Intracellular glutathione is a cofactor in methylseleninic acid-induced apoptotic cell death of human hepatoma HEPG2 cells

Free Radical Biology and Medicine

Volumn 33, Issue 4, 2002, Pages 552-561

  Shen, Han Ming ^a   Ding, Wen Xing ^a   Ong, Choon Nam ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Apoptosis; Free radicals; Glutathione; HepG2; Methylseleninic acid; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; DNA FRAGMENT; GLUTATHIONE; METHYLSELENINIC ACID; SELENIUM DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; METHYLSELENIC ACID; ORGANOSELENIUM DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL LEVEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG METABOLISM; GLUTATHIONE METABOLISM; HEPATOMA CELL; HUMAN; HUMAN CELL; NICK END LABELING; PRIORITY JOURNAL; BIOLOGICAL MODEL; CELL CULTURE; CELL MEMBRANE POTENTIAL; CHEMOLUMINESCENCE; INTRACELLULAR MEMBRANE; LIVER CELL CARCINOMA; LIVER MITOCHONDRION; LIVER TUMOR; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY;

ANTICARCINOGENIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CHEMILUMINESCENCE; GLUTATHIONE; HUMAN; INTRACELLULAR MEMBRANES; LIVER NEOPLASMS; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; MODELS, BIOLOGICAL; ORGANOSELENIUM COMPOUNDS; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED; CHEMILUMINESCENT MEASUREMENTS; HUMANS;

EID: 0037101888     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00918-8     Document Type: Article

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