N-Acetyl cysteine regulates TNF-α-inhibited differentiation in ROS 17/2.8 osteoblasts

Immunopharmacology and Immunotoxicology

Volumn 26, Issue 2, 2004, Pages 203-213

  Chae, Han Jung ^a   Chae, Soo Wan ^a   Kim, Hyung Ryong ^b  

^a Chonbuk National University   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

Bone remodeling; N acetyl cysteine; Osteoblasts; TNF

Indexed keywords

ACETYLCYSTEINE; ALKALINE PHOSPHATASE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BONE REMODELING; CELL DIFFERENTIATION; ENZYME ACTIVITY; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN DNA BINDING; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ACETYLCYSTEINE; ALKALINE PHOSPHATASE; ANIMALS; CELL DIFFERENTIATION; CELL LINE; DRUG INTERACTIONS; ENZYME INHIBITORS; I-KAPPA B PROTEINS; NF-KAPPA B; OSTEOBLASTS; RATS; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 2942519187     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.1081/IPH-120037716     Document Type: Article

References (27)

1. Jilka, R.L.; Weinstein, R.S.; Bellido, T.; Parfitt, A.M.; Manolagas, S.C. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J. Bone Miner. Res. 1998, 13, 793-802.
2. Scharla, S.H.; Strong, D.D.; Mohan, S.; Chevalley, T.; Linkhart, T.A. Effect of tumor necrosis factor-alpha on the expression of insulin-like growth factor I and insulin-like growth factor binding protein 4 in mouse osteoblasts. Eur. J. Endocrinol. 1994, 131, 293-301.
3. DiDonato, J.A.; Hayakawa, M.; Rothwarf, D.M.; Zandi, E.; Karin, M. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappa B. Nature 1997, 388, 548-554.
4. Malinin, N.L.; Boldin, M.P.; Kovalenko, A.V.; Wallach, D. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 1997, 385, 540-544.
5. Haddad, J.J.; Land, S.C. Redox signaling-mediated regulation of lipopolysaccharide-induced proinflammatory cytokine biosynthesis in alveolar epithelial cells. Antioxid. Redox Signal. 2002, 4 (1), 179-193.
6. Iseki, A.; Kambe, F.; Okumura, K.; Niwata, S.; Yamamoto, R.; Hayakawa, T.; Seo, H. Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells. Biochem. Biophys. Res. Commun. 2000, 276 (1), 88-92.
7. Rangan, G.K.; Wang, Y.; Tay, Y.C.; Harris, D.C. Inhibition of NFkappaB activation with antioxidants is correlated with reduced cytokine transcription in PTC. Am. J. Physiol. 1999, 277 (5 pt. 2), F779-F789.
8. Chen, Y.M.; Tu, C.J.; Hung, K.Y.; Wu, K.D.; Tsai, T.J.; Hsieh, B.S. Inhibition by pentoxifylline of TNF-alpha-stimulated fractalkine production in vascular smooth muscle cells: evidence for mediation by NF-kappa B down-regulation. Br. J. Pharmacol. 2003, 138 (5), 950-958.
9. Tanaka, S.; Takehashi, M.; Matoh, N.; Iida S.; Suzuki, T.; Futaki, S.; Hamada, H.; Masliah, E.; Sugiura, Y.; Ueda, K. Generation of reactive oxygen species and activation of NF-kappaB by non-Abeta component of Alzheimer's disease amyloid. J. Neurochem. 2002, 82 (2), 305-315.
10. Rota, C.; Bergamini, S.; Daneri, F.; Tomasi, A.; Virgili, F.; Iannone, A. N-acetylcysteine negatively modulates nitric oxide production in endotoxin-treated rats through inhibition of NF-kappaB activation. Antioxid. Redox Signal. 2002, 4 (1), 221-226.
11. Gilston, V.; Williams, M.A.; Newland, A.C.; Winyard, P.G. Hydrogen peroxide and tumor necrosis factor-alpha induce NF-kappaB-DNA binding in primary human T lymphocytes in addition to T cell lines. Free Radic. Res. 2001, 35 (6), 681-691.
