메뉴 건너뛰기




Volumn 12, Issue 4, 2005, Pages 721-747

Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANASTROZOLE; ANTIESTROGEN; AROMATASE INHIBITOR; CYCLOPHOSPHAMIDE; DOXORUBICIN; ERLOTINIB; ESTROGEN; ESTROGEN RECEPTOR ALPHA; EXEMESTANE; FLUOROURACIL; FULVESTRANT; GEFITINIB; GROWTH FACTOR; LAPATINIB; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MEGESTROL ACETATE; N BUTYL 11 (3,17BETA DIHYDROXYESTRA 1,3,5(10) TRIEN 7ALPHA YL) N METHYLUNDECANAMIDE; PAROXETINE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SEROTONIN UPTAKE INHIBITOR; TAMOXIFEN; TOREMIFENE; TRASTUZUMAB;

EID: 29144526402     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.1.00857     Document Type: Review
Times cited : (246)

References (170)
  • 2
    • 4444278403 scopus 로고    scopus 로고
    • HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: A Southwest Oncology Group Study
    • Arpino G, Green SJ, Allred DC, Lew D, Martino S, Osborne CK & Elledge RM 2004 HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a Southwest Oncology Group Study. Clinical Cancer Research 10 5670-5676.
    • (2004) Clinical Cancer Research , vol.10 , pp. 5670-5676
    • Arpino, G.1    Green, S.J.2    Allred, D.C.3    Lew, D.4    Martino, S.5    Osborne, C.K.6    Elledge, R.M.7
  • 3
    • 18444362087 scopus 로고    scopus 로고
    • ECOG1100: A phase I-II study of combined blockade of the erbB receptor network with trastuzmab and gefitinib ('Iressa') in patients (pts) with HER2-overexpressing metastatic breast cancer
    • abstract 25
    • Arteaga CL, O'Neil A, Moulder SL, Pins M, Sparano JA, Sledge GW & Davidson NE 2004 ECOG1100: a phase I-II study of combined blockade of the erbB receptor network with trastuzmab and gefitinib ('Iressa') in patients (pts) with HER2-overexpressing metastatic breast cancer. Breast Cancer Research and Treatment 88 S1 S15-16 (abstract 25).
    • (2004) Breast Cancer Research and Treatment , vol.88 S1
    • Arteaga, C.L.1    O'Neil, A.2    Moulder, S.L.3    Pins, M.4    Sparano, J.A.5    Sledge, G.W.6    Davidson, N.E.7
  • 4
    • 0037226817 scopus 로고    scopus 로고
    • Heregulin is sufficient for the promotion of tumorigenecity and metastasis of breast cancer in vivo
    • Atlas E, Cardillo M, Mehmi I, Zahedkargaran H, Tang C & Lupu R 2003 Heregulin is sufficient for the promotion of tumorigenecity and metastasis of breast cancer in vivo. Molecular Cancer Resarch 1 165-175.
    • (2003) Molecular Cancer Resarch , vol.1 , pp. 165-175
    • Atlas, E.1    Cardillo, M.2    Mehmi, I.3    Zahedkargaran, H.4    Tang, C.5    Lupu, R.6
  • 5
    • 0038688478 scopus 로고    scopus 로고
    • Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases
    • Bardou VJ, Arpino G, Elledge RM, Osborne CK & Clark GM 2003 Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases. Journal of Clinical Oncology 21 1973-1979.
    • (2003) Journal of Clinical Oncology , vol.21 , pp. 1973-1979
    • Bardou, V.J.1    Arpino, G.2    Elledge, R.M.3    Osborne, C.K.4    Clark, G.M.5
  • 6
    • 0037157603 scopus 로고    scopus 로고
    • Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: First results of the ATAC randomised trial
    • Baum M, Budzar AU, Cuzick J, Forbes J, Houghton JH, Klijn JG & Sahmoud T; ATAC Trialists' Group 2002 Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet 359 2131-2139.
    • (2002) Lancet , vol.359 , pp. 2131-2139
    • Baum, M.1    Budzar, A.U.2    Cuzick, J.3    Forbes, J.4    Houghton, J.H.5    Klijn, J.G.6    Sahmoud, T.7
  • 10
    • 29144515053 scopus 로고    scopus 로고
    • Letrozole versus tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive breast cancer. BIG 1-98: A prospective randomized double-blind phase III study
    • St Gallen, Switzerland. Abstract S4
    • BIG 1-98 Collaborative Group 2005 Letrozole versus tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive breast cancer. BIG 1-98: a prospective randomized double-blind phase III study. Proceedings of the 9th International Conference, Primary Therapy of Early Breast Cancer, St Gallen, Switzerland. Abstract S4.
    • (2005) Proceedings of the 9th International Conference, Primary Therapy of Early Breast Cancer
  • 12
    • 1542294319 scopus 로고    scopus 로고
    • Anastrozole appears to be superior to tamoxifen in women already receiving adjuvant tamoxifen treatment
    • Boccardo F, Rubagotti A & Amoroso D, on behalf of the Italian Tamoxifen Arimidex (ITA) trial 2003 Anastrozole appears to be superior to tamoxifen in women already receiving adjuvant tamoxifen treatment. Breast Cancer Research and Treatment 82 S6.
    • (2003) Breast Cancer Research and Treatment , vol.82
    • Boccardo, F.1    Rubagotti, A.2    Amoroso, D.3
  • 17
    • 0029877913 scopus 로고    scopus 로고
    • Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
    • Bunone G, Briand PA, Miksicek RJ & Picard D 1996 Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO Journal 15 2174-2183.
    • (1996) EMBO Journal , vol.15 , pp. 2174-2183
    • Bunone, G.1    Briand, P.A.2    Miksicek, R.J.3    Picard, D.4
  • 18
    • 0032530988 scopus 로고    scopus 로고
    • Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: Results of a survival update based on a combined analysis of data from two mature phase III trials
    • Arimidex Study Group
    • Buzdar AU, Jonat W, Howell A, Jones SE, Blomqvist CP, Vogel CL, Eiermann W, Wolter JM, Steinberg M, Webster A & Lee D 1998 Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: results of a survival update based on a combined analysis of data from two mature phase III trials. Arimidex Study Group. Cancer 83 1142-1152.
    • (1998) Cancer , vol.83 , pp. 1142-1152
    • Buzdar, A.U.1    Jonat, W.2    Howell, A.3    Jones, S.E.4    Blomqvist, C.P.5    Vogel, C.L.6    Eiermann, W.7    Wolter, J.M.8    Steinberg, M.9    Webster, A.10    Lee, D.11
  • 22
    • 0034238115 scopus 로고    scopus 로고
    • Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen- mediated cell cycle arrest in human breast cancer cells
    • Cariou S, Donovan JC, Flanagan WM, Milic A, Bhattacharya N & Slingerland JM 2000 Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells. PNAS 97 9042-9046.
    • (2000) PNAS , vol.97 , pp. 9042-9046
    • Cariou, S.1    Donovan, J.C.2    Flanagan, W.M.3    Milic, A.4    Bhattacharya, N.5    Slingerland, J.M.6
  • 24
    • 0036702132 scopus 로고    scopus 로고
    • Molecular changes associated with the acquisition of estrogen hypersensitivity in MCF-7 breast cancer cells on long-term estrogen deprivation
    • Chan CM, Martin LA, Johnston SR, Ali S & Dowsett M 2002 Molecular changes associated with the acquisition of estrogen hypersensitivity in MCF-7 breast cancer cells on long-term estrogen deprivation. Journal of Steroid Biochemistry and Molecular Biology 81 333-341.
    • (2002) Journal of Steroid Biochemistry and Molecular Biology , vol.81 , pp. 333-341
    • Chan, C.M.1    Martin, L.A.2    Johnston, S.R.3    Ali, S.4    Dowsett, M.5
  • 25
    • 0029097233 scopus 로고
    • A transcriptional co-repressor that interacts with nuclear hormone receptors
    • Chen JD & Evans RM 1995 A transcriptional co-repressor that interacts with nuclear hormone receptors Nature 377 454-457.
    • (1995) Nature , vol.377 , pp. 454-457
    • Chen, J.D.1    Evans, R.M.2
  • 26
    • 0041317555 scopus 로고    scopus 로고
    • Endocrine response after prior treatment with fulvestrant ('Faslodex') in postmenopausal women with advanced breast cancer
    • Cheung KL, Robertson JF & Scott N 2002 Endocrine response after prior treatment with fulvestrant ('Faslodex') in postmenopausal women with advanced breast cancer. European Journal of Cancer 38 S98.
    • (2002) European Journal of Cancer , vol.38
    • Cheung, K.L.1    Robertson, J.F.2    Scott, N.3
  • 27
    • 0037137898 scopus 로고    scopus 로고
    • Resistance to tamoxifen-induced apoptosis is associated with direct interaction between Her2/neu and cell membrane estrogen receptor in breast cancer
    • Chung YL, Sheu ML, Yang SC, Lin CH & Yen SH 2002 Resistance to tamoxifen-induced apoptosis is associated with direct interaction between Her2/neu and cell membrane estrogen receptor in breast cancer. International Journal of Cancer 97 306-312.
    • (2002) International Journal of Cancer , vol.97 , pp. 306-312
    • Chung, Y.L.1    Sheu, M.L.2    Yang, S.C.3    Lin, C.H.4    Yen, S.H.5
  • 28
    • 0024516490 scopus 로고
    • The effects of a constitutive expression of transforming growth factor-alpha on the growth of MCF-7 human breast cancer cells in vitro and in vivo
    • Clarke R, Brunner N, Katz D, Glanz P, Dickson RB, Lippman ME & Kern FG 1989 The effects of a constitutive expression of transforming growth factor-alpha on the growth of MCF-7 human breast cancer cells in vitro and in vivo. Molecular Endocrinology 3 372-380.
    • (1989) Molecular Endocrinology , vol.3 , pp. 372-380
    • Clarke, R.1    Brunner, N.2    Katz, D.3    Glanz, P.4    Dickson, R.B.5    Lippman, M.E.6    Kern, F.G.7
  • 30
    • 0037385522 scopus 로고    scopus 로고
    • Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: Progesterone receptor as a potential indicator of growth factor activity in breast cancer
    • Cui X, Zhang P, Deng W, Oesterreich S, Lu Y, Mills GB & Lee AV 2003 Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer. Molecular Endocrinology 17 575-588.
    • (2003) Molecular Endocrinology , vol.17 , pp. 575-588
    • Cui, X.1    Zhang, P.2    Deng, W.3    Oesterreich, S.4    Lu, Y.5    Mills, G.B.6    Lee, A.V.7
  • 31
    • 0033740191 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells
    • Davis T, Kennedy C, Chiew YE, Clarke CL & deFazio A 2000 Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells. Clinical Cancer Research 6 4334-4342.
    • (2000) Clinical Cancer Research , vol.6 , pp. 4334-4342
    • Davis, T.1    Kennedy, C.2    Chiew, Y.E.3    Clarke, C.L.4    DeFazio, A.5
  • 33
    • 0031943424 scopus 로고    scopus 로고
    • Letrozole, a new oral aromatase inhibitor for advanced breast cancer: Double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate
    • Dombernowsky P, Smith I, Falkson G, Leonard R, Panasci L, Bellmunt J, Bezwoda W, Gardin G, Gudgeon A, Morgan M et al. 1998 Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate. Journal of Clinical Oncology 16 453-461.
    • (1998) Journal of Clinical Oncology , vol.16 , pp. 453-461
    • Dombernowsky, P.1    Smith, I.2    Falkson, G.3    Leonard, R.4    Panasci, L.5    Bellmunt, J.6    Bezwoda, W.7    Gardin, G.8    Gudgeon, A.9    Morgan, M.10
  • 34
    • 1542354356 scopus 로고    scopus 로고
    • Analysis of time to recurrence in the ATAC (Arimidex, tamoxifen, alone or in combination) trial according to estrogen receptor and progesterone receptor status
    • Dowsett M 2003 Analysis of time to recurrence in the ATAC (Arimidex, tamoxifen, alone or in combination) trial according to estrogen receptor and progesterone receptor status. Breast Cancer Research and Treatment 82 S7.
    • (2003) Breast Cancer Research and Treatment , vol.82
    • Dowsett, M.1
  • 36
    • 0032537396 scopus 로고    scopus 로고
    • Tamoxifen for early breast cancer: An overview of the randomised trials
    • Early Breast Cancer Trialist Group 1998 Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 351 1461-1467.
    • (1998) Lancet , vol.351 , pp. 1461-1467
  • 37
    • 0030757687 scopus 로고    scopus 로고
    • Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis
    • El-Ashry D, Miller DL, Kharbanda S, Lippman ME & Kern FG 1997 Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis. Oncogene 15 423-435.
    • (1997) Oncogene , vol.15 , pp. 423-435
    • El-Ashry, D.1    Miller, D.L.2    Kharbanda, S.3    Lippman, M.E.4    Kern, F.G.5
  • 40
    • 2942565669 scopus 로고    scopus 로고
    • Overcoming endocrine therapy resistance by signal transduction inhibition
    • Ellis M 2004 Overcoming endocrine therapy resistance by signal transduction inhibition. Oncologist 9 20-26.
    • (2004) Oncologist , vol.9 , pp. 20-26
    • Ellis, M.1
  • 42
    • 16544365765 scopus 로고    scopus 로고
    • Quality of life of postmenopausal women in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Adjuvant Breast Cancer Trial
    • Fallowfield L, Cella D, Cuzick J, Francis S, Locker G & Howell A 2004 Quality of life of postmenopausal women in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Adjuvant Breast Cancer Trial. Journal of Clinical Oncology 22 4261-4271.
    • (2004) Journal of Clinical Oncology , vol.22 , pp. 4261-4271
    • Fallowfield, L.1    Cella, D.2    Cuzick, J.3    Francis, S.4    Locker, G.5    Howell, A.6
  • 43
    • 0037339988 scopus 로고    scopus 로고
    • The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182780 in ERalpha-positive breast cancer cells
    • Fan M, Bigsby RM & Nephew KP 2003 The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182780 in ERalpha-positive breast cancer cells. Molecular Endocrinology 17 356-365.
    • (2003) Molecular Endocrinology , vol.17 , pp. 356-365
    • Fan, M.1    Bigsby, R.M.2    Nephew, K.P.3
  • 44
    • 0001392322 scopus 로고    scopus 로고
    • AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor
    • Font de Mora J & Brown M 2000 AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Molecular and Cellular Biology 20 5041-5047.
    • (2000) Molecular and Cellular Biology , vol.20 , pp. 5041-5047
    • Font De Mora, J.1    Brown, M.2
  • 45
    • 0141785350 scopus 로고    scopus 로고
    • Profiling of estrogen up- And down-regulated gene expression in human breast cancer cells: Insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype
    • Frasor J, Danes JM, Komm B, Chang KCN, Lyttle R & Katzenellenbogen BS 2003 Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 144 4562-4574.
    • (2003) Endocrinology , vol.144 , pp. 4562-4574
    • Frasor, J.1    Danes, J.M.2    Komm, B.3    Chang, K.C.N.4    Lyttle, R.5    Katzenellenbogen, B.S.6
  • 47
    • 0035919923 scopus 로고    scopus 로고
    • Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer
    • Gee JM, Robertson JF, Ellis IO & Nicholson RI 2001 Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer. International Journal of Cancer 95 247-254.
    • (2001) International Journal of Cancer , vol.95 , pp. 247-254
    • Gee, J.M.1    Robertson, J.F.2    Ellis, I.O.3    Nicholson, R.I.4
  • 51
    • 0023760993 scopus 로고
    • Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration
    • Gottardis MM & Jordan VC 1988 Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Research 48 5183-5187.
    • (1988) Cancer Research , vol.48 , pp. 5183-5187
    • Gottardis, M.M.1    Jordan, V.C.2
  • 52
    • 0024319781 scopus 로고
    • Inhibition of tarnoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens
    • Gottardis MM, Jiang SY, Jeng MH, Jordan VC 1989 Inhibition of tarnoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens. Cancer Research 49 4090-4093.
    • (1989) Cancer Research , vol.49 , pp. 4090-4093
    • Gottardis, M.M.1    Jiang, S.Y.2    Jeng, M.H.3    Jordan, V.C.4
  • 53
    • 3542996262 scopus 로고    scopus 로고
    • Tamoxifen - What next?
    • Gradishar WJ 2004 Tamoxifen - What next? Oncologist 9 378-384.
    • (2004) Oncologist , vol.9 , pp. 378-384
    • Gradishar, W.J.1
  • 54
    • 0026343481 scopus 로고
    • Transcription activation by estrogen and progesterone receptors
    • Gronemeyer H 1991 Transcription activation by estrogen and progesterone receptors. Annual Review of Genetics 25 89-123.
    • (1991) Annual Review of Genetics , vol.25 , pp. 89-123
    • Gronemeyer, H.1
  • 56
    • 0033304993 scopus 로고    scopus 로고
    • The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens
    • Hall JM & McDonnell DP 1999 The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 140 5566-5578.
    • (1999) Endocrinology , vol.140 , pp. 5566-5578
    • Hall, J.M.1    McDonnell, D.P.2
  • 57
    • 10644274482 scopus 로고    scopus 로고
    • Estrogen receptor mutations in human disease
    • Herynk MH & Fuqua SA 2004 Estrogen receptor mutations in human disease. Endocrine Reviews 25 869-898.
    • (2004) Endocrine Reviews , vol.25 , pp. 869-898
    • Herynk, M.H.1    Fuqua, S.A.2
  • 59
    • 0032982818 scopus 로고    scopus 로고
    • Overexpression of c-erbB2 is an independent marker of resistance to endocrine therapy in advanced breast cancer
    • Houston SJ, Plunkett TA, Barnes DM, Smith P, Rubens RD & Miles DW 1999 Overexpression of c-erbB2 is an independent marker of resistance to endocrine therapy in advanced breast cancer. British Journal of Cancer 79 1220-1226.
    • (1999) British Journal of Cancer , vol.79 , pp. 1220-1226
    • Houston, S.J.1    Plunkett, T.A.2    Barnes, D.M.3    Smith, P.4    Rubens, R.D.5    Miles, D.W.6
  • 62
    • 2442648038 scopus 로고    scopus 로고
    • Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: A multinational, double-blind, randomized trial
    • Howell A, Robertson JF, Abram P, Lichinitser MR, Elledge R, Bajetta E, Watanabe T, Morris C, Webster A, Dimery I & Osborne CK 2004 Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trial. Journal of Clinical Oncology 22 1605-1613.
    • (2004) Journal of Clinical Oncology , vol.22 , pp. 1605-1613
    • Howell, A.1    Robertson, J.F.2    Abram, P.3    Lichinitser, M.R.4    Elledge, R.5    Bajetta, E.6    Watanabe, T.7    Morris, C.8    Webster, A.9    Dimery, I.10    Osborne, C.K.11
  • 63
    • 11444251764 scopus 로고    scopus 로고
    • Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer
    • Howell A, Cuzick J, Baum M, Buzdar A, Dowsett M, Forbes JF, Hoctin-Boes G, Houghton J, Locker GY & Tobias JS; ATAC Trialists' Group 2005 Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet 365 60-62.
    • (2005) Lancet , vol.365 , pp. 60-62
    • Howell, A.1    Cuzick, J.2    Baum, M.3    Buzdar, A.4    Dowsett, M.5    Forbes, J.F.6    Hoctin-Boes, G.7    Houghton, J.8    Locker, G.Y.9    Tobias, J.S.10
  • 66
    • 18944365812 scopus 로고    scopus 로고
    • Evaluation of fulvestrant in women with advanced breast cancer and progression on prior aromatase inhibitor therapy: A phase II trial of the North Central Cancer Treatment Group
    • Ingle JN, Rowland KM, Suman VJ, Mirchandani D, Bernath AM, Camoriano JK & Perez EA 2004 Evaluation of fulvestrant in women with advanced breast cancer and progression on prior aromatase inhibitor therapy: a phase II trial of the North Central Cancer Treatment Group. Breast Cancer Research and Treatment 88 S38.
    • (2004) Breast Cancer Research and Treatment , vol.88
    • Ingle, J.N.1    Rowland, K.M.2    Suman, V.J.3    Mirchandani, D.4    Bernath, A.M.5    Camoriano, J.K.6    Perez, E.A.7
  • 67
    • 14544273687 scopus 로고    scopus 로고
    • Benefits of switching postmenopausal women with hormone-sensitive early breast cancer to anastrozole after 2 years adjuvant tamoxifen: Combined results from 3123 women enrolled in the ABCSG Trial and the ARNO 95 Trial
    • Jakesz R, Kaufmann M, Gnant M, Jonat W, Mittlboeck M, Greil R, Tausch C, Hilfrich J, Kwasny W & Samonigg H 2004 Benefits of switching postmenopausal women with hormone-sensitive early breast cancer to anastrozole after 2 years adjuvant tamoxifen: combined results from 3123 women enrolled in the ABCSG Trial and the ARNO 95 Trial. Breast Cancer Research and Treatment 88 S7.
    • (2004) Breast Cancer Research and Treatment , vol.88
    • Jakesz, R.1    Kaufmann, M.2    Gnant, M.3    Jonat, W.4    Mittlboeck, M.5    Greil, R.6    Tausch, C.7    Hilfrich, J.8    Kwasny, W.9    Samonigg, H.10
  • 69
    • 12144255062 scopus 로고    scopus 로고
    • Combinations of endocrine and biological agents: Present status of therapeutic and presurgical investigations
    • Johnston SR 2005 Combinations of endocrine and biological agents: present status of therapeutic and presurgical investigations. Clinical Cancer Research 11 889-899s.
    • (2005) Clinical Cancer Research , vol.11
    • Johnston, S.R.1
  • 70
    • 0242499440 scopus 로고    scopus 로고
    • Aromatase inhibitors for breast cancer: Lessons from the laboratory
    • Johnston SR & Dowsett M 2003 Aromatase inhibitors for breast cancer: lessons from the laboratory. Nature Reviews Cancer 3 821-831.
    • (2003) Nature Reviews Cancer , vol.3 , pp. 821-831
    • Johnston, S.R.1    Dowsett, M.2
  • 77
    • 0035879210 scopus 로고    scopus 로고
    • Value of epidermal growth factor receptor, HER2, p53, and steroid receptors in predicting the efficacy of tamoxifen in high-risk postmenopausal breast cancer patients
    • Knoop AS, Bentzen SM, Nielsen MM, Rasmussen BB & Rose C 2001 Value of epidermal growth factor receptor, HER2, p53, and steroid receptors in predicting the efficacy of tamoxifen in high-risk postmenopausal breast cancer patients. Journal of Clinical Oncology 19 3376-3384.
    • (2001) Journal of Clinical Oncology , vol.19 , pp. 3376-3384
    • Knoop, A.S.1    Bentzen, S.M.2    Nielsen, M.M.3    Rasmussen, B.B.4    Rose, C.5
  • 78
    • 0037373326 scopus 로고    scopus 로고
    • Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    • Knowlden JM, Hutcheson IR, Jones HE, Madden T, Gee JM, Harper ME, Barrow D, Wakeling AE & Nicholson RI 2003a Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 144 1032-1044.
    • (2003) Endocrinology , vol.144 , pp. 1032-1044
    • Knowlden, J.M.1    Hutcheson, I.R.2    Jones, H.E.3    Madden, T.4    Gee, J.M.5    Harper, M.E.6    Barrow, D.7    Wakeling, A.E.8    Nicholson, R.I.9
  • 80
    • 0034667395 scopus 로고    scopus 로고
    • Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells
    • Kurokawa H, Lenferink AE, Simpson JF, Pisacane PI, Sliwkowski MX, Forbes JT & Arteaga CL 2000 Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Cancer Research 60 5887-5894.
    • (2000) Cancer Research , vol.60 , pp. 5887-5894
    • Kurokawa, H.1    Lenferink, A.E.2    Simpson, J.F.3    Pisacane, P.I.4    Sliwkowski, M.X.5    Forbes, J.T.6    Arteaga, C.L.7
  • 83
    • 0034615669 scopus 로고    scopus 로고
    • The SRC family of nuclear receptor coactivators
    • Leo C & Chen JD 2000 The SRC family of nuclear receptor coactivators. Gene 245 1-11.
    • (2000) Gene , vol.245 , pp. 1-11
    • Leo, C.1    Chen, J.D.2
  • 84
    • 0037338707 scopus 로고    scopus 로고
    • Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor
    • Levin ER 2003 Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor. Molecular Endocrinology 17 309-317.
    • (2003) Molecular Endocrinology , vol.17 , pp. 309-317
    • Levin, E.R.1
  • 86
    • 0028928063 scopus 로고
    • MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen dependence and tamoxifen-sensitivity in vivo
    • Liu Y, El-Ashry D, Chen D, Ding IY & Kern FG 1995 MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen dependence and tamoxifen-sensitivity in vivo. Breast Cancer Research and Treatment 34 97-117.
    • (1995) Breast Cancer Research and Treatment , vol.34 , pp. 97-117
    • Liu, Y.1    El-Ashry, D.2    Chen, D.3    Ding, I.Y.4    Kern, F.G.5
  • 87
    • 0035992421 scopus 로고    scopus 로고
    • The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: Long-term studies using the intratumoral aromatase postmenopausal breast cancer model
    • Long BJ, Jelovac D, Thiantanawat A & Brodie AM 2002 The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model. Clinical Cancer Research 8 2378-2388.
    • (2002) Clinical Cancer Research , vol.8 , pp. 2378-2388
    • Long, B.J.1    Jelovac, D.2    Thiantanawat, A.3    Brodie, A.M.4
  • 89
    • 7444235451 scopus 로고    scopus 로고
    • Combining the farnesyl transferase inhibitor (FTI) Lonafarnib (SCH66336) with antiestrogens and aromatase inhibitors results in enhanced growth inhibition of hormone-dependent human breast cancer cells and tumor xenografts
    • Long BJ, Liu G, Marrinan CH, Maxwell E, Black S, Gheyas F, Nomeir A, Liu M, Kirschmeier P & Bishop WR 2004b Combining the farnesyl transferase inhibitor (FTI) Lonafarnib (SCH66336) with antiestrogens and aromatase inhibitors results in enhanced growth inhibition of hormone-dependent human breast cancer cells and tumor xenografts. Proceedings of the American Association for Cancer Research 45 A3868.
    • (2004) Proceedings of the American Association for Cancer Research , vol.45
    • Long, B.J.1    Liu, G.2    Marrinan, C.H.3    Maxwell, E.4    Black, S.5    Gheyas, F.6    Nomeir, A.7    Liu, M.8    Kirschmeier, P.9    Bishop, W.R.10
  • 90
    • 3042545132 scopus 로고    scopus 로고
    • Aromatase inhibitors in breast cancer
    • Lonning PE 2004 Aromatase inhibitors in breast cancer. Endocrine-Related Cancer 11 179-189.
    • (2004) Endocrine-Related Cancer , vol.11 , pp. 179-189
    • Lonning, P.E.1
  • 91
    • 0038304456 scopus 로고    scopus 로고
    • pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1- DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer
    • Macaluso M, Cinti C, Russo G, Russo A & Giordano A 2003 pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer. Oncogene 22 3511-3517.
    • (2003) Oncogene , vol.22 , pp. 3511-3517
    • Macaluso, M.1    Cinti, C.2    Russo, G.3    Russo, A.4    Giordano, A.5
  • 92
    • 0034987631 scopus 로고    scopus 로고
    • Enhanced epidermal growth factor receptor signaling in MCF-7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182 780 (Faslodex)
    • McClelland RA, Barrow D, Madden TA, Dutkowski CM, Pamment J, Knowlden JM, Gee JM & Nicholson RI 2001 Enhanced epidermal growth factor receptor signaling in MCF-7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182 780 (Faslodex). Endocrinology 142 2776-2788.
    • (2001) Endocrinology , vol.142 , pp. 2776-2788
    • McClelland, R.A.1    Barrow, D.2    Madden, T.A.3    Dutkowski, C.M.4    Pamment, J.5    Knowlden, J.M.6    Gee, J.M.7    Nicholson, R.I.8
  • 93
    • 12144262323 scopus 로고    scopus 로고
    • The molecular pharmacology of estrogen receptor modulators: Implications for the treatment of breast cancer
    • McDonnell DP 2005 The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer. Clinical Cancer Research 11 871-877s.
    • (2005) Clinical Cancer Research , vol.11
    • McDonnell, D.P.1
  • 94
    • 0029038986 scopus 로고
    • Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens
    • McDonnel DP, Clemm DL, Hermann T, Goldman ME & Pike JW 1995 Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Molecular Endocrinology 9 659-669.
    • (1995) Molecular Endocrinology , vol.9 , pp. 659-669
    • McDonnel, D.P.1    Clemm, D.L.2    Hermann, T.3    Goldman, M.E.4    Pike, J.W.5
  • 95
    • 0033305547 scopus 로고    scopus 로고
    • Nuclear receptor coregulators: Cellular and molecular biology
    • McKenna NJ, Lanz RB & O'Malley BW 1999 Nuclear receptor coregulators: cellular and molecular biology. Endocrine Reviews 20 321-344.
    • (1999) Endocrine Reviews , vol.20 , pp. 321-344
    • McKenna, N.J.1    Lanz, R.B.2    O'Malley, B.W.3
  • 96
    • 0042232592 scopus 로고    scopus 로고
    • Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation
    • Martin LA, Farmer I, Johnston SR, Ali S, Marshall C & Dowsett M 2003 Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation. Journal of Biological Chemistry 278 30458-30468.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 30458-30468
    • Martin, L.A.1    Farmer, I.2    Johnston, S.R.3    Ali, S.4    Marshall, C.5    Dowsett, M.6
  • 99
    • 0000897357 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor/HER2 receptor signaling using ZD1839 ('Iressa') restores tamoxifen sensitivity and delays resistance to estrogen deprivation in HER2-overexpressing breast tumors
    • abstract 130
    • Massarweh S, Shou J, Mohsin SK, Ge M, Wakeling AE, Osborne CK & Schiff R 2002 Inhibition of epidermal growth factor/HER2 receptor signaling using ZD1839 ('Iressa') restores tamoxifen sensitivity and delays resistance to estrogen deprivation in HER2-overexpressing breast tumors. Proceedings of the American Society of Clinical Oncology 21 (abstract 130).
    • (2002) Proceedings of the American Society of Clinical Oncology , vol.21
    • Massarweh, S.1    Shou, J.2    Mohsin, S.K.3    Ge, M.4    Wakeling, A.E.5    Osborne, C.K.6    Schiff, R.7
  • 101
    • 0035893560 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo
    • Moulder SL, Yakes FM, Muthuswamy SK, Bianco R, Simpson JF & Arteaga CL 2001 Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Research 61 8887-8895.
    • (2001) Cancer Research , vol.61 , pp. 8887-8895
    • Moulder, S.L.1    Yakes, F.M.2    Muthuswamy, S.K.3    Bianco, R.4    Simpson, J.F.5    Arteaga, C.L.6
  • 104
    • 0034669484 scopus 로고    scopus 로고
    • Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: Results of a North American multicenter randomized trial
    • Arimidex Study Group
    • Nabholtz JM, Buzdar A, Pollak M, Harwin W, Burton G, Mangalik A, Steinberg M, Webster A & von Euler M 2000 Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. Arimidex Study Group. Journal of Clinical Oncology 18 3758-3767.
    • (2000) Journal of Clinical Oncology , vol.18 , pp. 3758-3767
    • Nabholtz, J.M.1    Buzdar, A.2    Pollak, M.3    Harwin, W.4    Burton, G.5    Mangalik, A.6    Steinberg, M.7    Webster, A.8    Von Euler, M.9
  • 105
    • 11244250660 scopus 로고    scopus 로고
    • Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: New opportunities for therapy
    • Nicholson RI, Staka C, Boyns F, Hutcheson IR & Gee JM 2004 Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy. Endocrine-Related Cancer 11 623-641.
    • (2004) Endocrine-Related Cancer , vol.11 , pp. 623-641
    • Nicholson, R.I.1    Staka, C.2    Boyns, F.3    Hutcheson, I.R.4    Gee, J.M.5
  • 110
    • 11244334282 scopus 로고    scopus 로고
    • Small molecule epidermal growth factor receptor tyrosine kinase inhibitors: An overview
    • Normanno N, Maiello MR, Mancino M & De Luca A 2004b Small molecule epidermal growth factor receptor tyrosine kinase inhibitors: an overview. Journal of Chemotherapy 16 (Suppl 4) 36-40.
    • (2004) Journal of Chemotherapy , vol.16 , Issue.SUPPL. 4 , pp. 36-40
    • Normanno, N.1    Maiello, M.R.2    Mancino, M.3    De Luca, A.4
  • 112
    • 15544379599 scopus 로고    scopus 로고
    • Estrogen-receptor biology: Continuing progress and therapeutic implications
    • Osborne CK & Schiff R 2005 Estrogen-receptor biology: continuing progress and therapeutic implications. Journal of Clinical Oncology 23 1616-1622.
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 1616-1622
    • Osborne, C.K.1    Schiff, R.2
  • 113
    • 0026068370 scopus 로고
    • Acquired tamoxifen resistance: Correlation with reduced breast tumor levels of tamoxifen and isomerization of trans-4-hydroxytamoxifen
    • Osborne CK, Coronado E, Allred DC, Wiebe V & DeGregorio M 1991 Acquired tamoxifen resistance: correlation with reduced breast tumor levels of tamoxifen and isomerization of trans-4-hydroxytamoxifen. Journal of the National Cancer Institute 83 1477-1482.
    • (1991) Journal of the National Cancer Institute , vol.83 , pp. 1477-1482
    • Osborne, C.K.1    Coronado, E.2    Allred, D.C.3    Wiebe, V.4    DeGregorio, M.5
  • 115
  • 116
  • 118
    • 12144269500 scopus 로고    scopus 로고
    • Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer
    • Osborne CK, Shou J, Massarweh S & Schiff R 2005 Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer. Clinical Cancer Research 11 865-870s.
    • (2005) Clinical Cancer Research , vol.11
    • Osborne, C.K.1    Shou, J.2    Massarweh, S.3    Schiff, R.4
  • 119
    • 0028318783 scopus 로고
    • Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells
    • Ottaviano YL, Issa JP, Parl FF, Smith HS, Baylin SB & Davidson NE 1994 Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Research 54 2552-2555.
    • (1994) Cancer Research , vol.54 , pp. 2552-2555
    • Ottaviano, Y.L.1    Issa, J.P.2    Parl, F.F.3    Smith, H.S.4    Baylin, S.B.5    Davidson, N.E.6
  • 122
    • 0242659275 scopus 로고    scopus 로고
    • Multiple mechanisms of estrogen receptor gene repression contribute to ER-negative breast cancer
    • Parl FF 2003 Multiple mechanisms of estrogen receptor gene repression contribute to ER-negative breast cancer Pharmacogenomics Journal 3 251-253.
    • (2003) Pharmacogenomics Journal , vol.3 , pp. 251-253
    • Parl, F.F.1
  • 124
    • 18244391514 scopus 로고    scopus 로고
    • Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
    • Perez-Tenorio G & Stal O; Southeast Sweden Breast Cancer Group 2002 Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. British Journal of Cancer 86 540-545.
    • (2002) British Journal of Cancer , vol.86 , pp. 540-545
    • Perez-Tenorio, G.1    Stal, O.2
  • 125
    • 0034641862 scopus 로고    scopus 로고
    • Estrogen receptor β acts as a dominant regulator of estrogen signalling
    • Pettersson K, Delaunay F & Gustafsson JA 2000 Estrogen receptor β acts as a dominant regulator of estrogen signalling. Oncogene 19 4970-4978.
    • (2000) Oncogene , vol.19 , pp. 4970-4978
    • Pettersson, K.1    Delaunay, F.2    Gustafsson, J.A.3
  • 126
    • 0042702029 scopus 로고    scopus 로고
    • Oestrogen receptor downregulation: An opportunity for extending the window of endocrine therapy in advanced breast cancer
    • Piccart M, Parker LM & Pritchard KI 2003 Oestrogen receptor downregulation: an opportunity for extending the window of endocrine therapy in advanced breast cancer. Annals of Oncology 14 1017-1025.
    • (2003) Annals of Oncology , vol.14 , pp. 1017-1025
    • Piccart, M.1    Parker, L.M.2    Pritchard, K.I.3
  • 129
    • 0030922247 scopus 로고    scopus 로고
    • Repression of interleukin-6 gene expression by 17 beta-estradiol: Inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor
    • Ray P, Ghosh SK, Zhang DH & Ray A 1997 Repression of interleukin-6 gene expression by 17 beta-estradiol: inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor. FEBS Letters 409 79-85.
    • (1997) FEBS Letters , vol.409 , pp. 79-85
    • Ray, P.1    Ghosh, S.K.2    Zhang, D.H.3    Ray, A.4
  • 131
  • 133
    • 0038683988 scopus 로고    scopus 로고
    • Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: A prospective combined analysis of two multicenter trials
    • Robertson JF, Osborne CK, Howell A, Jones SE, Mauriac L, Ellis M, Kleeberg UR, Come SE, Vergote I, Gertler S et al. 2003b Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: a prospective combined analysis of two multicenter trials. Cancer 98 229-238.
    • (2003) Cancer , vol.98 , pp. 229-238
    • Robertson, J.F.1    Osborne, C.K.2    Howell, A.3    Jones, S.E.4    Mauriac, L.5    Ellis, M.6    Kleeberg, U.R.7    Come, S.E.8    Vergote, I.9    Gertler, S.10
  • 134
    • 0033919595 scopus 로고    scopus 로고
    • DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
    • Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL & Wolffe AP 2000 DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nature Genetics 25 338-342.
    • (2000) Nature Genetics , vol.25 , pp. 338-342
    • Robertson, K.D.1    Ait-Si-Ali, S.2    Yokochi, T.3    Wade, P.A.4    Jones, P.L.5    Wolffe, A.P.6
  • 136
    • 0033945861 scopus 로고    scopus 로고
    • DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
    • Rountree MR, Bachman KE & Baylin SB 2000 DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nature Genetics 25 269-277.
    • (2000) Nature Genetics , vol.25 , pp. 269-277
    • Rountree, M.R.1    Bachman, K.E.2    Baylin, S.B.3
  • 139
    • 0035228654 scopus 로고    scopus 로고
    • Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions
    • Safe S 2001 Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions. Vitamins and Hormones 62 231-252.
    • (2001) Vitamins and Hormones , vol.62 , pp. 231-252
    • Safe, S.1
  • 141
    • 0038613843 scopus 로고    scopus 로고
    • Adaptive hypersensitivity to estrogen: Mechanism for superiority of aromatase inhibitors over selective estrogen receptor modulators for breast cancer treatment and prevention
    • Santen RJ, Song RX, Zhang Z, Kumar R, Jeng MH, Masamura S, Yue W & Berstein L 2003 Adaptive hypersensitivity to estrogen: mechanism for superiority of aromatase inhibitors over selective estrogen receptor modulators for breast cancer treatment and prevention. Endocrine-Related Cancer 10 111-130.
    • (2003) Endocrine-Related Cancer , vol.10 , pp. 111-130
    • Santen, R.J.1    Song, R.X.2    Zhang, Z.3    Kumar, R.4    Jeng, M.H.5    Masamura, S.6    Yue, W.7    Berstein, L.8
  • 142
    • 0037237481 scopus 로고    scopus 로고
    • Breast cancer endocrine resistance: How growth factor signaling and estrogen receptor coregulators modulate response
    • Schiff R, Massarweh S, Shou J & Osborne CK 2003 Breast cancer endocrine resistance: how growth factor signaling and estrogen receptor coregulators modulate response. Clinical Cancer Research 9 447-454S.
    • (2003) Clinical Cancer Research , vol.9
    • Schiff, R.1    Massarweh, S.2    Shou, J.3    Osborne, C.K.4
  • 143
    • 9144256614 scopus 로고    scopus 로고
    • Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance
    • Schiff R, Massarweh S, Shou J, Bharwani L, Mohsin SK & Osborne CK 2004 Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance. Clinical Cancer Research 10 331-336S.
    • (2004) Clinical Cancer Research , vol.10
    • Schiff, R.1    Massarweh, S.2    Shou, J.3    Bharwani, L.4    Mohsin, S.K.5    Osborne, C.K.6
  • 144
    • 0032446607 scopus 로고    scopus 로고
    • The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
    • Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA & Greene GL 1998 The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95 927-937.
    • (1998) Cell , vol.95 , pp. 927-937
    • Shiau, A.K.1    Barstad, D.2    Loria, P.M.3    Cheng, L.4    Kushner, P.J.5    Agard, D.A.6    Greene, G.L.7
  • 148
    • 1242341918 scopus 로고    scopus 로고
    • The role of She and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane
    • Song RX, Barnes CJ, Zhang Z, Bao Y, Kumar R & Santen RJ 2004 The role of She and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane. PNAS 101 2076-2081.
    • (2004) PNAS , vol.101 , pp. 2076-2081
    • Song, R.X.1    Barnes, C.J.2    Zhang, Z.3    Bao, Y.4    Kumar, R.5    Santen, R.J.6
  • 149
    • 0033231027 scopus 로고    scopus 로고
    • Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients
    • Speirs V, Malone C, Walton DS, Kerin MJ & Atkin SL 1999 Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients. Cancer Research 59 5421-5424.
    • (1999) Cancer Research , vol.59 , pp. 5421-5424
    • Speirs, V.1    Malone, C.2    Walton, D.S.3    Kerin, M.J.4    Atkin, S.L.5
  • 150
    • 0034487507 scopus 로고    scopus 로고
    • ErbB2 status and the benefit from two or five years of adjuvant tamoxifen in postmenopausal early stage breast cancer
    • Stal O, Borg A, Ferno M, Kallstrom AC, Malmstrom P & Nordenskjold B; South Sweden Breast Cancer Group. Southeast Sweden Breast Cancer Group 2000 ErbB2 status and the benefit from two or five years of adjuvant tamoxifen in postmenopausal early stage breast cancer. Annals of Oncology 11 1545-1550.
    • (2000) Annals of Oncology , vol.11 , pp. 1545-1550
    • Stal, O.1    Borg, A.2    Ferno, M.3    Kallstrom, A.C.4    Malmstrom, P.5    Nordenskjold, B.6
  • 152
    • 0030938647 scopus 로고    scopus 로고
    • The role of transforming growth factor-beta in regulation of estrogen receptor expression in the MCF-7 breast cancer cell line
    • Stoica A, Saceda M, Fakhro A, Salomon HB, Fenster BD & Martin MB 1997 The role of transforming growth factor-beta in regulation of estrogen receptor expression in the MCF-7 breast cancer cell line. Endocrinology 138 1498-1505.
    • (1997) Endocrinology , vol.138 , pp. 1498-1505
    • Stoica, A.1    Saceda, M.2    Fakhro, A.3    Salomon, H.B.4    Fenster, B.D.5    Martin, M.B.6
  • 155
    • 15544389067 scopus 로고    scopus 로고
    • Advances in adjuvant hormonal therapy for postmenopausal women
    • Strasser-Weippl K & Goss E 2005 Advances in adjuvant hormonal therapy for postmenopausal women. Journal of Clinical Oncology 23 1751-1759.
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 1751-1759
    • Strasser-Weippl, K.1    Goss, E.2
  • 156
    • 0035881568 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K
    • Sun M, Paciga JE, Feldman RI, Yuan Z, Coppola D, Lu YY, Shelley SA, Nicosia SV & Cheng JQ 2001 Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K. Cancer Research 61 5985-5991.
    • (2001) Cancer Research , vol.61 , pp. 5985-5991
    • Sun, M.1    Paciga, J.E.2    Feldman, R.I.3    Yuan, Z.4    Coppola, D.5    Lu, Y.Y.6    Shelley, S.A.7    Nicosia, S.V.8    Cheng, J.Q.9
  • 157
    • 0029666144 scopus 로고    scopus 로고
    • Involvment of heregulin-beta2 in the acquisition of the hormone-independent phenotype of breast cancer cells
    • Tang CK, Perez C, Grunt T, Waibel C, Cho C & Lupu R 1996 Involvment of heregulin-beta2 in the acquisition of the hormone-independent phenotype of breast cancer cells. Cancer Research 56 3350-3358.
    • (1996) Cancer Research , vol.56 , pp. 3350-3358
    • Tang, C.K.1    Perez, C.2    Grunt, T.3    Waibel, C.4    Cho, C.5    Lupu, R.6
  • 159
    • 84995870933 scopus 로고
    • Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions
    • Tzukerman MT, Esty A, Santiso-Mere D, Danielian P, Parker MG, Stein RB, Pike JW & McDonnell DP 1994 Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Molecular Endocrinology 8 21-30.
    • (1994) Molecular Endocrinology , vol.8 , pp. 21-30
    • Tzukerman, M.T.1    Esty, A.2    Santiso-Mere, D.3    Danielian, P.4    Parker, M.G.5    Stein, R.B.6    Pike, J.W.7    McDonnell, D.P.8
  • 160
    • 0025077072 scopus 로고
    • Over-expression of the epidermal growth factor receptor in human breast cancer cells fails to induce an estrogen-independent phenotype
    • Valverius EM, Velu T, Shankar V, Ciardiello F, Kim N & Salomon DS 1990 Over-expression of the epidermal growth factor receptor in human breast cancer cells fails to induce an estrogen-independent phenotype. International Journal of Cancer 46 712-718.
    • (1990) International Journal of Cancer , vol.46 , pp. 712-718
    • Valverius, E.M.1    Velu, T.2    Shankar, V.3    Ciardiello, F.4    Kim, N.5    Salomon, D.S.6
  • 161
    • 0038356602 scopus 로고    scopus 로고
    • Postmenopausal women who progress on fulvestrant ('Faslodex') remain sensitive to further endocrine therapy
    • Vergote I, Robertson JF, Kleeberg U, Burton G, Osborne CK & Mauriac L; Trial 0020 Investigators; Trial 0021 Investigators 2003 Postmenopausal women who progress on fulvestrant ('Faslodex') remain sensitive to further endocrine therapy. Breast Cancer Research and Treatment 79 207-211.
    • (2003) Breast Cancer Research and Treatment , vol.79 , pp. 207-211
    • Vergote, I.1    Robertson, J.F.2    Kleeberg, U.3    Burton, G.4    Osborne, C.K.5    Mauriac, L.6
  • 163
    • 0027295315 scopus 로고
    • Transcriptional control of estrogen receptor in estrogen receptor-negative breast carcinoma
    • Weigel RJ & deConinck EC 1993 Transcriptional control of estrogen receptor in estrogen receptor-negative breast carcinoma. Cancer Research 53 3472-3474.
    • (1993) Cancer Research , vol.53 , pp. 3472-3474
    • Weigel, R.J.1    DeConinck, E.C.2
  • 164
    • 0037069418 scopus 로고    scopus 로고
    • Estrogen receptor-interacting protein that modulates its nongenimic activity-crosstalk with Src/Erk phosphorylation cascade
    • Wong CW, McNally C, Nickbarg E, Komm BS & Cheskis BJ 2002 Estrogen receptor-interacting protein that modulates its nongenimic activity-crosstalk with Src/Erk phosphorylation cascade. PNAS 99 14783-14788.
    • (2002) PNAS , vol.99 , pp. 14783-14788
    • Wong, C.W.1    McNally, C.2    Nickbarg, E.3    Komm, B.S.4    Cheskis, B.J.5
  • 165
    • 1842852562 scopus 로고    scopus 로고
    • A phase II trial of letrozole and trastuzumab for ER and/or PgR and HER2 positive metastatic breast cancer
    • Wong ZW, Isaacs C, Harris L & Ellis MJ 2003 A phase II trial of letrozole and trastuzumab for ER and/or PgR and HER2 positive metastatic breast cancer. Breast Cancer Research and Treatment 82 S106.
    • (2003) Breast Cancer Research and Treatment , vol.82
    • Wong, Z.W.1    Isaacs, C.2    Harris, L.3    Ellis, M.J.4
  • 168
    • 0035477320 scopus 로고    scopus 로고
    • Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells
    • Yang X, Phillips DL, Ferguson AT, Nelson WG, Herman JG & Davidson NE 2001 Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. Cancer Research 61 7025-7029.
    • (2001) Cancer Research , vol.61 , pp. 7025-7029
    • Yang, X.1    Phillips, D.L.2    Ferguson, A.T.3    Nelson, W.G.4    Herman, J.G.5    Davidson, N.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.