Regulation of aminopeptidase A expression in cervical carcinoma: Role of tumor-stromal interaction and vascular endothelial growth factor

Laboratory Investigation

Volumn 84, Issue 5, 2004, Pages 639-648

  Suganuma, Takayasu ^a   Ino, Kazuhiko ^a   Shibata, Kiyosumi ^a   Nomura, Seiji ^a   Kajiyama, Hiroaki ^a   Kikkawa, Fumitaka ^a   Tsuruoka, Nobuo ^b   Mizutani, Shigehiko ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SUNTORY LTD   (Japan)

Author keywords

Aminopeptidase A; Angiotensin II; Cervical carcinoma; Fibroblast; Invasion; VEGF

Indexed keywords

ANGIOTENSIN; GLUTAMYL AMINOPEPTIDASE; VASCULOTROPIN; ANGIOTENSIN II; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INVASION; COCULTURE; CONTROLLED STUDY; FEMALE; FIBROBLAST CULTURE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX CARCINOMA; UTERINE CERVIX CARCINOMA IN SITU; WESTERN BLOTTING; ANIMAL; CANCER TRANSPLANTATION; CELL DIVISION; CULTURE MEDIUM; DRUG ANTAGONISM; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE; UTERINE CERVIX TUMOR; XENOGRAFT;

ANGIOTENSIN II; ANIMALS; CELL DIVISION; CELL LINE, TUMOR; CERVICAL INTRAEPITHELIAL NEOPLASIA; CULTURE MEDIA, CONDITIONED; FEMALE; GENE EXPRESSION; GLUTAMYL AMINOPEPTIDASE; HUMANS; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; UTERINE CERVICAL NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 2942628397     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3700072     Document Type: Article

References (45)