12. Hayashi, K.; Takahata, H.; Kitagawa, N.; Kitange, G.; Kaminogo, M.; Shibata, S. N-acetylcysteine inhibited nuclear factor-kappa B expression and the intimal hyperplasia in rat carotid arterial injury. Neurol. Res. 2001, 23 (7), 731-738.
13. Murley, J.S.; Kataoka, Y.; Hallahan, D.E.; Roberts, J.C.; Grdina, D.J. Activation of NF-kappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells. Free Radic. Biol. Med. 2001, 30 (12), 1426-1439.
14. Ali, N.N.; Gilston, V.; Winyard, P.G. Activation of NF-kappaB in human osteoblasts by stimulators of bone resorption. FEBS Lett. 1999, 460 (2), 315-320.
15. Chae, H.J.; Chae, S.W.; Kang, J.S.; Bang, B.G.; Cho, S.B.; Park, R.K.; So, H.S.; Kim, Y.K.; Kim, H.M.; Kim, H.R. Dexamethasone suppresses tumor necrosis factor-alpha-induced apoptosis in osteoblasts: possible role for ceramide. Endocrinology 2000, 141, 2904-2913.
16. Dignam, J.D.; Lebovitz, R.M.; Roeder, R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 1983, 11, 1475-1489.
17. Nathens, A.B.; Bitar, R.; Watson, R.W.; Issekutz, T.B.; Marshall, J.C.; Dackiw, A.P.; Rotstein, O.D. Thiol-mediated regulation of ICAM-1 expression in endotoxin-induced acute lung injury. J. Immunol. 1998, 160 (6), 2959-2966.
18. Ercal, N.; Treeratphan, P.; Hammond, T.C.; Matthews, R.H.; Grannemann, N.H.; Spitz, D.R. In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine. Free Radic. Biol. Med. 1996, 21 (2), 157-161.
19. Mayer, B.; Schrammel, A.; Klatt, P.; Koesling, D.; Schmidt, K. Peroxynitrite-induced accumulation of cyclic GMP in endothelial cells and stimulation of purified soluble guanylyl cyclase. Dependence on glutathione and possible role of S-nitrosation. J. Biol. Chem. 1995, 270 (29), 17355-17360.
20. Goin, J.; Giulivi, C.; Butler, J.; Cadenas, E. Enzymic- and thiol-mediated activation of halogen-substituted diaziridinylbenzoquinones: redox transitions of the semiquinone and semiquinone-thioether species. Free Radic. Biol. Med. 1995, 18 (3), 525-536.
21. Rahman, I.; Gilmour, P.S.; Jimenez, L.A.; MacNee, W. Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. Mol. Cell. Biochem. 2002, 234-235(1-2), 239-248.
22. Kamata, H.; Manabe, T.; Oka, S.; Kamata, K.; Hirata, H. Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops. FEBS Lett. 2002, 519 (1-3), 231-237.
23. 2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester. J. Immunol. 2002, 168 (6), 2644-2651.
24. Zhang, J.; Johnston, G.; Stebler, B.; Keller, E.T. Hydrogen peroxide activates NFkappaB and the interleukin-6 promoter through NFkappaB-inducing kinase. Antioxid. Redox Signal. 2001, 3 (3), 493-504.
25. Ginis, I.; Hallenbeck, J.M.; Liu, J.; Spatz, M.; Jaiswal, R.; Shohami, E. Tumor necrosis factor and reactive oxygen species cooperative cytotoxicity is mediated via inhibition of NF-kappaB. Mol. Med. 2000, 6 (12), 1028-1041.
26. Jaspers, I.; Zhang, W.; Fraser, A.; Samet, J.M.; Reed, W. Hydrogen peroxide has opposing effects on IKK activity and IkappaBalpha breakdown in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 2001, 24 (6), 769-777.
27. Zhou, H.; Choong, P.; McCarthy, R.; Chou, S.T.; Martin, T.J.; Ng, K.W. In situ hybridization to show sequential expression of osteoblast gene markers during bonex formation in vivo. J. Bone Miner. Res. 1994, 9 (9), 1489-1499.