Physiological and metabolic actions of mycophenolate mofetil on cultured newborn rat cardiomyocytes in normoxia and in simulated ischemia

Fundamental and Clinical Pharmacology

Volumn 18, Issue 3, 2004, Pages 287-298

  Bès, Sandrine ^a   Tatou, Etienne ^a   Vandroux, David ^a   Tissier, Cindy ^a   Rochette, Luc ^a   Athias, Pierre ^a  

^a HÔPITAL DU BOCAGE   (France)

Author keywords

3 (4,5 dimethylthiazol 2 yl) 2,5 diphenyl tetrazolium bromide; Cell contractions; Electrophysiology; Ischemia reperfusion; Mycophenolate mofetil; Neonatal rat cardiomyocytes; Purine metabolites

Indexed keywords

HYPOXANTHINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; XANTHINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOMATION; CONTROLLED STUDY; CRYOPROTECTION; CYTOTOXICITY; DRUG EFFECT; ELECTRIC ACTIVITY; ELECTROCHEMISTRY; EVALUATION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE; ISCHEMIA; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; RAT; REOXYGENATION;

ADENOSINE; ANIMALS; ANIMALS, NEWBORN; CELL HYPOXIA; CELLS, CULTURED; HYPOXANTHINE; IMMUNOSUPPRESSIVE AGENTS; MEMBRANE POTENTIALS; MYCOPHENOLIC ACID; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCYTES, CARDIAC; RATS; RATS, WISTAR; XANTHINE;

EID: 2942522532     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2004.00237.x     Document Type: Article

References (30)

