Receptor binding thermodynamics as a tool for linking drug efficacy and affinity

Farmaco

Volumn 53, Issue 4, 1998, Pages 249-254

  Borea, Pier Andrea ^a   Varani, Katia ^a   Gessi, Stefania ^a   Gilli, Paola ^b   Dalpiaz, Alessandro ^c  

^a UNIVERSITY OF FERRARA   (Italy)

^b Dipartimento di Chimica   (Italy)

^c Dipartimento di Scienze Farmaceutiche   (Italy)

Author keywords

Agonist antagonist discrimination; Binding thermodynamics; Enthalpy entropy compensation; G protein coupled receptors; Ligand gated ion channel receptors

Indexed keywords

DRUG; GUANINE NUCLEOTIDE BINDING PROTEIN; ION CHANNEL;

BINDING AFFINITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; ENTHALPY; ENTROPY; NONHUMAN; RECEPTOR BINDING; SIGNAL TRANSDUCTION; THERMODYNAMICS;

GTP-BINDING PROTEINS; ION CHANNEL GATING; RECEPTORS, CELL SURFACE; THERMODYNAMICS;

EID: 0031819840     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(98)00017-2     Document Type: Conference Paper

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