Mycophenolate mofetil (MMF) in heart transplantation: Rejection prevention and treatment

Clinical Transplantation

Volumn 10, Issue 1 II, 1996, Pages 136-139

  Renlund, Dale G ^a   Gopinathan, Santosh K ^b   Kfoury, Abdallah G ^b   Taylor, David O ^b  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^b NONE

Author keywords

Heart transplantation; Immunosuppression; Mycophenolate mofetil; Transplantation

Indexed keywords

AZATHIOPRINE; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

CLINICAL TRIAL; CONFERENCE PAPER; DRUG SAFETY; ERYTHROCYTE; GASTROINTESTINAL TOXICITY; GRAFT REJECTION; HEART TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LEUKOCYTE COUNT; LYMPHOCYTE; NEUTROPHIL; PRIORITY JOURNAL;

ANIMALS; AZATHIOPRINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTES; MULTICENTER STUDIES; MYCOPHENOLIC ACID; PLACEBOS; PROSPECTIVE STUDIES; PURINES; RANDOMIZED CONTROLLED TRIALS; SAFETY;

EID: 0029871188     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (29)

1. ENSLEY RD, BRISTOW MR, OLSEK SL, et al. The use of mycophenolate mofetil (RS-61443) in human heart transplant recipients. Transplantation 1993: 56: 75.
2. O'HAIR DP, MCMANUS RP, KOMOROWSKI R. Inhibition of chronic vascular rejection in primate cardiac xenografts using mycophenolate mofetil. Ann Thorac Surg 1994: 58: 1311.
3. YOUNG CJ, SOLLINGER HW. RS-61443: A new immunosuppressive agent. Transplant Proc 1994: 26: 3144.
4. MORRIS RE, HOYT EG, MURPHY MP, EUGUI EM, ALLISON AC. Mycophenolic acid morpholinoethylester (RS-61443) is a new immunosuppressant that prevents and halts heart allograft rejection by selective inhibition of T- and B-cell purine synthesis. Transplant Proc 1990: 22: 1659.
5. ALLISON AC, EUGUI EM. Preferential suppression of lymphocyte proliferation by mycophenolic acid and predicted long-term effects of mycophenolate mofetil in transplantation. Transplant Proc 1994: 26: 3205.
6. FIGUEROA J, FUAD SA, KUNJUMMEN BD, PLATT JL, BACH FH. Suppression of synthesis of natural antibodies by mycophenolate mofetil (RS-61443). Its potential use in discordant xenografting. Transplantation 1993: 55: 1371.
7. EUGUI EM, ALLISON AC. Immunosuppressive activity of mycophenolate mofetil. Ann NY Acad Sci 1993: 685: 309.
8. NAGY SE, ANDERSSON JP, ANDERSSON UG. Effect of mycophenolate mofetil (RS-61443) on cytokine production: Inhibition of superantigen-induced cytokines. Immunopharmacology 1993: 26: 11.
9. ALLISON AC, EUGUI EM. The design and development of an immunosuppressive drug, mycophenolate mofetil. Springer Semin Immunopathol 1993: 14: 353.
10. ALLISON AC, EUGUI EM. Mycophenolate mofetil (RS-61443): Mode of action and effects on graft rejection. In: THOMSON AW, STARZL TF, eds. Immunosuppressive Drugs: Developments in Anti-Rejection Therapy. New York: Edward Arnold, 1994: 141.
11. TAYLOR DO, ENSLEY RD, OLSEN SL, DUNN D, RENLUND DG. Mycophenolate mofetil (RS-61443): Preclinical, clinical, and three-year experience in heart transplantation. J Heart Lung Transplant 1994: 13: 571.
12. MORRIS RE, WANG J. Comparison of the immunosuppressive effects of mycophenolic acid and the morpholinoethyl ester of mycophenolic acid (RS-61443) in recipients of heart allografts. Transplant Proc 1991: 23: 493.
