Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell

Tumor Biology

Volumn 27, Issue 1, 2006, Pages 17-26

  Bausero, Maria A ^a,c   Bharti, Ajit ^a   Page, Diana T ^a   Perez, Kristen D ^a,b   Eng, Jason W L ^a   Ordonez, Susana L ^a   Asea, Edwina E ^a,b   Jantschitsch, Christian ^d   Kindas Muegge, Ingela ^e   Ciocca, Daniel ^f   Asea, Alexzander ^a,b,g  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b TEXAS A M COLLEGE OF MEDICINE   (United States)

^c UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^d UNIVERSITY OF VIENNA   (Austria)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^g TEXAS A AND M UNIVERSITY SYSTEM   (United States)

Author keywords

Breast carcinoma; Chaperokine; Heat shock proteins; Metastasis; siRNA

Indexed keywords

GELATINASE B; HEAT SHOCK PROTEIN 25; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANIMAL CELL; ARTICLE; BREAST ADENOCARCINOMA; BREAST METASTASIS; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME REPRESSION; GENE SILENCING; GENETIC TRANSFECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA INTERFERENCE; TUMOR GROWTH; UPREGULATION;

EID: 29244474560     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000090152     Document Type: Article

References (34)

1. Weir HK, Thun MJ, Hankey BF, Ries LA, Howe HL, Wingo PA, Jemal A, Ward E, Anderson RN, Edwards BK: Annual report to the nation on the status of cancer, 1975-2000, featuring the uses of surveillance data for cancer prevention and control. J Natl Cancer Inst 2003;95:1276-1299.
2. Kim J, Yu W, Kovalski K, Ossowski L: Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. Cell 1998;94:353-362.
3. Egeblad M, Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002;2:161-174.
4. Neumark E, Sagi-Assif O, Shalmon B, Ben-Baruch A, Witz IP: Progression of mouse mammary tumors: MCP-1-TNFalpha cross-regulatory pathway and clonal expression of promalignancy and antimalignancy factors. Int J Cancer 2003;106:879-886.
5. Lirdprapamongkol K, Sakurai H, Kawasaki N, Choo MK, Saitoh Y, Aozuka Y, Singhirunnusorn P, Ruchirawat S, Svasti J, Saiki I: Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. Eur J Pharm Sci 2005;25:57-65.
6. Soldes OS, Kuick RD, Thompson IA 2nd, Hughes SJ, Orringer MB, Iannettoni MD, Hanash SM, Beer DG: Differential expression of Hsp27 in normal oesophagus, Barrett's metaplasia and oesophageal adenocarcinomas. Br J Cancer 1999;79:595-603.
7. Jantschitsch C, Trautinger F: Heat shock and UV-B-induced DNA damage and mutagenesis in skin. Photochem Photobiol Sci 2003;2:899-903.
8. Wieder R: Insurgent micrometastases: sleeper cells and harboring the enemy. J Surg Oncol 2005;89:207-210.
9. Oesterreich S, Hilsenbeck SG, Ciocca DR, Allred DC, Clark GM, Chamness GC, Osborne CK, Fuqua SA: The small heat shock protein HSP27 is not an independent prognostic marker in axillary lymph node-negative breast cancer patients. Clin Cancer Res 1996;2:1199-1206.
10. Ciocca DR, Vargas-Roig LM: Hsp27 as a prognostic and predictive factor in cancer. Prog Mol Subcell Biol 2002;28:205-218.
11. Ciocca DR, Green S, Elledge RM, Clark GM, Pugh R, Ravdin P, Lew D, Martino S, Osborne CK: Heat shock proteins hsp27 and hsp70: lack of correlation with response to tamoxifen and clinical course of disease in estrogen receptor-positive metastatic breast cancer (a Southwest Oncology Group Study). Clin Cancer Res 1998;4:1263-1266.
12. Ciocca DR, Rozados VR, Cuello Carrion FD, Gervasoni SI, Matar P, Scharovsky OG: Hsp25 and Hsp70 in rodent tumors treated with doxorubicin and lovastatin. Cell Stress Chaperones 2003;8:26-36.
13. Cornford PA, Dodson AR, Parsons KF, Desmond AD, Woolfenden A, Fordham M, Neoptolemos JP, Ke Y, Foster CS: Heat shock protein expression independently predicts clinical outcome in prostate cancer. Cancer Res 2000;60:7099-7105.
