Internalization of constitutive desmogleins with the subsequent induction of desmoglein 2 in pemphigus lesions

British Journal of Dermatology

Volumn 140, Issue 1, 1999, Pages 35-43

  Iwatsuki, Keiji ^a   Han, G W ^a   Fukuti, R ^a   Ohtsuka, M ^a   Kikuchi, S ^a   Akiba, H ^a   Kaneko, F ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Constitutive desmogleins; Desmoglein expression; Histogenesis of acantholysis; Keratinocytes; Pemphigus foliaceus; Pemphigus vulgaris

Indexed keywords

DESMOGLEIN; UVOMORULIN;

ACANTHOLYSIS; ANTIGEN EXPRESSION; ARTICLE; BLISTER; CLINICAL ARTICLE; CONTROLLED STUDY; DESMOSOME; EPIDERMIS; HISTOGENESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERNALIZATION; KERATINOCYTE; PEMPHIGUS FOLIACEUS; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; PROTEIN INDUCTION;

CELLS, CULTURED; CYTOPLASM; CYTOSKELETAL PROTEINS; DESMOGLEIN 2; DESMOGLEINS; DESMOPLAKINS; DESMOSOMES; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; KERATINOCYTES; MICROSCOPY, IMMUNOELECTRON; PEMPHIGUS;

EID: 0032973001     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1999.02604.x     Document Type: Article

References (25)

1. Stanley JR, Koulu L, Thivolet C. Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus filiaceus autoantibodies. J Clin Invest 1984; 74: 313-20.
2. Amagai M, Klaus-Kovtun V, Stanley JR. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 1991; 67: 869-77.
3. Amagai M. Adhesion molecules I: Keratinocyte-keratinocyte interactions; cadherins and pemphigus. J Invest Dermatol 1995; 104: 146-52.
4. Hashimoto K, Shafran EM, Webber PS et al. Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells. J Exp Med 1983; 157: 259-72.
5. Morioka S, Lazarus GS, Jansen PJ. Involvement of urokinase-type plasminogen activator in acantholysis induced by pemphigus IgG. J Invest Dermatol 1987; 89: 474-7.
6. Seishima M, Esaki C, Osada K et al. Pemphigus IgG, but not bulluos pemphigoid IgG, causes a transient increase in intracellular calcium and inositol 1,4, 5-triphosphate in DLM-1 cells, squamous cell carcinoma line. J Invest Dermatol 1995; 104: 33-7.
7. Iwatsuki K, Takigawa M, Imaizumi S, Yamada M. In vivo binding site of pemphigus vulgaris antibodies and their fate during acantholysis. J Am Acad Dermatol 1989; 20: 578-82.
8. Carlotti A, Balaton AJ, de Muret A et al. Autoimmune pemphigus. A distinct staining pattern with an anti-desmoglein antibody. Arch Dermatol 1993; 129: 596-9.
9. Burge SM, Wilson CL, Dean D, Wojnarowska F. An immunohistological study of desmosomal components in pemphigus. Br J Dermatol 1993; 128: 363-70.
10. Buxton RS, Cowin P, Franke WW et al. Nomenclature of the desmosomal cadherins. J Cell Biol 1993; 121: 481-3.
11. Chidgey MAJ. Desmosomes and disease. Histol Histopathol 1997; 12: 1159-68.
12. Simrak D, Cowley CME, Buxton RS, Arnemann J. Tandem arrangement of the closely linked desmoglein genes on human chromosome 18. Genomics 1995; 25: 591-4.
13. Arnemann J, Sullivan KH, Magee AJ et al. Stratification related expression of isoforms of the desmosomal cadherins in human epidermis. J Cell Sci 1993; 104: 741-50.
14. Iwatsuki K, Harada H, Yokote R, Kaneko F. Differences in the expression of pemphigus antigens during epidermal differentiation. Br J Dermatol 1995; 133: 209-16.
15. Amagai M, Koch PJ, Nishikawa T, Stanley JR. Pemphigus valgaris antigen (desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients. J Invest Dermatol 1996; 106: 531-5.
16. Shimizu H, Masunaga T, Ishiko A et al. Pemphigus vulgaris and pemphigus follaceus sera show an inversely graded pattern to extracellular regions of desmosomes in different layers of human epidermis. J Invest Dermatol 1995; 105: 153-9.
17. Schafer S, Stumpp S, Franke WW. Immunological identification and characterization of the desmosomal cadherin Dsg2 in coupled and uncoupled epithelial cells and in human tissues. Differentiation 1996; 60: 99-108.
18. Harada H, Iwatsuki K, Kaneko F. Abnormal desmoglein expression by squamous cell carcinoma cells. Acta Derm Venereol (Stockh) 1996; 76: 417-20.
19. Denning MF, Guy SG, Ellerbroek SM et al. The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C. Exp Cell Res 1998; 239: 50-9.
20. Setoyama M, Choi KC, Hashimoto K et al. Desmoplakin I and II in acantholytic dermatoses: Preservation in pemphigus vulgaris and pemphigus erythematosus and dissolution in Hailey-Hailey's disease and Darier's disease. J Dermatol Sci 1991; 2: 9-17.
21. Hashimoto K, Fujiwara K, Tada J et al. Desmosomal dissolution in Grover's disease, Hailey-Hailey's disease and Darier's disease. J Cutan Pathol 1995; 22: 488-501.
22. Tada J, Hashimoto K. Ultrastructural localization of cell junctional components (desmoglein, plakoglobin, E-cadherin, and β-catenin) inl Hailey-Hailey disease, Darier's disease, and pemphigus vulgaris. J Cutan Pathol 1998; 25: 106-15.
23. Tada J, Hashimoto K. Curvicircular intracytoplasmic membranous structures in keratinocytes of pemphigus foliaceus. J Cutan Pathol 1996; 25: 511-17.
24. Kitajima Y, Nojiri M, Yamada T et al. Internalization of the 180 kDa bullous pemphigoid antigen as immune complexes in basal keratinocytes: An important early event in blister formation in bullous pemphigoid. Br J Dermatol 1998; 138: 71-6.
25. Osada K, Seishima M, Kitajima Y, Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes. J Invest Dermatol 1997; 108: 482-7.