The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines

EMBO Journal

Volumn 20, Issue 20, 2001, Pages 5568-5577

  Guenzi, Eric ^a   Töpolt, Kristin ^a   Cornali, Emmanuelle ^b,c   Lubeseder Martellato, Clara ^a   Jörg, Anita ^a   Matzen, Kathrin ^a   Zietz, Christian ^d   Kremmer, Elisabeth ^a   Nappi, Filomena ^e   Schwemmle, Martin ^f   Hohenadl, Christine ^g   Barillari, Giovanni ^e   Tschachler, Erwin ^h   Monini, Paolo ^e   Ensoli, Barbara ^e   Stürzl, Michael ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c Ingenium Pharmaceuticals AG   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

^e ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^f UNIVERSITY OF FREIBURG   (Germany)

^g Austrian Nordic Biotherapeutics   (Austria)

^h Universitatsklinik fur Dermatologie   (Austria)

Author keywords

Angiogenesis; Interferon; Interleukin; TNF; VEGF

Indexed keywords

GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN 1; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; MEDIATOR RELEASE; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN DOMAIN;

APOPTOSIS; CELL ADHESION; CELL DIVISION; CELLS, CULTURED; DNA, ANTISENSE; DNA-BINDING PROTEINS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GTP-BINDING PROTEINS; HIV INFECTIONS; HUMANS; INFLAMMATION MEDIATORS; INTERFERON TYPE II; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM PROTEINS; PROTEIN ISOPRENYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SARCOMA, KAPOSI; SKIN NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS; UMBILICAL VEINS;

EID: 17944366368     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.20.5568     Document Type: Article

References (49)

1. Interferon-induced guanylate binding protein-1 (GBP-1) mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus
2. Interferon-inducible gene expression in HL-60 cells: Effects of the state of differentiation
3. Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines
4. Angiogenesis in cancer and other diseases
5. Effects of inflammatory cytokines and phorbol esters on the adhesion of U937 cells, a human monocyte-like cell line, to endothelial cell monolayers and extracellular matrix proteins
6. Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP
7. Endothelial cells in physiology and in the pathophysiology of vascular disorders
8. Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma
9. Interleukin 1 is an autocrine regulator of human endothelial cell growth
10. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice
11. Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma
12. Biology of Kaposi's sarcoma
13. Dual role of tumor necrosis factor-α in angiogenesis
14. Gene transfer of IFN-γ into established brain tumors represses growth by antiangiogenesis
15. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
16. γ-Interferon produced by CD8+ T cells infiltrating Kaposi's sarcoma induces spindle cells with angiogenic phenotype and synergy with human immunodeficiency virus-1 Tat protein: An immune response to human herpesvirus-8 infection?
17. Angiogenic factors
18. Tumor necrosis factor type α, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo
19. Inhibition of endothelial cell proliferation by γ-interferon
20. Growth regulation of cultured endothelial cells by inflammatory cytokines: Mitogenic, anti-proliferative and cytotoxic effects
21. Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium
22. Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: The role of angiogenic factors
23. Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents
24. Vascular permeability factor, an endothelial cell mitogen related to PDGF
25. VEGF stimulates expression of ICAM-1, VCAM-1 and E-selectin through nuclear factor-κB activation in endothelial cells
26. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction
27. VEGF increases retinal vascular ICAM-1 expression in vivo
28. Factors influencing blood supply in wound granuloma quantitated by a new in vivo technique
29. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium
30. Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus
31. Tumor necrosis factor α-induced angiogenesis depends on in situ platelet-activating factor biosynthesis
32. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
33. Prenylation of an interferon-γ-induced GTP-binding protein: The human guanylate binding protein, huGBP1
34. Interaction of interleukin-1 and interferon-γ on fibroblast growth factor-induced angiogenesis
35. A functional GTP-binding motif is necessary for antiviral activity of Mx proteins
36. Nucleotide-binding characteristics of human guanylate-binding protein 1 (hGBP1) and identification of the third GTP-binding motif
37. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins
38. Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism
39. Inflammatory cytokines induce endothelial cells to produce and release basic fibroblast growth factor and to promote Kaposi's sarcoma-like lesions in nude mice
40. Regulation of guanylate-binding protein expression in interferon-γ-treated human epidermal keratinocytes and squamous cell carcinoma cells
41. Tumor necrosis factor inhibits the proliferation of cultured capillary endothelial cells
42. Activation of transcription by IFN-γ: Tyrosine phosphorylation of a 91-kD DNA binding protein
43. Identification of interleukin-1 and platelet-derived growth factor-B as major mitogens for the spindle cells of Kaposi's sarcoma: A combined in vitro and in vivo analysis
44. Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells
45. Human herpes-virus-8 and Kaposi's sarcoma: Relationship with the multistep concept of tumorigenesis
46. Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: Possible involvement of TNFα and IL-α
47. Functional diversity in the dynamin family
48. Fibroblast growth factor gene expression in AIDS-Kaposi's sarcoma detected by in situ hybridization
49. Pulse treatment of human vascular endothelial cells with high doses of tumor necrosis factor and interferon-γ results in simultaneous synergistic and reversible effects on proliferation and morphology