Malignancy-induced autoimmunity to MUC1: Initial antibody characterization

Journal of Peptide Research

Volumn 66, Issue 6, 2005, Pages 357-363

  Graves, C R L ^a   Robertson, J F R ^a   Murray, A ^b   Price, M R ^a   Chapman, C J ^a,c  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Oncimmune Germany GmbH   (United Kingdom)

^c NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

Autoantibodies; Breast cancer; Cancer; MUC1; Mucin; Myosarcoma; Peptides

Indexed keywords

ANTIBODY; AUTOANTIBODY; EPITOPE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MUCIN 1; PEPTIDE;

AFFINITY CHROMATOGRAPHY; ANTIBODY ISOLATION; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; BREAST CANCER; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; MOLECULE; MYOSARCOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN PURIFICATION; SERUM; TUMOR IMMUNITY;

ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOIMMUNITY; BREAST NEOPLASMS; CA-15-3 ANTIGEN; HUMANS; MYOSARCOMA; PEPTIDE FRAGMENTS;

EID: 28944447243     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.2005.00297.x     Document Type: Article

References (30)

1. Taylor-Papadimitriou, J., Burchell, J., Miles, D.W. & Dalziel, M. (1999) MUC1 and cancer. Biochim. Biophys. Acta 1455, 301-313.
2. Miles, D.W. & Taylor-Papadimitriou, J. (1999) Therapeutic aspects of polymorphic epithelial mucin in adenocarcinoma. Pharmacol. Ther. 82, 97-106.
3. von Mensdorff-Pouilly, S., Snijdewint, F.G., Verstraeten, A.A., Verheijen, R.H. & Kenemans, P. (2000) Human MUC1 mucin: a multifaceted glycoprotein. Int. J. Biol. Markers 15, 343-356.
4. Zotter, S., Hageman, P.C., Lossnitzer, A., Moori, W.J. &. Hilgers, J. (1988) Tissue and tumor distribution of human polymorphic epithelial mucin. Cancer Rev. 11/12, 55-101.
5. Heyderman, E., Steele, K. & Ormerod, M.G. (1979) A new antigen on the epithelial membrane: its immunoperoxidase localisation in normal and neoplastic tissue. J. Clin. Pathol. 32, 35-39.
6. Robertson, J.F.R., Jaeger, W., Syzmendera, J.J., Selby, C., Coleman, R., Howell, A., Winstanley, J., Jonssen, P.E., Bombardieri, E., Sainsbury, J.R.C., Gronberg, H., Kumpulainen, E., Blamey, R.W. on behalf of the European Group for Serum Tumor Markers in Breast Cancer (1999) The objective measurement of remission and progression in metastatic breast cancer by use of serum tumor markers. Eur. J. Cancer 35, 47-53.
7. Bieche, I. & Lidereau, R. (1997) A gene dosage effect is responsible for high overexpression of the MUC1 gene observed in human breast tumors. Cancer Genet. Cytogenet. 98, 75-80.
8. Zaretsky, J., Sarid, R., Aylon, Y., Mittelman, L.A., Wrescher, D.H. & Keydar, I. (1999) Analysis of the promoter of the MUC1 gene overexpressed in breast cancer. FEBS Lett. 461, 189-195.
9. Müller, S., Alving, K., Peter-Katalinics, J., Zachara, N., Gooley, A.A. &. Hanisch, F. (1999) High density O-glycosylation on tandem repeat peptide from secretory MUC1 of T47D breast cancer cells. J. Biol. Chem. 274, 18165-18172.
10. Lloyd, K.O., Burchell, J., Kudryashov, V., Yin, B.W.T. & Taylor-Papadimitriou, J. (1996) Comparison of O-linked carbohydrate chains in MUC1 mucin from normal breast epithelial cell lines and breast carcinoma cell lines. J. Biol Chem. 271, 33325-33334.
11. Müller, S. & Hanisch, F. (2002) Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast cancer mucin. J. Biol. Chem. 277, 26103-26112.
12. Karsten, U., Serttas, N., Paulsen, H., Danielczyk, A. &. Goletz, S. (2004) Binding patterns of DTR-specific antibodies reveal a glycosylation conditioned tumor-specific epitope of the epithelial mucin (MUC1). Glycobiology 14, 681-692.
13. Price, M.R., Rye, P.D., Petrakou, E., Murray, A., Brady, K., Imai, S., Haga, S., Kiyozuka, Y., Schol, D., Meulenbroek, M.F.A., Snijdewint, F.G.M., von Mensdorff-Pouilly, S., Verstraeten, R.A., Kenemans, P., Blockzjil, A., Nilsson, K., Nilsson, O., Reddish, M., Suresh, M.R., Koganty, R.R., Portier, S., Baronic, L., Berg, A., Longenecker, M.B., Hilkens, J., Boer, M., Karanikas, V., McKenzie, I.F.C., Galanina, O.E., Simeoni, L.A., Ter-Grigoryan, A.G., Belyanchikov, I.M., Bovin, N.V., Cao, Y., Karsten, U., Dai, J., Allard, W.J., Davis, G., Yeung, K.K., Hanisch, F-G., Lloyd, K.O., Kudryashov, V., Sikut, R., Sikut, A., Zhang, K., Baeckström, D., Hansson, G.C., Reis, C.A., Hassan, H., Bennet, E.P., Claussen, H., Norum, L., Varaas, T., Kierulf, B., Nustad, K., Ciborowski, P., Konitzki, W.M., Magarian-Blander, J., Finn, O. & Hilgers, J. (1998) Summary report on the ISOBM TD-4 workshop: analysis of 56 monoclonal antibodies against the MUC1 mucin. Tumor Biol. 19 (Suppl 1), 1-20.
