Engineering select physical properties of cross-linked red blood cells and a simple a priori estimation of their efficacy as an oxygen delivery vehicle within the context of a hepatic hollow fiber bioreactor

Biotechnology Progress

Volumn 21, Issue 6, 2005, Pages 1700-1707

  Gordon, Jason E ^a   Dare, Matthew E ^a   Palmer, Andre F ^a  

^a University of Notre Dame   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; BLOOD; CELL CULTURE; ELECTROPHORESIS; HEMOGLOBIN; OXYGEN; PHYSICAL PROPERTIES;

BOVINE RED BLOOD CELLS (BRBCS); ELECTROPHORETIC MOBILITY; HOLLOW FIBER; OSMOTIC STABILITY;

BIOREACTORS;

CROSS LINKING REAGENT; GLUTARALDEHYDE; OXYGEN;

ANIMAL; ARTICLE; ARTIFICIAL LIVER; BIOLOGICAL MODEL; BIOMEDICAL ENGINEERING; BIOPHYSICS; BIOREACTOR; BIOTECHNOLOGY; CATTLE; DRUG DELIVERY SYSTEM; ERYTHROCYTE; GEL MOBILITY SHIFT ASSAY; IN VITRO STUDY; METABOLISM; OSMOTIC PRESSURE;

ANIMALS; BIOMEDICAL ENGINEERING; BIOPHYSICS; BIOREACTORS; BIOTECHNOLOGY; CATTLE; CROSS-LINKING REAGENTS; DRUG DELIVERY SYSTEMS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ERYTHROCYTES; GLUTARAL; LIVER, ARTIFICIAL; MODELS, BIOLOGICAL; OSMOTIC PRESSURE; OXYGEN;

BOVINAE;

EID: 28844476652     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp050204p     Document Type: Article

References (42)

