A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival

FEBS Letters

Volumn 579, Issue 30, 2005, Pages 6814-6820

  Andela, Valentine B ^a,b   Schwarz, Edward M ^a   O'Keefe, Regis J ^a   Puzas, Edward J ^a   Rosenblatt, Joseph D ^b   Rosier, Randy N ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

Oxidation; Apoptosis; Glycolysis; NF B; Oxidative stress; Survival

Indexed keywords

ANTIOXIDANT; CELL NUCLEUS RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE;

ADAPTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL GROWTH; CELL METABOLISM; CELL RESPIRATION; CELL SURVIVAL; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; ENERGY METABOLISM; FATTY ACID OXIDATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC MODEL; GENOME; MACROMOLECULE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME; MICE; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATION-REDUCTION; PROTEINS; REACTIVE OXYGEN SPECIES;

ANIMALIA; MURINAE;

EID: 28844456987     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.11.018     Document Type: Article

References (50)

1. A.S. Baldwin Jr. The NF-kappa Band I kappa B proteins: new discoveries and insights Ann. Rev. Immunol. 14 1996 649 683
2. S. Gerondakis, M. Grossman, Y. Nakamur, T. Pohl, and R. Grumont Genetic approaches to understand Rel/NF-κB and Iκ B function: transgenics and knockouts Oncogene 18 1999 6888 6895
3. S. Ghosh, M.J. May, and E.B. Kopp NF-κB and Rel proteins: evolutionary conserved mediators of immune responses Annu. Rev. Immunol. 16 1998 225 260
4. P.A. Baeuerle, and T. Henkel Function and activation of NF-kappa B in the immune system Ann. Rev. Immunol. 12 1994 141 179
5. J.L. Pomerantz, and D. Baltimore Two pathways to NF-κB Mol. Cell. 10 2002 693 701
6. M. Karin How NF-κB is activated: the role of the IκB kinase (IKK) complex Oncogene 18 1999 6867 6874
7. L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867
8. F.R. Greten, L. Eckmann, T.F. Greten, J.M. Park, Z.W. Li, L.J. Egan, M.F. Kagnoff, and M. Karin IKKb links inflammation and tumorigenesis in a mouse model of colitis-associated cancer Cell. 118 2004 285 296
9. T.C. Hsu, R. Nair, P. Tulsian, C.E. Camalier, G.A. Hegamyer, M.R. Young, and N.H. Colburn Transformation non responsive cells owe their resistance to lack of p65/NFkappaB activation Cancer Res. 61 2001 4160 4168
10. B. Rayet, and C. Gelinas Aberrant Rel/NFkappaB genes and activity in human cancer Oncogene 18 1999 6938 6947
11. T.S. Finco, J.K. Westwick, J.L. Norris, A.A. Beg, C.J. Der, and A.S. Baldwin Jr. Oncogenic H-Ras induced signaling activity which is required for cellular transformation J. Biol. Chem. 272 1997 24113 24116
12. T.D. Gilmore Clinically Relevant findings J. Clin. Investig. 100 1997 2935 2936
13. A.S. Baldwin Control of oncogenesis and cancer therapy resistance by the transcription factor NFkappaB J. Clin. Investig. 107 2001 241 246
14. S. Huang, C.A. Pettaway, H. Uehara, C.D. Bucana, and I.J. Fidler Blockade of NFkappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion and metastasis Oncogene. 20 2001 4188 4197
15. V.B. Andela, E.M. Schwarz, J.E. Puzas, R.J. O'Keefe, and R.N. Rosier Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by NFkappaB Cancer Res. 60 2000 6557 6562
16. E. Kopp, and S. Ghosh Inhibition of NFkappaB by soduim salicylate and aspirin Science 265 1994 956 959
17. C. Wahl, S. Liptay, G. Adler, and R.M. Schmid Sulfasalazine: a potent and specific inhibitor of NFkappaB J. Clin. Invest. 101 1998 1163 1174
18. M. McKelvey, E.T. Ho, S.R. McKeown, S.R. Johnston, P.J. McCarthy, N. Pajab, and C.S. Downes Emerging applications of the single cell gel electrophoresis (comet) assay. I- Management of invasive transitional cell huma bladder carcinoma. II. Fluorescent in situ hybridization comets for the identification of damaged and repaired DNA sequences in individual cells Mutagenesis 13 1998 1 8
19. C. Helma, and M. Uhl A public domain image-analysis for the single-cell gel-electrophoresis (comet) assay Mutation Res. 466 2000 9 15
20. T.D. Gilmore Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel Oncogene 18 1999 6925 6937
21. V.B. Andela Functional antagonism between NFkappaB and Nuclear receptors: Implications in carcinogenesis and strategies for optimal cancer chemopreventive interventions Curr. Cancer Drug Targets 4 2004 337 344