14. Bon, G.G., Kenemans, P., van Kamp, G.J., Yedema, C.A. & Hilgers, J. (1990) Review on the clinical value of polymorphic epithelial mucin for the management of carcinoma patients. J. Nucl. Allied Sci. 34, 151-161.
15. Rughetti, A., Turchi, V., Ghetti, C.A., Scambia, G., Panici, P.B., Roncucci, G., Mancuso, S., Frati, L. & Nuti, M. (1993) Human B-cell immune response to the polymorphic epithelial mucin. Cancer Res. 53, 2457-2459.
16. Kotera, Y., Fontenot, J.D., Pecher, G., Metzgar, R.S. & Finn, O.J. (1994) Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res. 54, 2856-2860.
17. von Mensdorff-Pouilly, S., Petrakou, E., Kenemans, P., van Uffelen, K., Verstiaeten, A.A., Snijdewint, F.G., van Kamp, G.J., Schol, DJ., Reis, C.A., Price, M.R., Livingston, P.O. & Hilgers, J. (2000) Reactivity of natural and induced human antibodies to MUC1 mucin with MUC1 peptides and n-acetylgalactosamine (GalNAc) peptides. Int. J. Cancer 86, 702-712.
18. Snijdewint, F.G., von Mensdorff-Pouilly, S., Karuntu-Wanamarta, A.H., Verstraeten, A.A., van Zanten-Przybysz, I., Hummel, P., Nijman, H.W., Kenemans, P. &. Hilgers, J. (1999) Cellular and humoral immune responses to MUC1 mucin and tandem-repeat peptides in ovarian cancer patients and controls. Cancel Immunol. Immunother. 48, 47-55.
19. Grinstead, J.S., Koganty, R.R., Krantz, M.J., Longenecker, B.M. &. Campbell, A.P. (2002) Effect of glycosylation on MUC1 humoral immune recognition: NMR studies of MUC1 glycopeptide-antibody interactions. Biochemistry 41, 9946-9961.
20. Burchell, J., Taylor-Papadimitriou, J., Boshell, M., Gendler, S. & Duhig, T. (1989) A short sequence within the amino acid tandem repeat of a cancer-associated mucin, contains immunodominant epitopes. Int. J. Cancer 44, 691-696.
21. Snijdewint, F.G., von Mensdorff-Pouilly, S., Karuntu-Wanamarta, A.H., Verstraeten, A.A., Livingston, P.O., Hilgers, J. & Kenemans, P. (2001) Antibody-dependent cell-mediated cytotoxicity can be induced by MUC1 peptide vaccination of breast cancer patients. Int. J. Cancer 93, 97-106.
22. Xu, Y., Gendler, S.J. & Franco, A. (2004) Designer glycopeptides for cytotoxic T cell-based elimination of carcinomas. J. Exp. Med. 199, 707-716.
23. O'Sullivan, C., Price, M.R. & Baldwin, R.W. (1990) Polymorphic epithelial mucin from the sera of advanced breast cancer patients - isolation and partial characterisation. Br. J. Cancel 61, 801-808.
24. Price, M.R., Hudecz, F., O'Sullivan, C., Baldwin, R.W., Edwards, P.M. &. Tendler, S.J. (1990) Immunological and structural features of the protein core of human polymorphic epithelial mucin. Mol. Immunol 27, 795-802.
25. Petrakou, E., Murray, A., Rosamund, C., Graves, L. & Price, M.R. (1998) Evaluation of Pepscan analyses for epitope mapping of anti-MUC1 monoclonal antibodies - a comparative study and review of five antibodies. Anticancer Res. 18, 4419-4421.
26. Dalziel, M., Whitehouse, C., McFarlane, I., Brockhausen, I., Gschmeissner, S., Schwientek, T., Clausen, H., Burchell, J.M. & Taylor-Papadimitriou, J. (2001) The relative activities of the C2GnT1 and ST3Gal-1 glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1. J. Biol. Chem. 176, 11007-11015.
27. von Mensdorff-Pouilly, S., Snijdewint, F.G., Verstraeten, A.A., Verheijen, R.H. & Kenemans, P. (1996) Human MUC1 mucin: a multifaceted glycoprotein. Int. J. Biol. Markers 15, 343-356.
28. Petrarca, C., Rughetti, A., Rahimi, H., D'Agostini, F., Turchi, V., Ghetti, C.A., Scambia, G., Frati, L. & Nuti, M. (1996) Human antibodies against the polymorphic epithelial mucin in ovarian cancer patients recognise a novel sequence in the tandem repeat region. Eur. J. Cancer 32A, 2155-2163.
29. Kim, S.K., Ragupathi, G., Cappello, S., Kagan, E. &. Livingston, P.O. (2000) Effect of immunological adjuvant combinations on the antibody and T-cell response to vaccination with MUC1-KLH and GD3-KLH conjugates. Vaccine 19, 530-537.
30. Domenech, N., Henderson, R.A. & Finn, O.J. (1995) Identification of an HLA-Au-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin. J. Immunol. 155, 4766-4774.