Characterization of the cytotoxic mechanism of Mana-Hox, an analog of manzamine alkaloids

Biochimica et Biophysica Acta - General Subjects

Volumn 1672, Issue 3, 2004, Pages 148-156

  Tu, Lan Chun ^a,c   Chou, Chen Kung ^a   Chen, Ching Yeu ^b   Chang, Yao To ^b   Shen, Ya Ching ^b   Yeh, Sheau Farn ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Aberrant mitosis; Aik; Anticancer agent; aurora IPL1 related kinase; chromosome instability; Chromosome missegregation; CIN; Cytotoxicity; Mana Hox; Manzamine; microtubule organizing centers; MTOCs

Indexed keywords

ALKALOID DERIVATIVE; MANA HOX; MANZAMINE A; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL DEATH; CELL DIVISION; CELL LINE; CHROMOSOME; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE COURSE; DRUG ISOLATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; METAPHASE; MITOSIS; PRIORITY JOURNAL; TUMOR CELL;

ALKALOIDS; CARBAZOLES; CARBOLINES; CELL CYCLE; CELL LINE, TUMOR; CHROMOSOMES, HUMAN; CYTOTOXINS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MICROTUBULES; MITOTIC SPINDLE APPARATUS; NOCODAZOLE; PYRROLES;

EID: 2942534496     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2004.03.007     Document Type: Article

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