroxidation in vivo is induced by exercise on a bicycle ergometer in athletes. Eur J Lipid Sci Technol 2001;103:350-4.
19. Mastaloudis A, Leonard SW, Traber MG. Oxidative stress in athletes during extreme endurance exercise. Free Radic Biol Med 2001;31:911-22.
20. Akova B, Sürmen-Gür E, Gür H, Dirican M, Sarandöl E, Küçükoǧlu S. Exercise induced oxidative stress and muscle performance in healthy women: role of vitamin E supplementation and endogenous oestradiol. Eur J Appl Physiol 2001; 84:141-7.
21. Ji LL, Stratman FW, Lardy HA. Enzymatic down regulation with exercise in rat skeletal muscle. Arch Biochem Biophys 1988;263:139-49.
22. Meydani M, Ewans W, Handelman G, Biddle L, Fielding RA, Meydani SN, et al. Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults. Am J Physiol 1993;264:R992-8.
23. Uriu-Hare JY, Keen CL, Applegate EA, Stern JS. The influence of moderate exercise in diabetic and normal pregnancy on maternal and fetal outcome in the rat. Life Sci 1989;45:647-54.
24. Placer ZA, Cushman L, Johnson BC. Estimation of product of lipid peroxidation (as malonyl dialdehyde) in biological fluids. Anal Biochem 1966;16:359-64.
25. Goth L. A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta 1991;196:143-52.
26. Goth L. Two cases of acatalasemia in Hungary. Clin Chim Acta 1992;207:155-8.
27. Sedlak J, Lindsay RHC. Estimation of total, protein bound and non-protein sulfhydryl groups in tissue with Ellmann's reagent. Anal Biochem 1968;25:192-205.
28. Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 1976;71:952-8.
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin- phenol reagent. J Biol Chem 1951;193:265-75.
30. Desai ID. Vitamin E analysis methods for animal tissues. Methods Enzymol 1984;105:138-47.
31. Suzuki J, Katoh N. A simple and cheap method for measuring vitamin A in cattle using only a spectrophotometer. Jpn J Vet Sci 1990;52:1281-3.
32. Viana M, Castro M, Barbas C, Herrera E, Bonet B. Effect of different doses of vitamin E on the incidence of malformations in pregnant diabetic rats. Ann Nutr Metab 2003;47:6-10.
33. Bowles DK, Torgan CE, Ebner S, Kehrer JP, Ivy JL, Starnes JW. Effects of acute, subacutemaximal exercise on skeletal muscle vitamin E. Free Radic Res Commun 1991;14:139-43.