Increased glutathione conjugate transport: A possible compensatory protection mechanism against oxidative stress in obesity?

International Journal of Obesity

Volumn 30, Issue 1, 2006, Pages 134-140

  Ozaydin, A ^a   Onaran, I ^a   Yesim T E ^b   Sargin, H ^c   Avsar K ^d   Sultuybek, G ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b HASEKI EDUCATION AND RESEARCH HOSPITAL   (Turkey)

^c DR LUTFI KIRDAR KARTAL EDUCATION AND RESEARCH HOSPITAL   (Turkey)

^d GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Erythrocyte; Glutathione S conjugate transport; Oxidative stress

Indexed keywords

GLUTATHIONE; GLUTATHIONE TRANSFERASE; MALONALDEHYDE;

ADULT; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; DISEASE PREDISPOSITION; ERYTHROCYTE; FEMALE; HEMOLYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMBRANE TRANSPORT; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ADULT; BIOLOGICAL TRANSPORT; CELLS, CULTURED; DINITROCHLOROBENZENE; ERYTHROCYTES; FEMALE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEMOLYSIS; HUMANS; MALE; MALONDIALDEHYDE; MIDDLE AGED; OBESITY; OXIDATIVE STRESS;

EID: 29044446050     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0803108     Document Type: Article

References (50)

