N-Nitrosofenfluramine induces cytotoxicity via mitochondrial dysfunction and oxidative stress in isolated rat hepatocytes

Archives of Toxicology

Volumn 79, Issue 6, 2005, Pages 312-320

  Nakagawa, Yoshio ^a   Suzuki, Toshinari ^a   Kamimura, Hisashi ^a   Nagai, Fumiko ^a  

^a TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

Appetite suppressant; Dietary supplements; Fenfluramine; Hepatotoxicity; Mitochondrial dysfunction; N Nitrosofenfluramine; Rat hepatocytes

Indexed keywords

ACETYLCYSTEINE; ADENINE NUCLEOTIDE; ADENOSINE TRIPHOSPHATE; FENFLURAMINE; GLUTATHIONE; MALONALDEHYDE; N NITROSOFENFLURAMINE; OXYGEN; RHODAMINE 123; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL ORGANELLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; LIPID PEROXIDATION; LIVER CELL; LIVER INJURY; LIVER MITOCHONDRION; MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

ADENINE NUCLEOTIDES; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FENFLURAMINE; GLUTATHIONE; HEPATOCYTES; MALE; MALONDIALDEHYDE; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; RATS; RATS, INBRED F344; SULFHYDRYL COMPOUNDS; TIME FACTORS;

EID: 20544458340     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-004-0635-3     Document Type: Article

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