Analysis and sequencing of the active-site peptide from native and organophosphate-inactivated acetylcholinesterase by electrospray ionization, quadrupole/time-of-flight (QTOF) mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 830, Issue 1, 2006, Pages 105-113

  Spaulding, Reggie S ^a   George, Kathleen M ^a   Thompson, Charles M ^a  

^a UNIVERSITY OF MONTANA   (United States)

Author keywords

Acetylcholinesterase; Active site; Chymotrypsin; Ethyl paraoxon; Methyl paraoxon; MS; Organophosphate; Peptide; QTOF

Indexed keywords

ENZYMES; IONIZATION; MASS SPECTROMETRY; PHOSPHATES;

ACETYLCHOLINESTERASE; ACTIVE SITE; CHYMOTRYPSIN; ETHYL PARAOXON; METHYL PARAOXON; ORGANOPHOSPHATE; PEPTIDE; QTOF;

LIQUID CHROMATOGRAPHY;

2 PROPANOL; ACETYLCHOLINESTERASE; CHYMOTRYPSIN; ETHYL PARAOXON; GLYCYLGLUTAMYLSERYLALANYLGLYCYLALANYLALANYLSERYLVALYLGLYCYLMETHIONYL HISTIDYLISOLEUCYLLEUCINE; METHYLPARAOXON; ORGANOPHOSPHATE; PARAOXON; PEPTIDE DERIVATIVE; PHOSPHORIC ACID DERIVATIVE; THREONYLLEUCYLPHENYLALANYLGLYCYLGLUTAMYLSERYLALANYLGLYCYLALANYLALANINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME MODIFICATION; LIQUID CHROMATOGRAPHY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY;

ACETYLCHOLINESTERASE; AMINO ACID SEQUENCE; BINDING SITES; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, LIQUID; HYDROLYSIS; MOLECULAR SEQUENCE DATA; PEPTIDES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 29244450502     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.10.023     Document Type: Article

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