Inflammation and TGFβ1: Lessons from the TGFβ1 null mouse

Research in Immunology

Volumn 148, Issue 7, 1997, Pages 453-456

  Kulkarni, A B ^a   Karlsson, S ^b  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL TISSUE; EMBRYO DEVELOPMENT; HEMATOPOIESIS; IMMUNOREGULATION; INFLAMMATION; MOUSE; NONHUMAN; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; SHORT SURVEY; WOUND HEALING;

EID: 0031469204     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2494(97)82669-7     Document Type: Article

References (27)

1. Bonyhady, M., Rusholmes, S.A.B., Cousins, F.M., Su, H.C., Biron, C.A., Farrall, M. & Akhurst, R.J. (1996), Mapping of a major genetic modifier of embryonic lethality in TGF-ß1 knockout mice. Nature Gen., 15, 207-211.
2. Brandes, M.E., Allen, J.B., Ogawa, Y. & Wahl, S.M. (1991), Transforming growth factor ß1 suppresses acute and chronic arthritis in experimental animals. J. Clin. Invest., 87, 1108-1113.
3. Dang, H., Geiser, A.G., Letterio, J.J., Nakbayashi, T., Kong, L., Ferrnandes, G. & Talal, N. (1995), SLE-like autoantibodies and Sjorgen's syndrome-like lymphoproliferation in TGFß1 knockout mice. J. Immunol., 155, 3205-3212.
4. Dickson, M.C., Martin, J.S., Cousins, F.M., Kulkarni, A.B., Karlsson, S. & Akhurst, R.J. (1995), Defective haematopoiesis and vasculogenesis in transforming growth factor-ß1 knockout mice. Development, 121, 1845-1854.
5. Diebold, R.J., Eis, M.J., Yin, M., Ormsby, I., Boivin, G.P., Darrow, B.J., Saffitz, J.E. & Doetschman, T. (1995), Early-onset multifocal inflammation in the transforming growth factor ß1-null mouse is lymphocyte-mediated. Proc. Natl. Acad. Sci. USA, 92, 12215-12219.
6. Geiser, A.G., Letterio, J.J., Kulkarni, A.B., Karlsson, S., Roberts, A.B. & Sporn, M.B. (1993), Transforming growth factor ß1 (TGF-ß1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-ß1 null mouse phenotype. Proc. Natl. Acad. Sci. USA, 90, 9944-9948.
7. Hines, K.L., Kulkarni, A.B., McCarthy, J.B., Tian, H., Ward, J.M., Christ, M., McCartney-Francis, N.L., Furcht, L.T., Karlsson, S. & Wahl, S. (1994), Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor ß1 knockout mice. Proc. Natl. Acad. Sci. USA, 91, 5187-5191.
8. Kulkarni, A.B., Huh, C-G., Becker, D., Geiser, A., Lyght, M., Flanders, K.C., Roberts, A.B., Sporn, M.B., Ward, J.M. & Karlsson, S. (1993), Transforming growth factor ß1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA, 90, 770-774.
9. Kulkarni, A.B., Ward, J.M., Yaswen, L.R., Mackall, C.L., Bauer, S.R., Huh, C.G., Gress, R.E. & Karlsson, S. (1995), pathology of TGF-ß1 null mice. Am. J. Pathol., 146, 264-275.
10. Kulkarni, A.B. & Letterio, J.J. (1996), The transforming growth factor-ß1 knockout mouse: the phenotype and its implications for TGF-ß1 function, in "Cytokine Knockouts". (Durum S., Muegge K., Totowa, NJ) pp. 373-404, USA Humana Press.
11. Letterio, J.J., Geiser, A.G., Kulkarni, A.B., Roche, N.S., Sporn, M.B. & Roberts, A.B. (1994), Maternal rescue of transforming growth factor-ß1 null mice. Science, 264, 1936-1938.
12. Letterio, J.J. & Roberts, A.B. (1996), TGF-ß1 deficient mice: identification of isoform specific activities in vivo. J. Leukocyte Biol., 59, 769-774.