1. Kenny AJ, O'Hare MJ, Gusterson BA. Cell-surface peptidases as modulators of growth and differentiation. Lancet 1989;2:785-787.
2. Shipp MA, Look AT. Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key!. Blood 1993;82:1052-1070.
3. Papandreou CN, Usmani B, Geng Y, et al. Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression. Nat Med 1998;4:50-57.
4. Suzuki T, Kikkawa F, Ino K, et al. Imbalance between neutral endopeptidase 24.11 and endothelin-1 expression in human endometrial carcinoma. Oncology 2001;60:258-267.
5. Wesley UV, Albino AP, Tiwari S, et al. A role for dipeptidyl peptidase IV in suppressing the malignant phenotype of melanocytic cells. J Exp Med 1999;190:311-322.
6. Kajiyama H, Kikkawa F, Khin EE, et al. Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells. Cancer Res 2003;63:2278-2283.
7. Saiki I, Fujii H, Yoneda J, et al. Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation. Int J Cancer 1993;54:137-143.
8. Ino K, Goto S, Okamoto T, et al. Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity. Jpn J Cancer Res 1994;85:927-933.
9. Glenner GG, McMillan PJ, Folk JE. A mammalian peptidase specific for the hydrolysis of N-terminal α-L-glutamyl and aspartyl residues. Nature 1962;194:867.
10. Wu Q, Lahti JM, Air GM, Burrows PD, Cooper MD. Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family. Proc Natl Acad Sci USA 1990;87:993-997.
11. Nanus DM, Engelstein D, Gastl GA, et al. Molecular cloning of the human kidney differentiation antigen gp 160: human aminopeptidase A. Proc Natl Acad Sci USA 1993;90:7069-7073.
12. Healy DP, Wilk S. Localization of immunoreactive glutamyl aminopeptidase in rat brain. II. Distribution and correlation with angiotensin II. Brain Res 1993;606:295-303.
13. Schlingemann RO, Oosterwijk E, Wesseling P, et al. Aminopeptidase A is a constituent of activated pericytes in angiogenesis. J Pathol 1996;179:436-442.
14. Song L, Ye M, Troyanovskaya M, et al. Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization. Am J Physiol 1994;267:F546-F557.
15. Mizutani S, Akiyama H, Kurauchi O, et al. In vitro degradation of angiotensin II (A-II) by human placental subcellular fractions, pregnancy sera and purified placental aminopeptidases. Acta Endocrinol 1985;110:135-139.
16. Mizutani S, Okano K, Hasegawa E, et al. Aminopeptidase A in human placenta. Biochem Biophys Acta 1981;678:168-170.
17. Mizutani S, Tomoda Y. Effects of placental proteases on maternal and fetal blood pressure in normal pregnancy and preeclampsia. Am J Hypertens 1996;9:591-597.
18. Finstad CL, Cordon-Cardo C, Bander NH, et al. Specificity analysis of mouse monoclonal antibodies defining cell surface antigens of human renal cancer. Proc Natl Acad Sci USA 1985;82:2955-2959.
19. Nanus DM, Bogenrieder T, Papandreou CN, et al. Aminopeptidase A expression and enzymatic activity in primary human renal cancers. Int J Oncol 1998;13:261-267.
20. Ino K, Nagasaka T, Okamoto T, et al. Expression of aminopeptidase A in human gestational choriocarcinoma cell lines and tissues. Placenta 2000;21:63-72.
21. Fujimura H, Ino K, Nagasaka T, et al. Aminopeptidase A expression in cervical neoplasia and its relationship to neoplastic transformation and progression. Oncology 2000;58:342-352.
22. Shekhar MP, Werdell J, Santner SJ, et al. Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression. Cancer Res 2001;61:1320-1326.
23. Dong Z, Nemeth JA, Cher ML, et al. Differential regulation of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression in co-cultures of prostate cancer and stromal cells. Int J Cancer 2001;93:507-515.
24. Wang TN, Albo D, Tuszynski GP. Fibroblasts promote breast cancer cell invasion by upregulating tumor matrix metalloproteinase-9 production. Surgery 2002;132:220-225.
25. Boyd RS, Balkwill FR. MMP-2 release and activation in ovarian carcinoma: the role of fibroblasts. Br J Cancer 1999;80:315-321.
26. Ino K, Uehara C, Kikkawa F, et al. Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway. J Clin Endocrinol Metab 2003;88:3973-3982.
27. Kajiyama H, Kikkawa F, Maeda O, et al. Increased expression of dipeptidyl peptidase IV in human mesothelial cells by malignant ascites from ovarian carcinoma patients. Oncology 2002;63:158-165.
28. Ko K, Yazumi S, Yoshikawa K, et al. Activation of fibroblast-derived matrix metalloproteinase-2 by colon-cancer cells in non-contact co-cultures. Int J Cancer 2000;87:165-171.
29. Shibata K, Kikkawa F, Nawa A, et al. Increased matrix metalloproteinase-9 activity in human ovarian cancer cells cultured with conditioned medium from human peritoneal tissue. Clin Exp Metastasis 1997;15:612-619.
30. Kikkawa F, Nawa A, Shibata K, et al. The different stimulatory effect of normal tissues on the secretion of matrix metalloproteinases and their inhibitors by human ovarian cancer cells. Anticancer Res 1998;18:4323-4328.
31. Bogenrieder T, Finstad CL, Freeman RH, et al. Expression and localization of aminopeptidase A, aminopeptidase N, and dipeptidyl peptidase IV in benign and malignant human prostate tissue. Prostate 1997;33:225-232.
32. Riemann D, Kehlen A, Thiele K, et al. Induction of aminopeptidase N/CD13 on human lymphocytes after adhesion to fibroblast-like synoviocytes, endothelial cells, epithelial cells, and monocytes/macrophages. J Immunol 1997;158:3425-3432.
33. Welch PA, Burrows PD, Namen A, et al. Bone marrow stromal cells and interleukin-7 induce coordinate expression of the BP-1/6C3 antigen and pre-B cell growth. Int Immunol 1990;2:697-705.
34. Wang J, Walker H, Lin Q, et al. The mouse BP-1 gene: structure, chromosomal localization, and regulation of expression by type I interferons and interleukin-7. Genomics 1996;33:167-176.
35. Kehlen A, Gohring B, Langner J, et al. Regulation of the expression of aminopeptidase A, aminopeptidase N/ CD13 and dipeptidyl peptidase IV/CD26 in renal carcinoma cells and renal tubular epithelial cells by cytokines and cAMP-increasing mediators. Clin Exp Immunol 1998;111:435-441.
36. Juillerat-Jeanneret L, Lohm S, Hamou MF, et al. Regulation of aminopeptidase A in human brain tumor vasculature: evidence for a role of transforming growth factor-β. Lab Invest 2000;80:973-980.
37. Miyashita H, Yamazaki T, Akada T, et al. A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis. Blood 2002;99:3241-3249.
38. Touyz RM, Deng LY, He G, et al. Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases. J Hypertens 1999;17:907-916.
39. Nadal JA, Scicli GM, Carbini LA, et al. Angiotensin II stimulates migration of retinal microvascular pericytes: involvement of TGF-β and PDGF-BB. Am J Physiol Heart Circ Physiol 2002;282:H739-H748.
40. Fujii H, Nakajima M, Saiki I, et al. Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13. Clin Exp Metastasis 1995;13:337-344.
41. Fujimoto J, Sakaguchi H, Hirose R, et al. Expression of vascular endothelial growth factor (VEGF) and its mRNA in uterine cervical cancers. Br J Cancer 1999;80:827-833.
42. Dobbs SP, Hewett PW, Johnson IR, et al. Angiogenesis is associated with vascular endothelial growth factor expression in cervical intraepithelial neoplasia. Br J Cancer 1997;76:1410-1415.
43. Tokumo K, Kodama J, Seki N, et al. Different angiogenic pathways in human cervical cancers. Gynecol Oncol 1998;68:38-44.
44. Cheng WF, Chen CA, Lee CN, et al. Vascular endothelial growth factor in cervical carcinoma. Obstet Gynecol 1999;93:761-765.
45. Guidi AJ, Abu-Jawdeh G, Berse B, et al. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J Natl Cancer Inst 1995;87:1237-1245.