1. Kirkland DJ, Muller L. Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds. Mutat Res 2000; 464: 37-147.
2. Pratt IS, Barron T. Regulatory recognition of indirect genotoxicity mechanisms in the European Union. Toxicol Lett 2003; 140-141: 53-62.
3. Asayama K, Nakane T, Dobashi K, Kodera K, Hayashibe H, Uchida N et al. Effect of obesity and troglitazone on expression of two glutathione peroxidases: cellular and extracellular types in serum, kidney and adipose tissue. Free Radic Res 2001; 34: 337-347.
4. Carmiel-Haggai M, Cederbaum AI, Nieto N. Binge ethanol exposure increases liver injury in obese rats. Gastroenterology 2003; 125: 1818-1833.
5. Roe AL, Howard G, Blouin R, Snawder JE. Characterization of cytochrome P450 and glutathione S-transferase activity and expression in male and female ob/ob mice. Int J Obes Relat Metab Disord 1999; 23: 48-53.
6. Watson AM, Poloyac SM, Howard G, Blouin RA. Effect of leptin on cytochrome P-450, conjugation, and antioxidant enzymes in the ob/ob mouse. Drug Metab Dispos 1999; 27: 695-700.
7. Faber P, Johnstone AM, Gibney ER, Elia M, Stubbs RJ, Duthie GG et al. The effect of rate of weight loss on erythrocyte glutathione concentration and synthesis in healthy obese men. Clin Sci 2002; 102: 569-577.
8. Cazzola R, Rondanelli M, Russo-Volpe S, Ferrari E, Cestaro B. Decreased membrane fluidity and altered susceptibility to peroxidation and lipid composition in overweight and obese female erythrocytes. J Lipid Res 2004; 45: 1846-1851.
9. Sharma R, Awasthi S, Zimniak P, Awasthi YC. Transport of glutathione-conjugates in human erythrocytes. Acta Biochim Pol 2000; 47: 751-762.
10. Pickett CB, Lu AYH. Glutathione S-transferases: gene structure, regulation, and biological function. Ann Rev Biochem 1989; 58: 743-764.
11. Awasthi S, Srivastava SK, Ahmad F, Ahmad H, Ansari GA. Interaction of glutathione S-transferase with ethacrynic acid and its glutathione conjugate. Biochim Biophys Acta 1993; 1164: 173-178.
12. Bilzer M, Krauth-Siegel RL, Schirmer RIJ, Akerboom TP, Sies JJ, Schulz GE. Protein structure interaction of a glutathione S-conjugate with glutathione reductase. Kinetic and X-ray crystallographic studies. Eur J Biochemistry 1984; 138: 373-378.
13. Board PG. Transport of glutathione S-conjugates from human erythrocytes. FEBS Lett 1981; 124: 163-165.
14. La Belle EF, Singh SV, Srivastava SK, Awasthi YC. Evidence for different transport systems for oxidized glutathione and S-dinitrophenyl glutathione in human erythrocytes. Biochim Biophys Acta 1986; 139: 538-544.
15. Awasthi YC, Misra G, Rassinand DK, Srivastava SK. Detoxification of xenobiotics of glutathione S-transferases in erythrocytes: the transport of the conjugate of glutathione and 1-choloro-2,4-dinitrobenzene. Br J Haematol 1983; 55: 419-425.
16. 2-dependent cardiac transport system for glutathione S-conjugates. J Biol Chem 1989; 264: 17343-17348.
17. Grune T, Siems W, Kowalewski J, Zollner H, Esterbauer H. Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by enterocytes of rat small intestine. Biochem Int 1991; 25: 963-971.
18. Akerboom TPM, Bartosz G, Sies H. Low and high-Km transport of dinitrophenyl glutathione in inside out vesicles from human erythrocytes. Biochim Biophys Acta 1992; 1103: 115-119.
19. Barnett CR, Abbott RA, Bailey CJ, Flatt PR, Ioannides C. Cytochrome P-450-dependent mixed-function oxidase and glutathione S-transferase activities in spontaneous obesity-diabetes. Biochem Pharmacol 1992; 43: 1868-1871.
20. Beltowski J, Wojcicka G, Gorny D, Marciniak A. The effect of dietary-induced obesity on lipid oxidation, antioxidant enzymes and total plasma antioxidant capacity. J Physiol Pharmacol 2000; 51: 883-896.
21. Prohaska JR, Wittmers LE, Haller Jr EW. Influence of genetic obesity, food intake and adrenalectomy in mice on selected trace element-dependent protective enzymes. J Nutr 1988; 118: 739-746.
22. York JL, Wolff GL. Glutathione S-transferase activity and isoenzyme concentrations in obese Avy/a and lean a/a mice. Proc Soc Exp Biol Med 1994; 205: 186-189.
23. Preventing and managing the global epidemic of obesity: report of a WHO Consultation on Obesity. WHO/NUT/NCD98.1, Geneva, 1998.
24. Onaran I, Yalcin AS, Sultuybek G. Effect of donor age on the susceptibility of erythrocytes and erythrocyte membranes to cumene hydroperoxide-induced oxidative stress. Mech Ageing Dev 1997; 98: 127-138.
25. Beutler E (ed.). Red cell metabolism. In: A Manual of Biochemical Methods 3rd edn. Grune and Stratton: New York, 1984, pp. 8-19.