13. MORRIS RE, HOYT EG, EUGUI EM, ALLISON AC. Prolongation of rat heart allograft survival by RS 61443. Surg Forum 1989: 40: 337.
14. MORRIS RE, WANG J, BLUM JR, et al. Immunosuppressive efects of the morpholinoethyl ester of mycophenolic acid (RS-61443) in rat and nonhuman primate recipients of heart allografts. Transplant Proc 1991: 23: 19.
15. KAWAMURA T, HULLETT DA, SUZUKI Y, BECHSTEIN WO, ALLISON AM, SOLLINGER HW. Enhancement of allograft survival by combination RS-61443 and DUP-785 therapy. Transplantation 1993: 55: 691.
16. KNECHTLE SJ, WANG J, BURLINGHAM WJ, BEESKAU M, SUBRAMANIAN R, SOLLINGER HW. The influence of RS-61443 on antibody-mediated rejection. Transplantation 1992: 53: 699.
17. STEELE DM, HULLETT DA, BECHSTEIN WO, et al. Effects of immunosuppressive therapy on the rat aortic allograft model. Transplant Proc 1993: 25: 754.
18. WANG J, MORRIS RE. Effect of splenectomy and mono- or combination therapy with rapamycin. the morpholinoethyl ester of mycophenolic acid and deoxyspergualin on cardiac xenograft survival. Transplant Proc 1991: 23: 699.
19. MURASE N, STARZL TE, DEMETRIS AJ, VALDIVIA L. TANABE M, CRAMER D, MAKOWKA L. Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs. Transplantation 1993: 55: 701.
20. HULLETT DA, KAWAWURA T, FUJINO Y, ALLISON AM, SOLLINGER HW. Prolongation of allograft and xenograft survival with mycophenolate mofetil (RS-61443) and brequinar sodium (DUP-785). Transplant Proc 1993: 25: 700.
21. FUJINO Y, KAWAMURA T, HULLETT DA, SOLLINGER HW Evaluation of cyclosporine, mycophenolate mofetil, and brequinar sodium combination therapy on hamster-to-rat cardiac xenotransplantation. Transplantation 1994: 57: 41.
22. YATSCOFF RW, WANG S, KEENAN R, CHACKOWSKY P, KOSHAL A. Efficacy of rapamycin, RS-61443, and cyclophosphamide in the prolongation of survival of discordant pig-to-rabbit cardiac xenografts. Transplant Proc 1994: 26: 1271.
23. MCMANUS RP, O'HAIR DP, KOMOROWSKI R, SCOTT JP. Immunosuppressant combinations in primate cardiac xenografts. A review. Ann NY Acad Sci 1993: 696: 281.
24. KOBASHIGAWA JA, RENLUND DG, OLSEN SL, et al. Initial results of RS-61443 for refractory cardiac rejection. (Abstr) J Am Coll Cardiol 1992: 19: 203A.
25. KIRKLIN JK, DEIERHOI M, NAFTEL DC, et al. Treatment of recurrent cardiac rejection with RS-61443: Initial clinical experience. (Abstr) J Heart Lung Transplant 1992: 11: 223.
26. KIRKLIN JK, BOURGE RC, NAFTEL DC, et al. Treatment of recurrent heart rejection with mycophenolate mofetil (RS-61443): Initial clinical experience. J Heart Lung Transplant 1994: 13: 444.
27. DESRUENNES M, CABROL A, ABOUJAOUDE F, et al. Do we have to treat mild acute cardiac allograft rejection? (Abstr) J Heart Transplant 1990: 9: 64.
28. KOBASHIGAWA J, STEVENSON LW, MORIGUCHI J, et al. Randomized study of high dose oral cyclosporine therapy for mild acute cardiac rejection. J Heart Transplant 1989: 8: 53.
29. LAUFER G, LACZKOVICS A, WOLLENEK G, et al. The progression of mild acute cardiac rejection evaluated by risk factor analysis. Transplantation 1991: 51: 184.