A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis

Blood

Volumn 99, Issue 9, 2002, Pages 3241-3249

  Miyashita, Hiroki ^a,b   Yamazaki, Tohru ^a,b   Akada, Tetsuya ^a,b   Niizeki, Osamu ^a,b   Ogawa, Minetaro ^a,b   Nishikawa, Shin Ichi ^a,b   Sato, Yasufumi ^a,b  

^a TOHOKU UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; ANTISENSE OLIGODEOXYNUCLEOTIDE; PUROMYCIN; RECOMBINANT PROTEIN; VASCULOTROPIN;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME SPECIFICITY; GENE INDUCTION; HYBRIDIZATION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0036565887     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.9.3241     Document Type: Article

References (47)

1. Mechanisms of angiogenesis
2. Signaling vascular morphogenesis and maintenance
3. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
4. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
5. Role of the Fit-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
6. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
7. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
8. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
9. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
10. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
11. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development
12. Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice
13. TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
14. Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development
15. Edg-1, the G protein-coupled receptor for sphingosine1-phosphate, is essential for vascular maturation
16. Molecular and biological properties of vascular endothelial growth factor
17. Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies
18. In vitro differentiation of embryonic stem cells
19. Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps
20. Induction of vasculogenesis and hematopoiesis in vitro
21. Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages
22. Maturation of embryonic stem cells into endothelial cells in an in vitro model of vasculogenesis
23. Endothelial cells create a hematopoietic inductive microenvironment preferential to erythropoiesis in the mouse spleen
24. Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells
25. Autocrine activities of basic fibroblast growth factor: Regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis
26. Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31
27. Significant roles of inducible cyclooxygenase (COX)-2 in angiogenesis in rat sponge implants
28. Introduction: Family M1 of membrane alanyl aminopeptidase
29. Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells
30. Molecular characterization of a puromycin-insensitive leucyl-specific aminopeptidase, PILSAP
31. Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: An autocrine mechanism contributing to angiogenesis
32. Aminopeptidases: Structure and function
33. Aminopeptidase N
34. Structure and function of aminopeptidase A
35. Identification of the thyrotropin-releasing-hormone-degrading ectoenzyme as a metallopeptidase
36. Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles
37. Aminopeptidase-B in the rat testes: Isolation, functional properties and cellular localization in the seminiferous tubules
38. Leukotriene A4 hydrolase in the human lung: Inactivation of the enzyme with leukotriene A4 isomers
39. Puromycin-sensitive aminopeptidase: Sequence analysis, expression, and functional characterization
40. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis
41. Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: A new type of proteolytic enzyme
42. Eukaryotic methionyl aminopeptidases: Two classes of cobalt-dependent enzymes
43. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth
44. Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470)
45. Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin
46. Selective inhibition of endothelial cell proliferation by fumagillin is not due to differential expression of methionine aminopeptidases
47. Multiple developmental roles VEGF suggested by a LacZ-tagged allele