1. Piret, J. M.; Cooney, C. L. Model of oxygen-transport limitations in hollow fiber bioreactors. Biotechnol. Bioeng. 1991, 37, 80-92.
2. Allen, J. W.; Bhatia, S. N. Formation of steady-state oxygen gradients in vitro - Application to liver zonation. Biotechnol. Bioeng. 2003, 82, 253-262.
3. Patzer, J. F. Oxygen consumption in a hollow fiber bioartificial liver-revisited. Artif. Organs 2004, 28, 83-98.
4. Nishikawa, M.; Uchino, J.; Matsushita, M.; Takahashi, M.; Taguchi, K.; Koike, M.; Kamachi, H.; Kon, H. Optimal oxygen tension conditions for functioning cultured hepatocytes in vitro. Artif. Organs 1996, 20, 169-177.
5. Shi, Y.; Sardonini, C. A.; Goffe, R. A. The use of oxygen carriers for increasing the production of monoclonal antibodies from hollow fibre bioreactors. Res. Immunol. 1998, 149, 576-587.
6. Ju, L. K.; Lee, J. F.; Armiger, W. B. Enhancing oxygen-transfer in bioreactors by perfluorocarbon emulsions. Biotechnol. Prog. 1991, 7, 323-329.
7. Jones, J. A. Red-blood-cell substitutes - Current status. Br. J. Anaesth. 1995, 74, 697-703.
8. Everse, J.; Hsia, N. The toxicities of native and modified hemoglobins. Free Radical Biol. Med. 1997, 22, 1075-1099.
9. Gordon, J.; Palmer, A. Impact of increased oxygen delivery via bovine red blood cell supplementation of culturing media on select metabolic and synthetic functions of C3A hepatocytes maintained within a hollow fiber bioreactor. Artif. Cells, Blood Substitutes, Immobilization Biotechnol. 2005, 33, 297-306.
10. Catapano, G.; DeBartolo, L.; Lombardi, C. P.; Drioli, E. The effect of oxygen transport resistances on the viability and functions of isolated rat hepatocytes. Int. J. Artif. Organs 1996, 19, 61-71.
11. Hay, P. D.; Veitch, A. R.; Smith, M. D.; Cousins, R. B.; Gaylor, J. D. S. Oxygen transfer in a diffusion-limited hollow fiber bioartificial liver. Artif. Organs 2000, 24, 278-288.
12. Smith, M. D.; Cairns, D. E.; Veitch, R. B.; Cousins, R. B.; Gaylor, J. D. S. Analysis of oxygen transfer in hollow fiber hepatocyte bioreactors. Artif. Organs 1994, 21, 531.
13. Riess, J. G. Oxygen carriers ("blood substitutes")-Raison d'Etre, chemistry, and some physiology. Chem. Rev. 2001, 101, 2797-2919.
14. Vassar, P.; Hards, J.; Brooks, D.; Hagenberger, B.; Seaman, G. Physicochemical effects of aldehydes on the human erythrocyte. J. Cell Biol. 1972, 58, 809-818.
15. Sabatini, D.; Bensch, K.; Barrnett, R. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. J. Cell Biol. 1963, 17, 19.
16. + on the oxygen binding properties of glutaraldehyde-polymerized bovine hemoglobin-based blood substitutes. Biotechnol. Prog. 2004, 20, 1543-1549.
17. Eike, J. H.; Palmer, A. F. Effect of glutaraldehyde concentration on the physical properties of polymerized hemoglobin-based oxygen carriers. Biotechnol. Prog. 2004, 20, 1225-1232.
18. 4 concentration and reaction time on physical properties of glutaraldehyde-polymerized hemoglobin. Biotechnol. Prog. 2004, 20, 946-952.
19. Eike, J. H.; Palmer, A. F. Oxidized mono-, di-, tri-, and polysaccharides as potential hemoglobin cross-linking reagents for the synthesis of high oxygen affinity artificial blood substitutes. Biotechnol. Prog. 2004, 20, 953-962.
20. Jeong, S. T.; Lee, S. H.; Byun, S. M. Glutaraldehyde cross-linking of red blood cells by using a hemodialyzer. Biotechnol. Tech. 1998, 10, 815-820.
21. Arevalo, F.; Bellelli, A.; Brancaccio, A.; Ippoliti, R.; Lendaro, E.; Brunori, M. Biochemical and rheodynamic properties of red-blood-cells cross-linked with glutaraldehyde. Biotechnol. Appl. Biochem. 1992, 16, 195-200.
22. Bellelli, A.; Benedetti, P. L.; Coletta, M.; Ippoliti, R.; Brunori, M. Human-erythrocytes cross-linked with glutaraldehyde general-properties and significance as a blood substitute. Biochem. Biophys. Res. Commun. 1988, 156, 970-977.
23. Krogh, A. The number and distribution of capillaries in muscles with calculations of the oxygen pressurehead necessary for supplying the tissue. J. Physiol. 1919, 52, 409-415.
24. McClelland, R. E.; MacDonald, J. M.; Coger, R. N. Modeling O-2 transport within engineered hepatic devices. Biotechnol. Bioeng. 2003, 82, 12-27.
25. Oser, B. L. Hawk's Physiological Chemistry; McGraw-Hill: New York, 1965.
26. Voet, D.; Voet, J. G. Biochemistry, 2nd ed.; John Wiley & Sons: New York, 1995,
27. Fournier, R. L. Basic Transport Phenomena in Biomedical Engineering; Taylor & Friends: Philadelphia, 1999; p 90.
28. Degroot, H.; Noll, T.; Sies, H. Oxygen dependence and subcellular partitioning of hepatic menadione-mediated oxygen-uptake - Studies with isolated hepatocytes, mitochondria, and microsomes from rat-liver in an oxystat system. Arch. Biochem. Biophys. 1985, 243, 556-562.
29. Berg, J.; Tymoczko, J.; Stryer, L. Biochemistry, 5th ed.; W. H. Freeman and Company: New York, 2002; p 894.
30. Heard, D. H.; Seaman, G. V. F. The action of lower aldehydes on the human erythrocyte. Biochim. Biophys. Acta 1961, 53, 366-374.
31. Burt, H. M.; Jackson, J. K.; Kim, K. J. K. Role of membrane-proteins in monosodium urate crystal-membrane interactions. 1. Effect of pretreatment of erythrocyte-membranes with glutaraldehyde and neuraminidase. J. Rheumatol. 1990, 17, 1353-1358.
32. Mirossay, L.; Mojzis, J.; Jandosekova, M.; Lukacin, S.; Nicak, A. Comparison of two methods in erythrocyte microrheology determination using glutaraldehyde-treated cells. Clin. Hemorheol. Microcirc. 1997, 17, 187-192.
33. Faivre, B.; Menu, P.; Labrude, P.; Vigneron, C. Hemoglobin autooxidation/oxidation mechanisms and methemoglobin prevention or reduction processes in the bloodstream - Literature review and outline of autooxidation reaction. Artif. Cells, Blood Substitutes, Immobilization Biotechnol. 1998, 26, 17-26.
34. Morrison, S. J.; Csete, M.; Groves, A. K.; Melega, W.; Wold, B.; Anderson, D. J. Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells. J. Neurosci. 2000, 20, 7370-7376.
35. Studer, L.; Csete, M.; Lee, S. H.; Kabbani, N.; Walikonis, J.; Wold, B.; McKay, R. Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. J. Neurosci. 2000, 20, 7377-7383.
36. Arifin, D. R.; Palmer, A. F. Polymersome encapsulated hemoglobin (PEH): A novel type of artificial blood substitute. Biomacromolecules 2005, 6, 2172-2181.
37. Arifin, D. R.; Palmer, A. F. Stability of liposome encapsulated hemoglobin dispersions. Artif. Cells, Blood Substitutes, Immobilization Biotechnol. 2005, 33, 113-136.
38. Arifin, D. R.; Palmer, A. F. Physical properties and stability mechanisms of poly(ethylene glycol) conjugated liposome encapsulated hemoglobin. Artif. Cells, Blood Substitutes, Immobilization Biotechnol. 2005, 33, 137-162.
39. Arifin, D. R.; Palmer, A. F. Determination of size distribution and encapsulation efficiencies of liposomes encapsulated hemoglobin by asymmetric flow field-flow fractionation and multi-angle light scattering. Biotechnol. Prog. 2003, 9, 1798-1811.
40. Li, S.; Nickels, J.; Palmer, A. F. Liposome-encapsulated actin-hemoglobin (LEAcHb) artificial blood substitutes. Biomaterials 2005, 26, 3759-3769.
41. Patton, J.; Palmer, A. Photopolymerization of bovine hemoglobin entrapped nanoscale hydrogel particles within liposomal reactors for use as an artificial blood substitute. Biomacromolecules 2005, 6, 414-424.
42. Patton, J.; Palmer, A. Engineering temperature-sensitive hydrogel nanoparticles entrapping hemoglobin as a novel type of oxygen carrier. Biomacromolecules 2005, 6, 2204-2212.