GBP-5 splicing variants: New guanylate-binding proteins with tumor-associated expression and antigenicity

Journal of Investigative Dermatology

Volumn 122, Issue 6, 2004, Pages 1510-1517

  Fellenberg, Friederike ^a   Hartmann, Tanja B ^a   Dummer, Reinhard ^b   Usener, Dirk ^a   Schadendorf, Dirk ^a   Eichmüller, Stefan ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

CTCL; GTPases; Interferon; Isoprenylation; Melanoma; Tumor immunology

Indexed keywords

ANTIBODY; GAMMA INTERFERON; GUANINE BINDING PROTEIN 5; GUANINE BINDING PROTEIN 5A; GUANINE BINDING PROTEIN 5B; GUANINE BINDING PROTEIN 5TA; GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANTIGENICITY; ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGENICITY; ISOPRENYLATION; MELANOMA CELL; MONOCYTE; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; T CELL LYMPHOMA; WESTERN BLOTTING;

EID: 2942616852     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.22613.x     Document Type: Article

References (44)

1. Ahmadian MR, Zor T, Vogt D, Kabsch W, Selinger Z, Wittinghofer A, Scheffzek K: Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proc Natl Acad Sci USA 96:7065-7070, 1999
2. Anderson SL, Carton JM, Lou J, Xing L, Rubin BY: Interferon-induced guanylate binding protein-1 (GBP-1) mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus. Virology 256:8-14, 1999
3. Boehm U, Guethlein L, Klamp T, et al: Two families of GTPases dominate the complex cellular response to IFN-gamma. J Immunol 161:6715-6723, 1998
4. Bourne HR, Sanders DA, McCormick F: The GTPase superfamily: Conserved structure and molecular mechanism. Nature 349:117-127, 1991
5. Burg G, Kempf W, Häffner A, et al: Cutaneous lymphomas. Curr Probl Dermatol 9:137-204, 1997
6. Casey PJ: Mechanisms of protein prenylation and role in G protein function. Biochem Soc Trans 23:161-166, 1995
7. Cheng YS, Becker-Manley MF, Chow TP, Horan DC: Affinity purification of an interferon-induced human guanylate-binding protein and its characterization. J Biol Chem 260:15834-15839, 1985
8. Cheng Y, Patterson C, Staeheli P: Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP. Mol Cell Biol 11:4717-4725, 1991
9. Clarke S: Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Annu Rev Biochem 61:355-386, 1992
10. Dippel E, Klemke CD, Goerdt S: Current status of cutaneous T-cell lymphoma: Molecular diagnosis, pathogenesis, therapy and future directions. Onkologie 26:477-483, 2003
11. Dummer R, Döbbeling U, Geertsen R, Willers J, Burg G, Pavlovic J: Interferon resistance of cutaneous T-cell lymphoma-derived clonal T-helper 2 cells allows selective viral replication. Blood 97:523-527, 2001
12. Dummer R, Häffner A, Hess M, Burg G: A rational approach to the therapy of cutaneous T-cell lymphomas. Onkologie 19:226-230, 1996
13. Duvic M, Cather JC: Emerging new therapies for cutaneous T-cell lymphoma. Dermatol Clin 18:147-156, 2000
14. Eichmüller S: Towards defining specific antigens for cutaneous lymphomas. Onkologie 25:448-454, 2002
15. Eichmüller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D: Serological detection of cutaneous T-cell lymphoma-associated antigens. Proc Natl Acad Sci USA 98:629-634, 2001
16. Garbe C, Krasagakis K: Effects of interferons and cytokines on melanoma cells. J Invest Dermatol 100:239s-244s, 1993
17. Gorbacheva VY, Lindner D, Sen GC, Vestal DJ: The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation. J Biol Chem 277:6080-6087, 2002
18. Guenzi E, Topolt K, Cornali E, et al: The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines. EMBO J 20:5568-5577, 2001
19. Hancock JF, Magee AI, Childs JE, Marshall CJ: All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57:1167-1177, 1989
20. Hartmann TB, Thiel D, Dummer R, Schadendorf D, Eichmüller S: SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. Br J Dermatol 150:252-258, 2004
