Effect of wheat gluten hydrolysate on the immune system in healthy human subjects

Bioscience, Biotechnology and Biochemistry

Volumn 69, Issue 12, 2005, Pages 2445-2449

  Horiguchi, Noboru ^a   Horiguchi, Hiroshi ^a   Suzuki, Yoshio ^b  

^a Horiguchi Clinic   (Japan)

^b NISSHIN SEIFUN GROUP INC   (Japan)

Author keywords

Immune system; Natural killer cell activity; NK; Wheat gluten hydrolysate

Indexed keywords

BIOCHEMISTRY; BIOTECHNOLOGY; CELLS; CYTOLOGY; ENZYMES; HORMONES;

CELL ACTIVITY; HEMATOLOGICAL PARAMETERS; IMMUNE SYSTEMS; WHEAT GLUTEN HYDROLYSATE;

IMMUNOLOGY;

CHROMIUM; DIAGNOSTIC AGENT; GLUTEN; IMMUNOLOGICAL ADJUVANT; PROTEIN HYDROLYSATE;

ADULT; ARTICLE; BLOOD CELL COUNT; CELL STRAIN K 562; CELLULAR IMMUNITY; CHEMISTRY; CLINICAL TRIAL; DRUG EFFECT; FEMALE; HUMAN; IMMUNOLOGY; LEUKOCYTE COUNT; MALE; MIDDLE AGED; NATURAL KILLER CELL; WHEAT;

ADJUVANTS, IMMUNOLOGIC; ADULT; BLOOD CELL COUNT; CHROMIUM RADIOISOTOPES; FEMALE; GLUTEN; HUMANS; IMMUNITY, CELLULAR; K562 CELLS; KILLER CELLS, NATURAL; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PROTEIN HYDROLYSATES; TRITICUM;

TRITICUM AESTIVUM;

EID: 29344463656     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.69.2445     Document Type: Article

References (43)