22. V.B. Andela, and R.N. Rosier The proteosome inhibitor, MG132, attenuates retinoic acid receptor trans-activation but enhances trans-repression of NFkappaB: potential relevance to chemo-preventive interventions with retinoids Mol. Cancer 22 2004 1 8
23. A. Boveris, N. Oshino, and B. Chance The cellular production of hydrogen peroxide Biochem. J. 128 1972 617 630
24. V.P. Skulachev Q. Rev. Biophys. 29 1996 169 202
25. H. Wiseman, and B. Halliwell Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression of cancer Biochem J. 331 1996 17 29
26. S. Toyokuni, K. Okamoto, J. Yodoi, and H. Hiai Persistent oxidative stress in cancer FEBS Lett. 358 1995 1 3
27. S.Carew Jennifer, and Huang Peng Mitochondrial defects in cancer Mol. Cancer 1 2002 1 9
28. S.J. Modica-Napolitano, and K.K. Singh Mitochondria as targets for detection and treatment of cancer Exp. Rev. Mol. Med. 11 April 2002 Available from: http://www.ermm.cbcu.cam.ac.uk/02004453h.htm
29. O. Warburg On the origin of cancer cells Science 123 1930 309 314
30. D.R. Spitz, J.E. Sim, L.A. Ridnour, S.S. Galoforo, and Y.J. Lee Glucose deprivation induced oxidative stress in human tumor cells. A fundamental defect in metabolism? Ann. N. Y. Acad. Sci. 899 2000 349 362
31. M. Guppy, P. Leedman, X. Zu, and V. Russell Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-breast cancer cells Biochem. J. 364 2002 309 315
32. A. Ramanathan, C. Wang, and S.L. Schreiber Pertubational profiling of a cell-line model of tumorigenesis by using metabolic measurements Proc. Natl. Acad. Sci. 102 2005 5992 5997
33. D.G. Nicholls Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease Int. J. Biochem. Cell. Biol. 34 2002 1372 1381
34. G.A. Francis, E. Fayard, F. Picard, and J. Auwerx Nuclear receptors and the control of metabolism Ann. Rev. Physiol. 65 2002 261 311
35. A. Chawla, J.J. Repa, R.M. Evans, and D.J. Mangelsdorf Nuclear receptors and lipid physiology: opening the x-files Science 294 2001 1866 1870
36. G. Benoit, M. Malewicz, and T. Perlmann Digging deep into the pockets of orphan nuclear receptors: insights from structural studies Trends Cell Biol. 14 2004 369 376
37. V.B. Andela, S. Altuwaijri, J. Wood, and R.N. Rosier Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemopreventive activity of PPAR gamma agonists FEBS Lett. 579 2005 1765 1769
38. P.J. Randle, D.A. Priestman, S.C. Mistry, and A. Halsall J. Cell. Biochem. 55 Suppl. 1994 1 11
39. S.I. Taylor, C. Mukherjee, and R.L. Jungas Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio J. Biol. Chem. 250 1975 2028 2035
40. A. Tovar-Mendez, J.A. Miernyk, and D.D. Randall Regulation of pyruvate dehydrogenase complex activity in plants Eur. J. Biochem. 270 2003 1043 1049
41. Y.E. Bogaert, R.E. Rosenthal, and G. Fiskum Post-ischemic inhibition of cerebral cortex pyruvate dehydrogenase Free Radic. Biol. Med. 16 1994 811 820
42. R. Spahr, I. Probst, and H.M. Piper Substrate utilization of adult cardiac myocytes Basic Res. Cardiol. 80 Suppl. 1 1985 53 56
43. T.M. Huss, and D.P. Kelly Nuclear receptor signaling and cardiac energetics 95 2004 568 578
44. M.L. Eboli, and A. Pasquini Transformation linked decrease of pyruvate dehydrogenase complex in human epidermis Cancer Lett. 85 1994 239 243
45. P. Schonfeld, A.B. Wojtczak, M.J. Geelen, W. Kunz, and L. Wojtczak On the mechanism of the so-called uncoupling effect of medium- and short-chain fatty acids Biochim. Biophys. Acta 936 1998 280 288
46. 2 by mitochondria in the resting state FEBS Lett. 435 1998 215 218
47. T.D. Lockwood Redox control of protein degradation Antioxid. Redox Signal. 2 2000 851 878
48. S. Filosa, A. Fico, F. Paglialunga, M. Balsetrieri, A. Crooke, P. Verde, P. Abrescia, J.M. Bautista, and G. Martini Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene deleted mouse embryonic stem cells subjected to oxidative stress Biochem. J. 320 2003 935 943
49. L.G. Boros, D.T. Brackett, and G.G. Harrigan Metabolic biomarker and kinase drug target discovery in cancer using stable isotope-based dynamic metabolic profiling (SIDMAP) Curr. Cancer Drug Targets. 3 2003 445 453
50. A.J. Saldanha Java Treeview-extensible visualization of microarray data Bioinformatics 20 2004 3246 3248