Cellular and humoral immune responses to MUC1 mucin and tandem-repeat peptides in ovarian cancer patients and controls

Cancer Immunology Immunotherapy

Volumn 48, Issue 1, 1999, Pages 47-55

  Snijdewint, F G M ^a   Von Mensdorff Pouilly, S ^a   Karuntu Wanamarta, A H ^a   Verstraeten, A A ^a   Van Zanten Przybysz, I ^a   Hummel, P ^a   Nijman, H W ^a   Kenemans, P ^a   Hilgers, J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cellular response; Humoral response; Immunotherapy; MUC1; Ovarian cancer

Indexed keywords

MEMBRANE PROTEIN; MUCIN; PEPTIDE;

ARTICLE; CANCER IMMUNOLOGY; CANCER IMMUNOTHERAPY; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MONONUCLEAR CELL; OVARY CANCER; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TANDEM REPEAT;

AMINO ACID SEQUENCE; ANTIBODY FORMATION; CA-15-3 ANTIGEN; CANDIDA ALBICANS; FEMALE; HUMANS; IMMUNITY, CELLULAR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; OVARIAN NEOPLASMS; PREGNANCY; T-LYMPHOCYTES; TANDEM REPEAT SEQUENCES;

EID: 0032918203     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050547     Document Type: Article

References (42)