1. Kasarda, D., Okita, T., Bernardin, J., Baecker, P., Nimmo, C., Lew, E., Dietler, M., and Greene, F., Nucleic acid (cDNA) and amino acid sequences of alpha-type gliadins from wheat (Triticum aestivum). Proc. Natl. Acad. Sci. U.S.A., 81, 4712-4716 (1984).
2. Furukawa, S., Saito, H., Inaba, T., Lin, M. T., Inoue, T., Naka, S., Fukatsu, K., Hashiguchi, Y., Han, I., Matsuda, T., Ikeda, S., and Muto, T., Glutamine-enriched enterai diet enhances bacterial clearance in protected bacterial peritonitis, regardless of glutamine form. JPEN J. Parenter. Enterai. Nutr., 21, 208-214 (1997).
3. Sawaki, K., Takaoka, I., Sakuraba, K., and Suzuki, Y., Effects of distance running and subsequent intake of glutamine rich peptide on biomedical parameters of male Japanese athletes. Nutr. Res., 24, 59-71 (2004).
4. Young, V. R., and Ajami, A. M., Glutamine: the emperor or his clothes? J. Nutr., 131, 2449S-2459S (2001).
5. 3H]thymidine into DNA in rat mesenteric lymphocytes stimulated by phytohaemagglutinin. Biochem. J., 261, 979-983 (1989).
6. Wischmeyer, P. E., Riehm, J., Singleton, K. D., Ren, H., Musch, M. W., Kahana, M., and Chang, E. B., Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. Nutrition, 19, 1-6 (2003).
7. Boelens, P. G., Houdijk, A. P., Fonk, J. C., Nijveldt, R. J., Ferwerda, C. C., Von Blomberg-Van Der Flier, B. M., Thijs, L. G., Haarman, H. J., Puyana, J. C., and Van Leeuwen, P. A., Glutamine-enriched enterai nutrition increases HLA-DR expression on monocytes of trauma patients. J. Nutr., 132, 2580-2586 (2002).
8. Moinard, C., Caldefie-Chezet, F., Walrand, S., Vasson, M. P., and Cynober, L., Evidence that glutamine modulates respiratory burst in stressed rat polymorphonuclear cells through its metabolism into arginine. Br. J. Nutr., 88, 689-695 (2002).
9. Novak, F., Heyland, D. K., Avenell, A., Drover, J. W., and Su, X., Glutamine supplementation in serious illness: a systematic review of the evidence. Crit. Care Med., 30, 2022-2029 (2002).
10. Schusdziarra, V., Henrichs, I., Holland, A., Klier, M., and Pfeiffer, E. F., Evidence for an effect of exorphins on plasma insulin and glucagons levels in dogs. Diabetes, 30, 362-364 (1981).
11. Schusdziarra, V., Schick, R., Holland, A., de la Fuente, A., Specht, J., Maier, V., Brantl, V., and Pfeiffer, E. F., Effect of opiate-active substances on pancreatic polypeptide levels in dogs. Peptides, 4, 205-210 (1983).
12. Morley, J. E., Levine, A. S., Yamada, T., Gebhard, R. L., Prigge, W. F., Shafer, R. B., Goetz, F. C., and Silvis, S. E., Effect of exorphins on gastrointestinal function, hormonal release, and appetite. Gastroenterol., 84, 1517-1523 (1983).
13. Fukudome, S., and Yoshikawa, M., Opioid peptides derived from wheat gluten: their isolation and characterization. FEBS Lett., 296, 107-111 (1992).
14. Fukudome, S., and Yoshikawa, M., Gluten exorphin C: a novel opioid peptide derived from wheat gluten. FEBS Lett., 316, 17-19 (1993).
15. Motoi, H., and Kodama, T., Isolation and characterization of angiotensin I-converting enzyme inhibitory peptides from wheat gliadin hydrolysate. Nahrung, 47, 354-358 (2003).
16. Horiguchi, N., Horiguchi, H., and Suzuki, Y., Out-hospital patients with hyperlipidemia and hepatitis with various backgrounds improved by wheat protein hydrolysate (glutamine peptide) administration. Jpn. Pharmacol. Ther., 32, 415-420 (2004).
17. Pedersen, B. K., and Kharazmi, A., Inhibition of human natural killer cell activity by Pseudomonas aeruginosa alkaline protease and elastase. Infect. Immun., 55, 986-989 (1987).
18. Herberman, R. B., and Oltaldo, J. R., Natural killer cells: their roles in defences against disease. Science, 214, 24-30 (1981).
19. Talmadge, J. E., Meyers, K. M., Prieur, D. J., and Starkey, J. R., Role of NK cells in tumor growth and metastasis in beige mice. Nature, 248, 622-624 (1980).
20. Nagao, F., Yabe, T., Xu, M., and Okumura, K., Phenotypical and functional analyses of natural killer cells from low NK activity individuals among healthy and patient populations. Nat. Immun., 14, 225-233 (1995).
21. Tada, T., and Okumura, K., Senescence and immunity. Chemistry Today (in Japanese), 11, 40-45 (1984).
22. Yokota, T., Uehara, K., and Nomoto, Y., Addition of noradrenaline to intrathecal morphine augments the postoperative suppression of natural killer cell activity. J. Anesth., 18, 190-195 (2004).
