Acrylonitrile irreversibly inactivates glyceraldehyde-3-phosphate dehydrogenase by alkylating the catalytically active cysteine 149

Chemico-Biological Interactions

Volumn 140, Issue 3, 2002, Pages 279-291

  Campian, E Cristian ^a   Cai, Jian ^a   Benz, Frederick W ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Acrylonitrile; Acute toxicity; Covalent binding; Enzyme inhibition; Glyceraldehyde 3 phosphate dehydrogenase

Indexed keywords

ACRYLONITRILE; ADENOSINE TRIPHOSPHATE; CYANIDE; CYSTEINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ALKYLATION; ANIMAL TISSUE; ARTICLE; BRAIN; CATALYSIS; CONTROLLED STUDY; DESORPTION; ENERGY YIELD; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SYNTHESIS; GLYCOLYSIS; IONIZATION; LASER; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PH; TIME;

ACRYLONITRILE; ANIMALS; CARCINOGENS; CYSTEINE; ENZYME ACTIVATION; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; KINETICS; RABBITS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 0037102011     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(02)00046-7     Document Type: Article

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