14. Bausero MA, Page DT, Osinaga E, Asea A: Surface expression of Hsp25 and Hsp72 differentially regulates tumor growth and metastasis. Tumor Biol 2004;25:243-251.
15. Asea A: Exogenous Hsp70: principles and application of the chaperokine activity of Hsp70; in Henderson B, Pockley AG (eds): The Extracellular Biology of Molecular Chaperones. London, Cambridge University Press, 2005.
16. Asea A, Ara G, Teicher BA, Stevenson MA, Calderwood SK: Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo. Int J Hyperthermia 2001;17:347-356.
17. Jaattela M, Wissing D, Kokholm K, Kallunki T, Egeblad M: Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J 1998;17:6124-6134.
18. Calderwood SK, Asea A: Targeting HSP70-induced thermotolerance for design of thermal sensitizers. Int J Hyperthermia 2002;18:597-608.
19. Jaattela M: Programmed cell death: many ways for cells to die decently. Ann Med 2002;34:480-488.
20. Farkas B, Hantschel M, Magyarlaki M, Becker B, Scherer K, Landthaler M, Poster K, Gehrmann M, Gross C, Mackensen A, Multhoff G: Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma. Melanoma Res 2003;13:147-152.
21. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, Calderwood SK: Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 2002;277:15028-15034.
22. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, Calderwood SK: HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 2000;6:435-442.
23. Asea A, Kabingu E, Stevenson MA, Calderwood SK: HSP70 peptide-bearing and peptide-negative preparations function as chaperokines. Cell Stress Chaperones 2000;5:425-431.
24. Basu S, Suto R, Binder RJ, Srivastava PK: Heat shock proteins as novel mediators of cytokine secretion by macrophages. Cell Stress Chaperones 1998;3:11-16.
25. Blackburn RV, Galoforo SS, Berns CM, Armour EP, McEachern D, Corry PM, Lee YJ: Comparison of tumor growth between hsp25-and hsp27-transfected murine L929 cells in nude mice. Int J Cancer 1997;72:871-877.
26. Lemieux P, Oesterreich S, Lawrence JA, Steeg PS, Hilsenbeck SG, Harvey JM, Fuqua SA: The small heat shock protein hsp27 increases invasiveness but decreases motility of breast cancer cells. Invasion Metastasis 1997;17:113-123.
27. Eskenazi AE, Powers J, Pinkas J, Oesterreich S, Fuqua SA, Frantz CN: Induction of heat shock protein 27 by hydroxyurea and its relationship to experimental metastasis. Clin Exp Metastasis 1998;16:283-290.
28. Aldrian S, Trautinger F, Frohlich I, Berger W, Micksche M, Kindas-Mugge I: Overexpression of Hsp27 affects the metastatic phenotype of human melanoma cells in vitro. Cell Stress Chaperones 2002;7:177-185.
29. Park SH, Lee YS, Osawa Y, Hachiya M, Akashi M: Hsp25 regulates the expression of p21 (Waf1/Cip1/Sdi1) through multiple mechanisms. J Biochem (Tokyo) 2002;131:869-875.
30. Lee YJ, Cho HN, Jeoung DI, Soh JW, Cho CK, Bae S, Chung HY, Lee SJ, Lee YS: HSP25 overexpression attenuates oxidative stress-induced apoptosis: roles of ERK1/2 signaling and manganese superoxide dismutase. Free Radic Biol Med 2004;36:429-444.
31. Smith MC, Luker KE, Garbow JR, Prior JL, Jackson E, Piwnica-Worms D, Luker GD: CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 2004;64:8604-8612.
32. Liang Z, Yoon Y, Votaw J, Goodman MM, Williams L, Shim H: Silencing of CXCR4 blocks breast cancer metastasis. Cancer Res 2005;65:967-971.
33. Wang T, Yamashita K, Iwata K, Hayakawa T: Both tissue inhibitors of metalloproteinases-1 (TIMP-1) and TIMP-2 activate Ras but through different pathways. Biochem Biophys Res Commun 2002;296:201-205.
34. Tanimura S, Asato K, Fujishiro SH, Kohno M: Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44. Biochem Biophys Res Commun 2003;304:801-806.