Effects of exercise in diabetic rats before and during gestation on maternal and neonatal outcomes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 273, Issue 4 36-4, 1997, Pages

  Vanheest, Jaci L ^a   Rodgers, Carol D ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Glucose metabolism; Insulin dependent diabetes mellitus; Lipid metabolism; Teratology

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDURANCE; EXERCISE; FETUS GROWTH; GLUCOSE METABOLISM; INSULIN DEPENDENT DIABETES MELLITUS; LIPID METABOLISM; METABOLIC REGULATION; NONHUMAN; OUTCOMES RESEARCH; PREGNANCY; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TERATOLOGY;

EID: 0030667405     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.273.4.e727     Document Type: Article

References (16)

1. Aerts, L., and F. A. van Assche. Long-term effects of maternal hyperglycemia on islet function in offspring of diabetic pregnancies. In: Diabetes 1991. New York: Elsevier Science, 1991, p. 47-50.
2. Asplund, K. Effects of postnatal feeding on the functional maturation of pancreatic islet B-cells of neonatal rats. Diabetologia 8: 153-159, 1972.
3. Bober, R. Blood drawing from the tail artery of a rat. Lab. Anim. 17: 33-34, 1988.
4. Brownscheidle, C. M., V. Wootten, M. H. Mathieu, D. L. Davis, and I. A. Hofmann. The effects of maternal diabetes on fetal maturation and neonatal health. Metabolism 32: 148-155, 1983.
5. Chen, V., and C. D. Ianuzzo. Metabolic alterations in skeletal muscle of chronically streptozotocin diabetic rats. Arch. Biochem. Biophys. 217: 131-138, 1982.
6. Dall'aglio, E., H. Chang, C. B. Hollenback, C. E. Mondon, C. Sims, and G. E. Reaven. In vivo and in vitro resistance to maximal insulin-stimulated glucose disposal in insulin deficiency. Am. J. Physiol. 249 (Endocrinol. Metab. 12): E312-E316, 1983.
7. Eriksson, U. J., A. Andersson, S. Efendic, R. Elde, and C. Hellerstrom. Diabetes in pregnancy: effects of the foetal and newborn rat with particular regard to body weight, serum insulin concentration and pancreatic contents of insulin, glucagon and somatostatin. Acta Endocrinol. 94: 354-364, 1980.
8. Eriksson, U. J., and L. A. H. Borg. Embryonic malformations in a diabetic environment are caused by mitochondrial generation of free oxygen radicals (Abstract). Diabetologia 34, Suppl. 2: A5, 1991.
9. Freinkel, N. Banting Lecture 1980: of pregnancy and progeny. Diabetes 29: 1023-1035, 1980.
10. Gauguier, D., M. T. Bihoreau, A. Ktorza, M. F. Berthault, and L. Picon. Inheritance of diabetes mellitus as consequence of gestational hyperglycemia in rats. Diabetes 39: 734-739, 1990.
11. Goldman, A. S., and M. P. Goto. Biochemical basis of the diabetic embryopathy. Isr. J. Med. Sci. 27: 469-477, 1991.
12. Goodyear, L. J., M. F. Hirshman, E. D. Horton, S. M. Knutson, L. J. Wardzala, and E. S. Horton. Exercise training normalizes glucose metabolism in a rat model of impaired glucose tolerance. Metabolism 40: 455-464, 1991.
13. Goodyear, L. J., M. F. Hirshman, S. M. Knutson, E. D. Horton, and E. S. Horton. Effect of exercise training on glucose homeostasis in normal and insulin-deficient diabetic rats. J. Appl. Physiol. 65: 844-851, 1988.
14. Grill, V., B. Johansson, P. Jalkanen, and U. J. Eriksson. Influence of severe diabetes mellitus early in pregnancy in the rat: effects on insulin sensitivity and insulin secretion in the offspring. Diabetologia 34: 373-378, 1991.
15. Hollingsworth, D. R. Alterations of maternal metabolism in normal and diabetic pregnancies: differences in insulin-dependent, non-insulin-dependent, and gestational diabetes. Am. J. Obstet. Gynecol. 146: 417-429, 1983.
16. Kervran, A., M. Guillaume, and A. Jost. The endocrine pancreas of the fetus from diabetic pregnant rat. Diabetologia 15: 387-393, 1978.