Cancer gene discovery using the sleeping beauty transposon

Cell Cycle

Volumn 4, Issue 12, 2005, Pages 1744-1748

  Starr, Timothy K ^a   Largaespada, David A ^a,b  

^a Minnesota Medical School Minneapolis   (United States)

^b 6 160 Jackson Hall ^*  (United States)

Author keywords

Cancer; Cancer genetics; Mutagenesis screen; Oncogenesis; Sleeping Beauty; Transposon

Indexed keywords

ACCELERATION; CANCER GENETICS; CANCER RESEARCH; CARCINOGENESIS; CHROMOSOME TRANSLOCATION; FEASIBILITY STUDY; GENETIC IDENTIFICATION; HUMAN; NONHUMAN; REVIEW; SOMATIC MUTATION; TRANSPOSON; TUMOR SUPPRESSOR GENE;

EID: 29244433532     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.12.2223     Document Type: Review

References (47)

1. Rous P. A sarcoma of the fowl transmissible by an agent separable from the tumor cells. J Exp Med 1911; 13:397-411.
2. Huebner RJ, Todaro GJ. Oncogenes of rna tumor viruses as determinants of cancer. Proc Natl Acad Sci USA 1969; 64:1087-94.
3. Duesberg PH, Kawai S, Wang LH, Vogt PK, Murphy HM, Hanafusa H. Rna of replication-defective strains of rous sarcoma virus. Proc Natl Acad Sci USA 1975; 72:1569-73.
4. Wang LH, Duesberg PH, Kawai S, Hanafusa H. Location of envelope-specific and sarcoma-specific oligonucleotides on rna of schmidt-ruppin rous sarcoma virus. Proc Natl Acad Sci USA 1976; 73:447-51.
5. Stehelin D, Varmus HE, Bishop JM, Vogt PK. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature 1976; 260:170-3.
6. Tabin CJ, Bradley SM, Bargmann CI, Weinberg RA, Papageorge AG, Scolnick EM, Dhar R, Lowy DR, Chang EH. Mechanism of activation of a human oncogene. Nature 1982; 300:143-9.
7. Parada LF, Tabin CJ, Shih C, Weinberg RA. Human ej bladder carcinoma oncogene is homologue of harvey sarcoma virus ras gene. Nature 1982; 297:474-8.
8. Shih C, Weinberg RA. Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell 1982; 29:161-9.
9. Weinberg RA. One renegade cell: How cancer begins. New York, NY: Basic Books, 1998:170.
10. Harris H, Miller OJ, Klein G, Worst P, Tachibana T. Suppression of malignancy by cell fusion. Nature 1969; 223:363-8.
11. Knudson Jr AG. Mutation and cancer: Statistical study of retinoblastorna. Proc Natl Acad Sci USA 1971; 68:820-3.
12. Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM, Dryja TP. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986; 323:643-6.
13. Dupuy AJ, Akagi K, Largaespada DA, Copeland NG, Jenkins NA. Mammalian mutagenesis using a highly mobile somatic sleeping beauty transposon system. Nature 2005; 436:221-6.
14. Collier LS, Carlson CM, Ravimohan S, Dupuy AJ, Largaespada DA. Cancer gene discovery using sleeping beauty transposon-based somatic mutagenesis in the mouse. Nature 2005; 436:272-6.
15. Nordling CO. A new theory on cancer-inducing mechanism. Br J Cancer 1953; 7:68-72.
16. Armitage P, Doll R. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer 1954; 8:1-12.
17. Armitage P, Doll R. A two-stage theory of carcinogenesis in relation to the age distribution of human cancer. Br J Cancer 1957; 11:161-9.
18. Ashley DJ. The two "hit" and multiple "hit" theories of carcinogenesis. Br J Cancer 1969; 23:313-28.
19. Zhang X, Simon R. Estimating the number of rate limiting genomic changes for human breast cancer. Breast Cancer Res Treat 2005; 91:121-4.
20. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61:759-67.
21. Stoler DL, Chen N, Basik M, Kahlenberg MS, Rodriguez-Bigas MA, Petrelli NJ, Anderson GR. The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc Natl Acad Sci USA 1999; 96:15121-6.
22. Tomlinson I, Sasieni P, Bodmer W. How many mutations in a cancer? Am J Pathol 2002; 160:755-8.
23. Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N, Stratton MR. A census of human cancer genes. Nat Rev Cancer 2004; 4:177-83.
24. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR. Microrna expression profiles classify human cancers. Nature 2005; 435:834-8.
25. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM. Frequent deletions and down-regulation of micro- rna genes mir15 and mir16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002; 99:15524-9.
26. Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Menard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin GA, Querzoli P, Negrini M, Croce CM. Microrna gene expression deregulation in human breast cancer. Cancer Res 2005; 65:7065-70.
27. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y. The transcriptional landscape of the mammalian genome. Science 2005; 309:1559-63.
28. Kampa D, Cheng J, Kapranov P, Yamanaka M, Brubaker S, Cawley S, Drenkow J, Piccolboni A, Bekiranov S, Helt G, Tammana H, Gingeras TR. Novel rnas identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22. Genome Res 2004; 14:331-42.
29. Silva JC, Loreto EL, Clark JB. Factors that affect the horizontal transfer of transposable elements. Curr Issues Mol Biol 2004; 6:57-71.
30. Kidwell MG, Lisch DR. Transposable elements and host genome evolution. Trends In Ecology And Evolution 2000; 15:95-99.
31. Li WH, Gu Z, Wang H, Nekrutenko A. Evolutionary analyses of the human genome. Nature 2001; 409:847-9.
32. Ivics Z, Izsvak Z. Transposable elements for transgenesis and insertional mutagenesis in vertebrates. In: Miller WJ, Capy P, eds. Mobile Genetic Elements. Totowa, NJ: Humana Press, 2004:xii:289.
33. Ivics Z, Hackett PB, Plasterk RH, Izsvak Z. Molecular reconstruction of sleeping beauty, a tc1-like transposon from fish, and its transposition in human cells. Cell 1997; 91:501-10.
34. Izsvak Z, Ivics Z. Sleeping beauty transposition: Biology and applications for molecular therapy. Mol Ther 2004; 9:147-56.
35. Dupuy AJ, Fritz S, Largaespada DA. Transposition and gene disruption in the male germline of the mouse. Genesis 2001; 30:82-8.
36. Carlson CM, Dupuy AJ, Fritz S, Roberg-Perez KJ, Fletcher CF, Largaespada DA. Transposon mutagenesis of the mouse germline. Genetics 2003; 165:243-56.
37. Rubin GM, Kidwell MG, Bingham PM. The molecular basis of p-m hybrid dysgenesis: The nature of induced mutations. Cell 1982; 29:987-94.
38. Bingham PM, Kidwell MG, Rubin GM. The molecular basis of p-m hybrid dysgenesis: The role of the p element, a p-strain-specific transposon family. Cell 1982; 29:995-1004.
39. Castro JP, Carareto CM. Drosophila melanogaster p transposable elements: Mechanisms of transposition and regulation. Genetica 2004; 121:107-18.
40. Weng AP, Ferrando AA, Lee W, Morris JPT, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of notch1 in human t cell acute lymphoblastic leukemia. Science 2004; 306:269-71.
41. Luo G, Santoro IM, McDaniel LD, Nishijima I, Mills M, Youssoufian H, Vogel H, Schultz RA, Bradley A. Cancer predisposition caused by elevated mitotic recombination in bloom mice. Nat Genet 2000; 26:424-9.
42. O'Hagan RC, Chang S, Maser RS, Mohan R, Artandi SE, Chin L, DePinho RA. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2002; 2:149-55.
43. Dumon-Jones V, Frappart PO, Tong WM, Sajithlal G, Hulla W, Schmid G, Herceg Z, Digweed M, Wang ZQ. Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis. Cancer Res 2003; 63:7263-9.
44. Belur LR, Frandsen JL, Dupuy AJ, Ingbar DH, Largaespada DA, Hackett PB, Scott Mclvor R. Gene insertion and long-term expression in lung mediated by the sleeping beauty transposon system. Mol Ther 2003; 8:501-7.
45. Geurts AM, Yang Y, Clark KJ, Liu G, Cui Z, Dupuy AJ, Bell JB, Largaespada DA, Hackett PB. Gene transfer into genomes of human cells by the sleeping beauty transposon system. Mol Ther 2003; 8:108-17.
46. Heggestad AD, Notterpek L, Fletcher BS. Transposon-based rnai delivery system for generating knockdown cell lines. Biochem Biophys Res Commun 2004; 316:643-50.
47. Carlson CM. Somatic integration of an oncogene-harboring sleeping beauty transposon to model tumors in the mouse. Submitted 2005.