Reactive oxygen species induce signals that lead to apoptotic DNA degradation in primary CD4+ T cells

Apoptosis

Volumn 10, Issue 6, 2005, Pages 1433-1443

  Pajusto, M ^a   Toivonen, T H ^a   Tarkkanen, J ^a   Jokitalo, E ^b   Mattila, P S ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Apoptosis; DNA fragmentation; Free radicals; Reactive oxygen species; Superoxide anions; T cells

Indexed keywords

CASPASE 3; DNA; GROWTH FACTOR; MANGANESE SUPEROXIDE DISMUTASE; PHOSPHATIDYLSERINE; PORPHYRIN; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL MEMBRANE; CHROMATIN CONDENSATION; DETOXIFICATION; DNA CONTENT; DNA DEGRADATION; DNA STRAND BREAKAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; STAINING; STATISTICAL SIGNIFICANCE;

APOPTOSIS; CASPASES; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; CELLS, CULTURED; CHILD, PRESCHOOL; CHROMATIN; DNA BREAKS; DNA FRAGMENTATION; ELECTRON TRANSPORT; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; INFANT; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL SWELLING; PROTEIN BIOSYNTHESIS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDES; TIME FACTORS;

EID: 28944446779     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-005-2050-5     Document Type: Article

References (42)

1. Danial NN, Korsmeyer SJ. Cell death: Critical control points. Cell 2004; 116: 205-219.
2. Nagata S. Apoptosis by death factor. Cell 1997; 88: 355-365.
3. Thornberry NA, Lazebnik Y. Caspases: Enemies within. Science 1998; 281: 1312-1316.
4. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 1999; 15: 269-290.
5. Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004; 305: 626-629.
6. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998; 94: 481-490.
7. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-1312.
8. Cai J, Jones DP. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J Biol Chem 1998; 273: 11401-11404.
9. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 2001; 15: 2922-2933.
10. Newmeyer DD, Ferguson-Miller S. Mitochondria: Releasing power for life and unleashing the machineries of death. Cell 2003; 112: 481-490.
11. Davis KL, Martin E, Turko IV, Murad F. Novel effects of nitric oxide. Annu Rev Pharmacol Toxicol 2001; 41: 203-236.
12. Hildeman DA, Mitchell T, Teague TK, et al. Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity 1999; 10: 735-744.
13. Hildeman DA, Zhu Y, Mitchell TC, Kappler J, Marrack P. Molecular mechanisms of activated T cell death in vivo. Curr Opin Immunol 2002; 14: 354-359.
14. Hildeman DA, Mitchell T, Aronow B, et al. Control of Bcl-2 expression by reactive oxygen species. Proc Natl Acad Sci USA 2003; 100: 15035-15040.
15. Hildeman DA, Mitchell T, Kappler J, Marrack P. T cell apoptosis and reactive oxygen species. J Clin Invest 2003; 111: 575-581.
16. Tripathi P, Hildeman D. Sensitization of T cells to apoptosis - A role for ROS? Apoptosis 2004; 9: 515-523.
17. Pajusto M, Ihalainen N, Pelkonen J, Tarkkanen J, Mattila PS. Human in vivo-activated CD45R0(+) CD4(+) T cells are susceptible to spontaneous apoptosis that can be inhibited by the chemokine CXCL12 and IL-2, -6, -7, and -15. Eur J Immunol 2004; 34: 2771-2780.
18. Pajusto M, Tarkkanen J, Mattila PS. Platelet endothelial cell adhesion molecule-1 is expressed in adenoidal crypt epithelial cells. Scand J Immunol 2005; 61: 82-86.
19. Petit PX, O'Connor JE, Grunwald D, Brown SC. Analysis of the membrane potential of rat- and mouse-liver mitochondria by flow cytometry and possible applications. Eur J Biochem 1990; 194: 389-397.
20. Castilho RF, Ward MW, Nicholls DG. Oxidative stress, mitochondnal function, and acute glutamate excitotoxicity in cultured cerebellar granule cells. J Neurochem 1999; 72: 1394-1401.
21. Yu LY, Korhonen L, Martinez R, et al. Regulation of sympathetic neuron and neuroblastoma cell death by XIAP and its association with proteasomes in neural cells. Mol Cell Neurosci 2003; 22: 308-318.
22. Tzung SP, Kim KM, Basanez G, et al. Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. Nat Cell Biol 2001; 3: 183-191.
23. Zhuang J, Ren Y, Snowden RT, et al. Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program. J Biol Chem 1998; 273: 15628-15632.
24. Wilhelm S, Roloff S, Hacker G. Inhibition of etoposide-induced apoptotic events by azide. Immunol Lett 1997; 59: 53-59.
25. Gauuan PJ, Trova MP, Gregor-Boros L, et al. Superoxide dismutase mimetics: Synthesis and structure-activity relationship study of MnTBAP analogues. Bioorg Med Chem 2002; 10: 3013-3021.
26. Estevez AG, Crow JP, Sampson JB, et al. Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science 1999; 286: 2498-2500.
27. Adler V, Yin Z, Tew KD, Ronai Z. Role of redox potential and reactive oxygen species in stress signaling. Oncogene 1999; 18: 6104-6111.
28. Zamzami N, Marchetti P, Castedo M, et al. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J Exp Med 1995; 181: 1661-1672.
29. Ziegler U, Groscurth P. Morphological features of cell death. News Physiol Sci 2004; 19: 124-128.
30. Cornelissen M, Philippe J, De Sitter S, De Ridder L. Annexin V expression in apoptotic peripheral blood lymphocytes: An electron microscopic evaluation. Apoptosis 2002; 7: 41-47.
31. Lipscomb LA, Zhou FX, Presnell SR, et al. Structure of DNA-porphyrin complex. Biochemistry 1996; 35: 2818-2823.
32. van Loo G, Schotte P, van Gurp M, et al. Endonuclease G: A mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ 2001; 8: 1136-1142.
33. Susin SA, Lorenzo HK, Zamzami N, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999; 397: 441-446.
34. Higuchi Y. Chromosomal DNA fragmentation in apoptosis and necrosis induced by oxidative stress. Biochem Pharmacol 2003; 66: 1527-1535.
35. Enari M, Sakahira H, Yokoyama H, et al. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998; 391: 43-50.
36. Nagata S, Nagase H, Kawane K, Mukae N, Fukuyama H. Degradation of chromosomal DNA during apoptosis. Cell Death Differ 2003; 10: 108-116.
37. Nakamura H, Nakamura K, Yodoi J. Redox regulation of cellular activation. Annu Rev Immunol 1997; 15: 351-369.
38. Parrish JZ, Yang C, Shen B, Xue D. CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J 2003; 22: 3451-3460.
39. Lipton SA, Choi YB, Pan ZH, et al. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 1993; 364: 626-632.
40. Lin YS, Lin CF, Lei HY, et al. Antibody-mediated endothelial cell damage via nitric oxide. Curr Pharm Des 2004; 10: 213-221.
41. Sade H, Sarin A. Reactive oxygen species regulate quiescent T-cell apoptosis via the BH3-only proapoptotic protein BIM. Cell Death Differ 2004; 11: 416-423.
42. Mayer M, Noble M. N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proc Natl Acad Sci USA 1994; 91: 7496-7500.