26. Habig WH, Pabs MJ, Jacobs WB. Glutathione S-transferases. J Biol Chem 1974; 279: 7130-7139.
27. Lin X, Zhang F, Bradbury CM, Kaushal A, Li L, Spitz DR et al. 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Cancer Res 2003; 63: 3413-3417.
28. Shen HM, Ding WX, Ong CN. Intracellular glutathione is a cofactor in methylseleninic acid-induced apoptotic cell death of human hepatoma HEPG(2) cells. Free Radic Biol Med 2002; 33: 552-561.
29. Borenshtein D, Ofri R, Werman M, Stark A, Tritschler HJ, Moeller W et al. Cataract development in diabetic sand rats treated with alpha-lipoic acid and its gamma-linolenic acid conjugate. Diabetes Metab Res Rev 2001; 17: 44-50.
30. Langley-Evans SC, Phillips GJ, Jackson AA. Fetal exposure to low protein maternal diet alters the susceptibility of young adult rats to sulfur dioxide-induced lung injury. J Nutr 1997; 127: 202-209.
31. Velthuis-Te Wierik LJ, Van Den Berg H, Weststrate JA, Van Het Hof KH, de Graaf C. Consumption of reduced-fat products: effects on parameters of anti-oxidative capacity. Eur J Clin Nutr 1996; 50: 214-219.
32. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr 2004; 134: 489-492.
33. Yoshida K, Hirokawa J, Tagami S, Kawakami Y, Urata Y, Kondo T. Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux. Diabetologia 1995; 8: 201-210.
34. Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol 1997; 82: 291-295.
35. Awasthi YC, Garg HS, Dao DD, Partridge CA, Srivastava SK. Enzymatic conjugation of erythrocyte glutathione with 1-chloro-2,4-dinitrobenzene: the fate of glutathione conjugate in erythrocytes and the effect of glutathione depletion on hemoglobin. Blood 1981; 58: 733-738.
36. Cazzola R, Rondanelli M, Russo-Volpe S, Ferrari L, Cestaro B. Decreased membrane fluidity and altered susceptibility to peroxidation and lipid composition in over-weight and obese female erythrocytes. J Lipid Res 2004; 45: 1846-1851.
37. Fabris R, Mingrone G, Milan G, Manco M, Granzotto M, Dalla Pozza A et al. Further lowering of muscle lipid oxidative capacity in obese subjects after biliopancreatic diversion. J Clin Endocrinol Metab 2004; 89: 1753-1759.
38. Ozata M, Mergen M, Oktenli C, Aydin A, Sanisoglu SY, Bolu E et al. Increased oxidative stress and hypozincemia in male obesity. Clin Biochem 2002; 35: 627-631.
39. Vincent HK, Powers SK, Stewart DJ, Shanely RA, Demirel H, Naito H. Obesity is associated with increased myocardial oxidative stress. Int J Obes Relat Metab Disord 1999; 23: 67-74.
40. Sattler W, Malle E, Kostner GM. Methodological approaches for assessing lipid and protein oxidation and modification in plasma and isolated lipoproteins. Methods Mol Biol 1998; 110: 67-191.
41. 35S] glutathione photoaffinity labeling of rat liver plasma membrane-associated proteins. Biochim Biophys Acta 1989; 982: 15-23.
42. Lindquist RN, Lynn Jr JL, Lienhard GE. Possible transition-state analogs for ribonuclease. The complexes of uridine with oxovanadium(IV) ion and vanadium(V) ion. J Am Chem Soc 1973; 95: 8762-8768.
43. Onaran I, Ozaydin A, Gultepe M, Sultuybek G. Transport of glutathione conjugate in erythrocytes from aged subjects and susceptibility to oxidative stress following inhibition of the glutathione S-conjugate pump. Mech Ageing Dev 1998; 103: 195-207.
44. Weiss DJ. Susceptibility of canine, feline and human erythrocytes to oxidant-mediated injury. Vet Clin Pathol 1988; 17: 75-78.
45. Tavazzi B, Di Pierro D, Amorini AM, Fazzina G, Tuttobene M, Giardina B et al. Energy metabolism and lipid peroxidation of human erythrocytes as a function of increased oxidative stress. Eur J Biochem 2000; 267: 684-689.
46. Zou CG, Agar NS, Jones GE. Chlorodinitrobenzene-mediated damage in the human erythrocyte membrane leads to hemolysis. Life Sci 2002; 1: 35-746.
47. Beguinot F, Tramontano D, Duilio C, Formisano S, Beguinot E, Mattioli P et al. Alteration of erythrocyte membrane lipid fluidity in human obesity. J Clin Endocrinol Metab 1985; 60: 1226-1230.
48. Daly SE, Inch RW, Tustanoff ER. Amino acid transport in multidrug-resistant Chinese hamster ovary cells. Biochem Int 1992; 27: 301-310.
49. Hofmann M, Mainka P, Tritschler H, Fuchs J, Zimmer G. Decrease of red cell membrane fluidity and -SH groups due to hyperglycemic conditions is counteracted by alpha-lipoic acid. Arch Biochem Biophys 1995; 324: 85-92.
50. Al-Makdissy N, Younsi M, Pierre S, Ziegler O, Donner M. Sphingomyelin/cholesterol ratio: an important determinant of glucose transport mediated by GLUT-1 in 3T3-E1 preadipocytes. Cell Signal 2003; 5: 1019-1030.