23. Hillyard, D. Z., Cameron, A. J., McDonald, K. J., Thomson, J., MacIntyre, A., Shiels, P. G., Panarelli, M., and Jardine, A. G., Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease. Atherosclerosis, 175, 305-313 (2004).
24. Yamazaki, T., Sugiyama, K., and Ichihara, K., Effect of ubenimex on the immune system of patients with hematological malignancies. Biomed. Pharmacother., 45, 105-112 (1991).
25. Kano, Y., Kakuta, H., and Hashimoto, J., Effect of sizofiran on regional lymph nodes in patients with head/neck cancer. Biotherapy (in Japanese), 9, 257-262 (1996).
26. Aizen, E., Kagan, G., Assy, B., Iobel, R., Bershadsky, Y., and Gilhar, A., Effect of non-steroidal anti-inflammatory drugs on natural killer cell activity in patients with dementia. Isr. Med. Assoc. J., 7, 78-81 (2005).
27. Bobek, V., Boubelik, M., Fišerová, A., L'uptovcová, M., Vannucci, L., Kacprzak, G., Kolodzej, J., Majewski, A. M., and Hoffman, R. M., Anticoagulant drugs increase natural killer cell activity in lung cancer. Lung Cancer, 47, 215-223 (2005).
28. Kuroiwa, A., Liou, S., Yan, H., Eshita, A., Naitoh, S., and Nagayama, A., Effect of a traditional Japanese herbal medicine, hochu-ekki-to (Bu-Zhong-Yi-Qi Tang), on immunity in elderly persons. Int. Immunopharmacol., 4, 317-324 (2004).
29. Krzywkowski, K., Petersen, E. W., Ostrowski, K., Kristensen, J. H., Boza, J., and Pedersen, B. K., Effect of glutamine supplementation on exercise-induced changes in lymphocyte function. Am. J. Physiol. Cell Physiol., 281, C1259-1265 (2001).
30. Watzl, B., Bub, A., Briviba, K., and Rechkemmer, G., Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men. Ann. Nutr. Metab., 47, 255-261 (2003).
31. Albers, R., van der Wielen, R. P., Brink, E. J., Hendriks, H. F., Dorovska-Taran, V. N., and Mohede, I. C., Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. Eur. J. Clin. Nutr., 51, 595-603 (2003).
32. Pongnikorn, S., Fongmoon, D., Kasinrerk, W., and Limtrakul, P. N., Effect of bitter melon (Momordica charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy. J. Med. Assoc. Thai., 86, 61-68 (2003).
33. Nagao, F., Nakayama, M., Muto, T., and Okumura, K., Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects. Biosci. Biotechnol. Biochem., 64, 2706-2708 (2000).
34. Parra, M. D., Martinez de Morentin, B. E., Cobo, J. M., Mateos, A., and Martínez, J. A., Daily ingestion of fermented milk containing Lactobacillus casei DN114001 improves innate-defense capacity in healthy middle-aged people. J. Physiol. Biochem., 60, 85-91 (2004).
35. Gill, H. S., Rutherfurd, K. J., and Cross, M. L., Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. J. Clin. Immunol., 21, 264-271 (2001).
36. Gao, Y., Zhou, S., Jiang, W., Huang, M., and Dai, X., Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol. Invest., 32, 201-215 (2003).
37. Hasegawa, A., Yamada, M., Dombo, M., Fukushima, R., Matsuura, N., and Sugitachi, A., Sparassis crispa as biological response modifier. Jpn. J. Cancer Chemother. (in Japanese), 31, 1761-1763 (2004).
38. Klinke, H. B., Ahring, B. K., Schmidt, A. S., and Thomsen, A. B., Characterization of degradation products from alkaline wet oxidation of wheat straw. Bioresource Technol., 82, 15-26 (2002).
39. Beaugrand, J., Crônier, D., Thiebeau, P., Schreiber, L., Debeire, P., and Chabbert, B., Structure, chemical composition, and xylanase degradation of external layers isolated from developing wheat grain. J. Agric. Food Chem., 52, 7108-7117 (2004).
40. Nagata, J., Higashiuesato, Y., Maeda, G., Chinen, I., Saito, M., Iwabuchi, K., and Onoē, K., Effects of water-soluble hemicellulose from soybean hull on serum antibody levels and activation of macrophages in rats. J. Agric. Food Chem., 49, 4965-4970 (2001).
41. Ghoneum, M., and Abedi, S., Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). J. Pharm. Pharmacol., 56, 1581-1588 (2004).
42. Prosky, L., Nils-Georg, A. S. P., Furda, I., Devries, J. W., Schweizer, T. F., and Harland, B. F., Determination of total dietary fiber in foods, food products, and total diets, an interlaboratory study. J. Assoc. Off. Anal. Chem., 67, 1044-1052 (1984).
43. Nishimune, T., Sumimoto, T., Yakusiji, T., Kunita, N., Ichikawa, T., Doguchi, M., and Nakahara, S., Determination of total dietary fiber in Japanese foods. J. Assoc. Off. Anal. Chem., 74, 350-359 (1991).