1. Mele T.S., Halloran P.F. The use of mycophenolate mofetil in transplant recipients. Immunopharmacology (2000) 47 215-245.
2. Allison A.C., Eugui E.M. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology (2000) 47 85-118.
3. Barten M.J., Van Gelder T., Gummert J.F. et al. Pharmacodynamics of mycophenolate mofetil after heart transplantation: new mechanisms of action and correlations with histologic severity of graft rejection. Am. J. Transplant. (2002) 2 719-732.
4. Weigel G., Griesmacher A., Karimi A., Zuckermann A.O., Grimm M., Mueller M.M. Effect of mycophenolate mofetil therapy on lymphocyte activation in heart transplant. J. Heart Lung Transplant. (2002) 21 1074-1079.
5. Lipsky J.J. Mycophenolate mofetil. Lancet (1996) 348 1357-1359.
6. Dambrin C., Klupp J., Morris R.E. Pharmacodynamics of immunosuppressive drugs. Curr. Opin. Immunol. (2000) 12 557-562.
7. Mathieu P., Carrier M., White M. et al. Effect of mycophenolate mofetil in heart transplantation. Can. J. Surg. (2000) 43 202-206.
8. Kobashigawa J., Miller L., Renlund D. et al. A randomized active-controlled trial of mycophenolate mofetil in heart transplant recipients. Mycophenolate Mofetil Investigators. Transplantation (1998) 66 507-515.
9. Valentin J.F., Bruijn J.A., Paul L.C. Donor treatment with mycophenolate mofetil - protection against ischemia-reperfusion injury in the rat. Transplantation (2000) 69 344-350.
10. Ostraat O., Qi Z., Olausson M., Tufveson G., Ekberg H. Mycophenolate mofetil, azathioprine and cyclophosphamide enhanced efficacy combined with cyclosporine in rat cardiac transplantation. Scand. J. Immunol. (1997) 45 343-348.
11. Olbrich H.G., Geerts H., Waldmann U. et al. The effect of cyclosporine on electrically paced isolated rat cardiomyocytes. Transplantation (1991) 51 972-976.
12. Athias P., Grynberg A. Electrophysiological studies on heart cells in culture, in: Pinson A. (Ed). The heart cells in culture, CRC Press, Boca Raton, USA, 1987, 1: pp. 125-158.
13. Pignier C., Ancey C., Fares N., Bescond J., Potreau D. Reexpression of the nifedipine-resistant calcium channel during dedifferentiation of adult rat ventricular cardiomyocytes. J. Cardiovasc. Electrophysiol. (2002) 13 178-183.
14. Grynberg A., Athias P., Degois M. Effect of changes in growth environment on cultured myocardial cells investigated in a standardized medium. In Vitro Cell. Dev. Biol. (1986) 22 44-50.
15. Ytrehus K. The ischemic heart - experimental models. Pharmacol. Res. (2000) 42 193-203.
16. Fantini E., Athias P., Courtois M., Khatami S., Grynberg A., Degois M. Oxygen and substrate deprivation on isolated rat cardiac myocytes: temporal relationship between electromechanical and biochemical consequences. Can. J. Physiol. Pharmacol. (1990) 68 1148-1156.
17. Tissier C., Bès S., Vandroux D., Fantini E., Rochette L., Athias P. Specific electromechanical responses of cardiomyocytes to individual and combined components of ischemia. Can. J. Physiol. Pharmacol. (2002) 80 1145-1157.
18. Fantini E., Athias P., Courtois M., Grynberg A. A simple gas-flow chamber for cultured cell electrophysiology in a controlled atmosphere. Pflügers Arch. Eur. J. Physiol. (1987) 409 632-634.
19. Chevalier A., Demaison L., Grynberg A., Athias P. Influence of the phospholipid polyunsaturated fatty acid composition on some metabolic disorders induced in rat cardiomyocytes by hypoxia and reoxygenation. J. Mol. Cell. Cardiol. (1990) 22 1177-1186.
20. Gomez L.A., Alekseev A.E., Aleksandrova L.A., Brady P.A., Terzic A. Use of the MTT assay in adult ventricular cardiomyocytes to assess viability: effects of adenosine and potassium on cellular survival. J. Mol. Cell. Cardiol. (1997) 29 1255-1266.
21. Silverman H.S., Stern M.D. Ionic basis of ischaemic cardiac injury: insights from cellular studies. Cardiovasc. Res. (1994) 28 581-597.
22. Gehrke C.W., Kuo K.C., Davis G.E., Suits R.D., Waalkes T.P., Borek E. Quantitative high-performance liquid chromatography of nucleosides in biological materials. J. Chromatogr. (1978) 150 455-476.
23. Dagnelie P. Théories et méthodes statistiques. Presses Agronomiques de Gembloux. Belgique, 1975.
24. Pally C., Tanner M., Rizvi H., Papageorgiou C., Schuurman H.-J. Tolerability profile of sodium mycophenolate (ERL080) and mycophenolate mofetil with and without cyclosporine (Neoral) in the rat. Toxicology (2001) 157 207-215.
25. Schuurman H.J., Fringeli-Tanner M., Pally C., Papageorgiou C. Mycophenolate sodium: tolerability and efficacy in transplantation in the rat. Transplant. Immunol. (2002) 9 187-195.
26. Renlund D.G., Gopinathan S.K., Kfoury A.G., Taylor D.O. Mycophenolate mofetil (MMF) in heart transplantation: rejection prevention and treatment. Clin. Transplant. (1996) 10 136-139.
27. Xia Y., Zweier J.L. Substrate control of free radical generation from xanthine oxidase in the postischemic heart. J. Biol. Chem. (1995) 270 18797-18803.
28. Courtois M., Maupoil V., Fantini E. et al. Correlation between direct ESR spectroscopic measurements and electromechanical and biochemical assessments of exogenous free radical injury in isolated rat cardiac myocytes. Free Rad. Biol. Med. (1997) 24 121-131.
29. Durot I., Maupoil V., Ponsard B., Cordelet C., Rochette L., Athias P. Oxidative injury of isolated cardiomyocytes: dependence on free radical species. Free Rad. Biol. Med. (2000) 29 846-857.
30. Laubriet A., Fantini E., Assem M. et al. Changes in HSP70 and in MnSOD transcripts levels during hypoxia-reoxygenation in cultured neonatal rat cardiomyocytes. Mol. Cell. Biochem. (2001) 220 77-86.