Effect of mycophenolate mofetil therapy on lymphocyte activation in heart transplant recipients

Journal of Heart and Lung Transplantation

Volumn 21, Issue 10, 2002, Pages 1074-1079

  Weigel, Guenter ^a   Griesmacher, Andrea ^a,b   Karimi, Ali ^b   Zuckermann, Andreas O ^a   Grimm, Michael ^a   Mueller, Mathias M ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b KAISER FRANZ JOSEF HOSPITAL   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FEMALE; GRAFT REJECTION; HEART FAILURE; HEART TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE ACTIVATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADP-RIBOSYL CYCLASE; AGED; ANTIGENS, CD; ANTIGENS, CD38; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; B-LYMPHOCYTES; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; HEART TRANSPLANTATION; HLA-DR ANTIGENS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; IMP DEHYDROGENASE; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MYCOPHENOLIC ACID; POSTOPERATIVE PERIOD; RECEPTORS, INTERLEUKIN-2;

EID: 0036798990     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-2498(02)00440-0     Document Type: Article

References (20)

1. Immunosuppressive activity of mycophenolate mofetil
2. Preferential suppression of lymphocyte proliferation by mycophenolic acid and predicted long-term effects of mycophenolate mofetil in transplantation
3. Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF)
4. Pharmacodynamics of immunosuppression by mycophenolic acid; Inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics
5. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro; role of deoxyguanosine nucleotide depletion
6. Comparison of the in vitro and biophysical effects of cyclosporine A, FK-506, and mycophenolic acid on human peripheral blood lymphocytes
7. Effects of combined administration of FK 506 and the purine synthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures
8. The role of T-cell costimulatory activation pathways in transplant rejection
9. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation
10. T cell activation via Leu-23 (CD69)
11. Immune monitoring of blood in heart transplant recipients; application of flow cytometry
12. Immune monitoring in cardiac transplant recipients
13. In vitro immunosuppressive effects of mycophenolic acid and an ester prodrug, RS-61443
14. Inhibition of human B cell responses in vitro by RS-61443, cyclosporine A and FK506
15. In vitro effects of mycophenolic acid on cell cycle and activation of human lymphocytes
16. Regulatory functions of self-restricted MHC class II allopeptide Th2 clones in vivo
17. CD69 expression on peripheral CD4+ T cells parallels disease activity and is reduced by mycophenolate mofetil therapy in uveitis
18. Positive regulation of human T cell activation by Gi2 proteins and interleukin-8
19. Effect of mycophenolate mofetil therapy on inosine monophosphate dehydrogenase induction in red blood cells of heart transplant recipients
20. Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis