Pain research update from a genetic point of view

Pain Practice

Volumn 5, Issue 4, 2005, Pages 341-348

  Šerý, Omar ^a,b   Hrazdilová, Olga ^a   Matalová, Eva ^c   Ševčík, Pavel ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

Author keywords

Gene; Gene therapy; Molecular biology; Pain; Polymorphism

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MORPHINE; PROENKEPHALIN; SMALL INTERFERING RNA; VIRUS VECTOR;

ALLODYNIA; ANHIDROSIS; CHRONIC PAIN; CONGENITAL ANALGESIA; DNA MODIFICATION; DNA POLYMORPHISM; EMOTION; FAMILIAL HEMIPLEGIC MIGRAINE; GENE EXPRESSION; GENE THERAPY; GENETIC ASSOCIATION; GENETIC VARIABILITY; HERPES SIMPLEX VIRUS 1; HUMAN; MENTAL DISEASE; NOCICEPTION; NONHUMAN; PAIN ASSESSMENT; RESEARCH ETHICS; REVIEW; SENSORY NERVE CELL;

EID: 29144457594     PISSN: 15307085     EISSN: 15332500     Source Type: Journal    
DOI: 10.1111/j.1533-2500.2005.00036.x     Document Type: Review

References (40)

1. Šerý O, Hladilová R, Novotný M, Hříbková H, Znojil V, Zvolský P. Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism. Acta Neuropsychiatrica. 2003;15:257-261.
2. Blumensohn R, Ringler D, Eli I. Pain perception in patients with schizophrenia. J Nerv Ment Dis. 2002;190:481-483.
3. Lautenbacher S, Krieg JC. Pain perception in psychiatric disorders: a review of the literature. J Psychiatr Res. 1994;28:109-122.
4. Fitzgerald M. The development of nociceptive circuits. Nat Rev Neurosci. 2005;6:507-520.
5. Eli I, Bar-Tal Y, Fuss Z, Korff E. Effect of biological sex differences on the perception of acute pain stimulation in the dental setting. Pain Res Manage. 1996;1:201-205.
6. Zhao X, Liu J, Guan R, Shen Y, Xu P, Xu J. Estrogen affects BDNF expression following chronic constriction nerve injury. Neuroreport. 2003;14:1627-1631.
7. Indo Y, Tsuruta M, Hayashida Y, et al. Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nat Genet. 1996; 13:485-488.
8. Indo Y. Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. Hum Mutat. 2001;18:462-471.
9. Molliver DC, Lindsay J, Albers KM, Davis BM. Overexpression of NGF or GDNF alters transcriptional plasticity evoked by inflammation. Pain. 2005;113:277-284.
10. 2+ channel gene CACNL1A4. Cell. 1996;87:543-552.
11. Spadaro M, Ursu S, Lehmann-Horn F, et al. A G301R Na+/K+ -ATPase mutation causes familial hemiplegic migraine type 2 with cerebellar signs. Neurogenetics. 2004; 5:177-185.
12. Wessman M, Kaunisto MA, Kallela M, Palotie A. The molecular genetics of migraine. Ann Med. 2004;36:462-473.
13. Belfer I, Wu T, Kingman A, Krishnaraju RK, Goldman D, Max MB. Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size. Anesthesiology. 2004;100:1562-1572.
14. Kotlinska J, Rafalski P. Nociceptin/orphanin FQ (N/ OFQ) - the opioid, antiopioid or neuromodulator? Postepy Hig Med Dosw. 2004;58:209-215.
15. Ma F, Xie H, Dong ZQ, Wang YQ, Wu GC. Effect of intrathecal nocistatin on nociceptin/orphanin FQ analgesia in chronic constriction injury rat. Brain Res. 2003;988:189-192.
16. Chen LX, Wang ZZ, Wu H, Fang Q, Chen Y, Wang R. Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice. Neurosci Lett. 2002;331:95-98.
17. Pezet S, Malcangio M, McMahon SB. BDNF: a neuromodulator in nociceptive pathways? Brain Res Rev. 2002;40:240-249.
18. Svensson P, Cairns BE, Wang K, Arendt-Nielsen L. Injection of nerve growth factor into human masseter muscle evokes long-lasting mechanical allodynia and hyperalgesia. Pain. 2003;104:241-247.
19. Szabo I, Wetzel MA, Zhang N, et al. Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization. J Leukoc Biol. 2003;74:1074-1082.
20. Bianchi M, Maggi R, Pimpinelli F, et al. Presence of a reduced opioid response in interleukin-6 knock out mice. Eur J Neurosci. 1999;11:1501-1507.
21. Obreja O, Schmelz M, Poole S, Kress M. Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo. Pain. 2002;96:57-62.
22. Klepstad P, Rakvag TT, Kaasa S, et al. The 118 A > G polymorphism in the human micro-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand. 2004; 48:1232-1239.
23. Kim H, Neubert JK, San Miguel A, et al. Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain. 2004;109:488-496.
24. Solovieva S, Leino-Arjas P, Saarela J, Luoma K, Raininko R, Riihimaki H. Possible association of interleukin 1 gene locus polymorphisms with low back pain. Pain. 2004;109:8-19.
25. Hühne K, Leis S, Schmelz M, Rautenstrauss B, Birklein F. A polymorphic locus in the intron 16 of the human angiotensin-converting enzyme (ACE) gene is not correlated with complex regional pain syndrome I (CRPS I). Eur J Pain. 2004;8:221-225.
26. Compton P, Geschwind DH, Alarcon M. Association between human mu-opioid receptor gene polymorphism, pain tolerance, and opioid addiction. Am J Med Genet. 2003; 121B:76-82.
27. Myers KJ, Dean NM. Sensible use of antisense: how to use oligonucleotides as research tools. Trends Pharmacol Sci. 2000;21:19-23.
28. Chuang IC, Jhao CM, Yang CH, et al. Intramuscular electroporation with the pro-opiomelanocortin gene in rat adjuvant arthritis. Arthritis Res Ther. 2004;6:R7-R14.
29. Glykys J, Guadama M, Marcano L, Ochoa E, Eblen-Zajjur A. Inflammation induced increase of fluoride resistant acid phosphatase (FRAP) activity in the spinal dorsal horn in rats. Neurosci Lett. 2003;337:167-169.
30. Honda T, Yokota S, Gang FG, Takahashi M, Sugiura Y. Evidence for the c-ret protooncogene product (c-Ret) expression in the spinal tanycytes of adult rat. J Chem Neuroanat. 1999;17:163-168.
31. Wilson SP, Yeomans DC, Bender MA, Lu Y, Goins WF, Glorioso JC. Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus. Proc Natl Acad Sci USA. 1999;96:3211-2316.
32. Wilson SP, Yeomans DC. Virally mediated delivery of enkephalin and other neuropeptide transgenes in experimental pain models. Ann NY Acad Sci. 2002;971:515-521.
33. Braz J, Beaufour C, Coutaux A, et al. Therapeutic efficacy in experimental polyarthritis of viral-driven enkephalin overproduction in sensory neurons. J Neurosci. 2001; 21:7881-7888.
34. Hahm ET, Lee JJ, Min BI, Cho YW. Opioid inhibition of GABAergic neurotransmission in mechanically isolated rat periaqueductal gray neurons. Neurosci Res. 2004;50:343-354.
35. Xu Y, Gu Y, Xu GY, Wu P, Li GW, Huang LY. Adeno-associated viral transfer of opioid receptor gene to primary sensory neurons: a strategy to increase opioid anti-nociception. Proc Natl Acad Sci USA. 2003;100:6204-6209.
36. Eaton MJ, Blits B, Ruitenberg MJ, Verhaagen J, Oudega M. Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord. Gene Ther. 2002;9:1387-1395.
37. Hao S, Mata M, Wolfe D, Huang S, Glorioso JC, Fink DJ. HSV-mediated gene transfer of the glial cell-derived neurotrophic factor provides an antiallodynic effect on neuropathic pain. Mol Ther. 2003;8:367-375.
38. Kang W, Wilson MA, Bender MA, Glorioso JC, Wilson SP. Herpes virus-mediated preproenkephalin gene transfer to the amygdala is antinociceptive. Brain Res Rev. 1998;792:133-135.
39. Lee IO, Yukhananov R, Standaert DG, Crosby G. NMDA-R1 antisense oligodeoxynucleotides modify formalininduced nociception and spinal c-Fos expression in rat spinal cord. Pharmacol Biochem Behav. 2004;79:183-188.
40. Tan PH, Yang LC, Shih HC, Lan KC, Cheng JT. Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat. Gene Ther. 2005;12:59-66.