1. 1. Agrawal B, Reddish MA (1995) Does pregnancy immunize against breast cancer? Cancer Res 55:2257
2. 2. Agrawal B, Krantz MJ, Reddish MA, Longenecker BM (1998) Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2. Nat Med 4:43
3. 3. Apostolopoulos V, Xing PX, McKenzie IFC (1994) Marine response to cells transfected with human MUC1: immunisation with cellular and synthetic antigens. Cancer Res 54:5186
4. 4. Apostolopoulos V, Loveland BE, Pietersz GA, McKenzie IFC (1995) Cytotoxic T lymphocytes in mice immunized against human MUC1 are MHC restricted. J Immunol 155:5089
5. 5. Barnd DL, Lan MS, Metzgar RS, Finn OJ (1989) Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells. Proc Natl Acad Sci USA 86:7159
6. 6. Böhm CM, Mulder MC, Zennadi R, Notter M, Schmitt-Gräff A, Finn OJ, Taylor-Papadimitriou J, Stein H, Clausen H, Riecken O, Hanski C (1997) Carbohydrate recognition on MUC1-expressing targets enhances cytotoxicity of a T cell subpopulation. Scand J Immunol 46:27
7. 7. Bon GG, Verheijen RHM, Zuetenhorst JM, Kamp GJ van, Verstraeten AA, Kenemans P (1996) Mucin-like carcinoma-associated antigen serum levels in patients with adenocarcinomas originating from ovary, breast and colon. Gynecol Obstet Inv 42:58
8. 8. Bon GG, Mensdorff-Pouilly S von, Kenemans P, Kamp GJ van, Verstraeten RA, Hilgers J, Meijer S, Vermorken JB (1997) Clinical and technical evaluation of ACS™BR serum assay of MUC1 gene-derived glycoprotein in breast cancer, and comparison with CA 15-3 assays. Clin Chem 43:585
9. 9. Burchell J, Gendler S, Taylor-Papadimitriou J, Girling A, Lewis A, Millis R, Lamport D (1987) Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res 47:5476
10. 10. Coventry BJ, Weeks SC, Heckford SE, Sykes PJ, Bradley J, Skinner JM (1996) Lack of IL-2 cytokine expression despite I1-2 messenger RNA transcription in tumor-infiltrating lymphocytes in primary human breast carcinoma: selective expression of early activation markers. J Immunol 156:3486
11. 11. Domenech N, Henderson RA, Finn OJ (1995) Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin. J Immunol 155:4766
12. 12. Engel LW, Young NA, Tralka TS, Lippman ME, O'Brien SJ, Joyce MJ (1978) Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. Cancer Res 38:3352
13. 13. Gendler S, Taylor-Papadimitriou J, Duhig T, Rothbard J, Burchel J (1988) A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. J Biol Chem 263:12820
14. 14. Gimmi CD, Morrison BW, Mainprice BA, Gribben JG, Boussiotis VA, Freeman GJ, Park SYL, Watanabe M, Gong J, Hayes DF, Kufe DW, Nadler LM (1997) Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells. Nat Med 2:1367
15. 15. Gourevitch MM, Mensdorff-Pouilly S von, Litvinov SV, Kenemans P, Kamp GJ van, Verstraeten AA, Hilgers J (1995) Polymorphic epithelial mucin (MUC-1)-containing circulating immune complexes in carcinoma patients. Br J Cancer 72:934
16. 16. Hanski C, Drechsler K, Hanisch F, Sheehan J, Manske M, Ogorek D, Klussmann E, Hanski M, Blank M, Xing P, McKenzie IFC, Devine PL, Riecken E (1993) Altered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-Lewis(x) expression. Cancer Res 53:4082
17. 17. Hilkens J, Buijs F, Hilgers J, Hageman P, Calafat J, Sonnenberg A, Valk M van der (1984) Monoclonal antibodies against human milk-fat globule membranes detecting differentiation antigens of the mammary gland and its tumors. Int J Cancer 34:197
18. 18. Hilkens J, Ligtenberg MJ, Vos HL, Litvinov SV (1992) Cell membrane-associated mucins and their adhesion-modulating property. Trends Biochem Sci 17:359
19. 19. Hull SR, Bright A, Carraway KL, Abe M, Hayes DF, Kufe DW (1989) Oligosaccharide differences in the DF3 sialomucin antigen from normal human milk and the BT-20 human breast carcinoma cell line. Cancer Commun 1:261
20. 20. Ioannides CG, Freedman RS, Platsoucas CD, Rashed S, Kim YP (1991) Cytotoxic T cell clones isolated from ovarian tumor-infiltrating lymphocytes recognize multiple antigenic epitopes on autologous tumor cells. J Immunol 146:1700
21. 21. Ioannides CG, Fisk B, Jerome KR, Irimura T, Wharton JT, Finn OJ (1993) Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides. J Immunol 151:3693
22. 22. Jaworek D, Zepke D, Hauber R (1992) Technical and clinical evaluation of a new automated CA 15-3 test. In: Klapdor R (ed) Tumor associated antigens, oncogenes, receptors, cytokines in tumor diagnosis and therapy at the beginning of the nineties. Zuckschwerdt, München, pp 259-262
23. 23. Jerome KR, Barnd DL, Bendt KM, Boyer CM, Taylor-Papadimitriou J, McKenzie IFC, Bast RC Jr, Finn OJ (1991) Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells. Cancer Res 51:2908
24. 24. Jerome KR, Domenech N, Finn OJ (1993) Tumor-specific cytotoxic T cell clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin complementary DNA. J Immunol 151:1654
25. 25. Jerome KR, Kirk AD, Pecher G, Ferguson WW, Finn OJ (1997) A survivor of breast cancer with immunity to MUC-1 mucin, and lactational mastitis. Cancer Immunol Immunother 43:355
26. 26. Jurcic JG, Scheinberg DA, Houghton AN (1996) Monoclonal antibody therapy of cancer. Cancer Chemother Biol Response Modif 16:168
27. 27. Kalache A, Maguire A, Thompson SG (1993) Age at last full-term pregnancy and risk of breast cancer. Lancet 341:33
28. 28. Karanikas V, Hwang LA, Pearson J, Ong CS, Apostolopoulos V, Vaughan H, Xing PX, Jamieson G, Pietersz G, Tait B, Broadbent R, Thynne G, McKenzie IFC (1997) Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein. J Clin Invest 100:2783
29. 29. Kotera Y, Fontenot JD, Pecher G, Metzgar RS, Finn OJ (1994) Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res 54:2856
30. 30. Ligtenberg MJ, Vos HL, Gennissen AM, Hilkens J (1990) Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini. J Biol Chem 265:5573
31. 31. Mensdorff-Pouilly S von, Gourevitch MM, Kenemans P, Verstraeten AA, Litvinov SV, van Kamp GJ, Meijer S, Vermorken J, Hilgers J (1996) Humoral immune response to polymorphic epithelial mucin (MUC-1) in patients with benign and malignant breast tumors. Eur J Cancer 32A:1325
32. 32. Mensdorff-Pouilly S von, Gourevitch MM, Kenemans P, Verstraeten AA, Kamp GJ van, Kok A, Uffelen K van, Snijdewint FGM, Paul MA, Meijer S, Hilgers J (1998) An enzyme-linked immunosorbent assay for the measurement of circulating antibodies to polymorphic epithelial mucin (MUC1). Tumor Biol 19:186
33. 33. Nakamori S, Ota DM, Cleary KR, Shirotani K, Irimura T (1994) MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma. Gastroenterology 106:353
34. 34. Regimbald LH, Pilarski LM, Longenecker BM, Reddish MA, Zimmermann G, Hugh JC (1996) The breast mucin MUC1 as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer. Cancer Res 56:4244
35. 35. Riethmuller G, Schneider-Gadicke E, Schlimok G, Schmiegel W, Raab R, Hoffken K, Gruber R, Pichlmaier H, Hirche H, Pichlmayr R (1994) Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German Cancer Aid 17-1A Study Group. Lancet 343:1177
36. 36. Rowse GJ, Tempero RM, Vanlith ML, Hollingsworth MA, Gendler SJ (1998) Tolerance and immunity to MUC1 in a human MUC1 transgenic murine model. Cancer Res 58:315
37. 37. Rughetti A, Turchi V, Apollonj-Ghetti C, Scambia G, Panici PB, Roncucci G, Mancuso S, Frati L, Nuti M (1993) Human B-cell immune response to the polymorphic epithelial mucin. Cancer Res 53:2457
38. 38. Tampellini M, Berruti A, Gerbino A, Buniva T, Torta M, Gorzegno G, Faggiuolo R, Cannone R, Farris A, Destefanis M, Moro G, Deltetto F, Dogliotti L (1997) Relationship between CA 15-3 serum levels and disease extent in predicting overall survival of breast cancer patients with newly diagnosed metastatic disease. Br J Cancer 75:698
39. 39. Wesseling J, Valk SW van der, Hilkens J (1996) A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1. Mol Biol Cell 7:565
40. 40. Yedema C, Massuger L, Hilgers J, Servaas J, Poels L, Thomas C, Kenemans P (1988) Pre-operative discrimination between benign and malignant ovarian tumors using a combination of CA 125 and CA 15.3 serum assays. Int J Cancer [Suppl] 3:61
41. 41. Zotter S, Lossnitzer A, Hageman PC, Delemarre JF, Hilkens J, Hilgers J (1987) Immunohistochemical localization of the epithelial marker MAM-6 in invasive malignancies and highly dysplastic adenomas of the large intestine. Lab Invest 57:193
42. 42. Zotter S, Hageman PC, Lossnitzer A, Mooi WJ, Hilgers J (1988) Tissue and tumor distribution of human polymorphic epithelial mucin. Cancer Rev 11-12:55