Role of mitochondrial membrane permeability transition in N-nitrosofenfluramine-induced cell injury in rat hepatocytes

European Journal of Pharmacology

Volumn 529, Issue 1-3, 2006, Pages 33-39

  Nakagawa, Yoshio ^a   Suzuki, Toshinari ^a   Kamimura, Hisashi ^a   Nagai, Fumiko ^a  

^a TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

Appetite suppressant; Dietary supplement; Fenfluramine; Hepatonecrosis; Mitochondrial dysfunction; Mitochondrial permeability transition; N nitrosofenfluramine

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM ION; CYCLOSPORIN A; CYTOCHROME C; FENFLURAMINE; N NITROSOFENFLURAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CELL ISOLATION; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; LIVER CELL DAMAGE; MALE; MITOCHONDRIAL MEMBRANE; NONHUMAN; ONSET AGE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; CELL DEATH; CELLS, CULTURED; CYCLOSPORINE; CYTOCHROMES C; DIETARY SUPPLEMENTS; FENFLURAMINE; HEPATOCYTES; ION CHANNELS; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL SWELLING; RATS; RATS, INBRED F344;

EID: 29344466462     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.10.042     Document Type: Article

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