21. Kaltoft K, Bisballe S, Dyrberg T, Boel E, Rasmussen PB, Thestrup-Pedersen K: Establishment of two continuous T-cell strains from a single plaque of a patient with mycosis fungoides. In Vitro Cell Dev Biol 28A:161-167, 1992
22. Kaltoft K, Bisballe S, Rasmussen HF, Thestrup-Pedersen K, Boehncke WH, Volker H, Sterry W: C-type particles are inducible in Se-Ax, a continuous T-cell line from a patient with Sezary's syndrome. Arch Dermatol Res 280:264-267, 1988
23. Kikuchi M, Nakao M, Inoue Y, Matsunaga K, Shichijo S, Yamana H, Itoh K: Identification of a SART-1-derived peptide capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes. Int J Cancer 81:459-466, 1999
24. Luan Z, Zhang Y, Liu A, Man Y, Cheng L, Hu G: A novel GTP-binding protein hGBP3 interacts with NIK/HGK. FEBS Lett 530:233-238, 2002
25. Macaluso M, Russo G, Cinti C, Bazan V, Gebbia N, Russo A: Ras family genes: An interesting link between cell cycle and cancer. J Cell Physiol 192: 125-130, 2002
26. Maier T, Tun-Kyi A, Tassis A, Jungius KP, Burg G, Dummer R, Nestle FO: Vaccination of cutaneous T-cell lymphoma patients using intranodal injection of autologous tumor lysate pulsed dendritic cells. Blood, prepublished online, 2003.
27. Nantais DE, Schwemmle M, Stickney JT, Vestal DJ, Buss JE: Prenylation of an interferon-gamma-induced GTP-binding protein: The human guanylate binding protein, huGBP1. J Leukoc Biol 60:423-431, 1996
28. Neun R, Richter MF, Staeheli P, Schwemmle M: GTPase properties of the interferon-induced human guanylate-binding protein 2. FEBS Lett 390:69-72, 1996
29. Nguyen TT, Hu Y, Widney DP, Mar RA, Smith JB: Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro. J Interferon Cytokine Res 22:899-909, 2002
30. Patrone L, Damore MA, Lee MB, Malone CS, Wall R: Genes expressed during the IFN gamma-induced maturation of pre-B cells. Mol Immunol 38:597-606, 2002
31. Prakash B, Renault L, Praefcke GJ, Herrmann C, Wittinghofer A: Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism. EMBO J 19:4555-4564, 2000
32. Rosenberg SA: A new era for cancer immunotherapy based on the genes that encode cancer. Immunity 10:281-287, 1999
33. Rosenberg SA: Progress in the development of immunotherapy for the treatment of patients with cancer. J Intern Med 250:462-475, 2001
34. Schafer WR, Kim R, Sterne R, Thorner J, Kim SH, Rine J: Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. Science 245:379-385, 1989
35. Scheffzek K, Ahmadian MR, Wittinghofer A: GTPase-activating proteins: Helping hands to complement an active site. Trends Biochem Sci 23:257-262, 1998
36. Schwemmle M, Staeheli P: The interferon-induced 67-kDa guanylate-binding protein (hGBP1) is a GTPase that converts GTP to GMP. J Biol Chem 269:11299-11305, 1994
37. Sehr P, Zumbach K, Pawlita M: A generic capture ELISA for recombinant proteins fused to glutathione S-transferase: Validation for HPV serology. J Immunol Methods 253:153-162, 2001
38. Shichijo S, Nakao M, Imai Y, et al: A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes. J Exp Med 187:277-288, 1998
39. Smythe E: Direct interactions between rab GTPases and cargo. Mol Cell 9:205-206, 2002
40. Stickney JT, Buss JE: Murine guanylate-binding protein: Incomplete geranylgeranyl isoprenoid modification of an interferon-gamma-inducible guanosine triphosphate-binding protein. Mol Biol Cell 11:2191-2200, 2000
41. Strehlow I, Lohmann Matthes ML, Decker T: The interferon-inducible GBP1 gene: Structure and mapping to human chromosome 1. Gene 144:295-299, 1994
42. Usener D, Gerhardt A, Schadendorf D, Eichmüller S: Sero-reactivity against MAGE-A and LAGE-1 proteins in melanoma patients. Br J Dermatol 149:282-288, 2003
43. Weber F, Haller O, Kochs G: MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes. J Virol 74: 560-563, 2000
44. Willemze R, Kerl H, Sterry W, et al: EORTC classification for primary cutaneous lymphomas: A proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. Blood 90:354-371, 1997