13. Letterio, J.J., Geiser, A.G., Kulkarni, A.B., Dang, H., Kong, L., Nakabayashi, T., Mackall, C.L., Gress, R.E. & Roberts, A.B. (1996), Autoimmunity associated with TGF-ß1 deficiency in mice is dependent on MHC class II antigen expression. J. Clin. Invest., 98, 2109-2119.
14. Lowrance, J.H., O'Sullivan, F.X., Caver, T.E., Waegell, W. & Gresham, H.D. (1994), Spontaneous elaboration of transforming growth factor suppresses host defense against bacterial infection in autoimmune MRL/lpr mice. J. Exp. med., 180, 1693-1703.
15. Massagué, J. (1990), The transforming growth factor-ß family. Annu. Rev. Cell Biol., 6, 597-641.
16. McCartney-Francis, N.L. & Wahl, S.M. (1994), Transforming growth factor-ß: a matter of life and death. J. leukocyte Biol., 55, 401-409.
17. McCartney-Francis, N.L., Mizel, D.E., Redman, R.S., Frazier-Jessen, M., Panek, R.B., Kulkarni, A.B., Ward, J.M., McCarthy, J.B. & Wahl, S.M. (1996), Autoimmune Sjogren's-like lesions in salivary glands of TGF-ß1 deficient mice are inhibited by adhesion blocking peptides. J. Immunol., 175, 1306-1312.
18. Miller, A., Lider, O., Roberts, A.B., Sporn, M.B. & Weiner, H.L. (1992), Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor-ß after antigen-specific triggering. Proc. Natl. Acad. Sci. USA, 89, 421-425.
19. Oshima, M., Oshima, H. & Taketo, M.M. (1996), TGF-ß receptors type II deficiency results in defects of yolk sac hematpoiesis and vasculogenesis. Dev. Biol., 179, 297-302.
20. Racke, M.K., Dhib-Jalbut, S., Cannella, B., Albert, P.S., Raine, C.S. & McFarlin, D.E. (1991). Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-ß1. J. Immunol., 146, 3012-3017.
21. Racke, M.K., Cannella, B., Albert, P., Sporn, M., Raine, C.S. & McFarlin, D.E. (1992), Evidence of endogenous regulatory function of transforming growth factor-ß1 in experimental allergic encephalomyelitis. Int. Immunol., 4, 615-620.
22. Roberts, A.B. & Sporn, M.B. (1993), Physiological actions and clinical applications of transforming growth factor-ß (TGF-ß). Growth Factors, 8, 1-9.
23. Shull, M.M., Ormsby, I., Kier, A.B., Pawlowski, S., Diebold, R.J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., Annunziata, N. & Doetschman, T. (1992), Targeted disruption of the mouse transforming growth factor-ß1 gene results in multifocal inflammatory disease. Nature, 359, 693-699.
24. Sinha, A.A., Lopez, M.T. & McDevitt, H.O. (1990), Autoimmune diseases: the failure of self tolerance. Science, 248, 1380-1388.
25. Vodovotz, Y., Geiser, A.G., Chesler, L., Letterio, J.J., Cambell, A., Lucia, M.S., Sporn, M.B. & Roberets, A.B. (1996), Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor ß1 null mouse. J. Exp. med., 183, 2337-2342.
26. Wahl, S.M. (1992), Transforming growth factor-ß (TGF-ß) in inflammation: a cause and a cure. J. Clin. Immunol., 12, 61-74.
27. Yaswen, L., Kulkarni, A.B., Frederickson, T., Mittleman, B., Schiffmann, R., Payne, S., Longenecker, G., Mozes, E. & Karlsson, S. (1996), Autoimmune manifestations in the transforming growth factor-ß1 knockout mice. Blood, 87, 1439-1445.