A comet assay study reveals that aluminium induces DNA damage and inhibits the repair of radiation-induced lesions in human peripheral blood lymphocytes

Toxicology Letters

Volumn 161, Issue 1, 2006, Pages 27-36

  Lankoff, Anna ^a   Banasik, Anna ^a   Duma, Anna ^a   Ochniak, Edyta ^a   Lisowska, Halina ^a   Kuszewski, Tomasz ^b   Góźdź, Stanisław ^b   Wojcik, Andrzej ^a,c  

^a JAN KOCHANOWSKI UNIVERSITY   (Poland)

^b Swietokrzyskie Centrum Onkologii Poland   (Poland)

^c INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY   (Poland)

Author keywords

Aluminium; Comet assay; DNA repair; DNA single strand breaks; Human lymphocytes; Ionizing radiation; Oxidative DNA damage

Indexed keywords

ALUMINUM; ALUMINUM CHLORIDE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; DNA GLYCOSYLTRANSFERASE; ENDONUCLEASE; SINGLE STRANDED DNA;

ADULT; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DAMAGE; COMET ASSAY; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DOSE RESPONSE; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; IONIZING RADIATION; LYMPHOCYTE; OXIDATION; PRIORITY JOURNAL; RADIATION INJURY;

ADULT; ALUMINUM; APOPTOSIS; CELL CYCLE; COMET ASSAY; DNA; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; LYMPHOCYTES; PURINES; PYRIMIDINES; TIME FACTORS;

EID: 28844448158     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.07.012     Document Type: Article

References (43)

1. T.M. Ansari, I.L. Marr, and N. Tariq Heavy metals in marine pollution perspective - a mini review J. Appl. Sci. 4 2004 1 20
2. A. Banasik, A. Lankoff, A. Piskulak, K. Adamowska, H. Lisowska, and A. Wojcik Aluminium-induced micronuclei and apoptosis in human peripheral blood lymphocytes treated during different phases of the cell cycle Environ. Toxicol. 20 2005 402 406
3. G. Berthon Aluminium speciation in relation to aluminium bioavailability, metabolism and toxicity Coord. Chem. Rev. 228 2002 319 341
4. S. Boiteux, T.R. O'Connor, and J. Laval Formamidopyrimidine-DNA glycosylase of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein EMBO J. 6 1987 3177 3183
5. S.W. Cho, and G.Y. Kim Aluminum interrupts the formation of alkaline-ribonuclease-inhibitor complex from bovine brain Eur. J. Biochem. 202 1991 107 111
6. M. Christmann, M.T. Tomicic, W.P. Roos, and B. Kaina Mechanisms of human DNA repair: an update Toxicology 193 2003 3 34
7. A.R. Collins, S.J. Duthie, and V.L. Dobson Direct enzymatic detection of endogenous oxidative base damage in human lymphocyte DNA Carcinogenesis 14 1993 1733 1735
8. J.-G. Cui, V. Colangelo, T.P.A. Kruck, H. Kuroda, T. Lialin, J. Schurr, N.G. Bazan, and W.J. Lukiw Aluminium triggers NF-kB signaling, pro-inflammatory and pro-apoptotic gene expression in human neural cells in primary culture: implications for Alzheimer's disease Proceedings of the Fifth Kiel Meeting on Aluminium 22-25 February 2003
9. C.B. Dobson, J.P. Day, S.J. King, and R.F. Itzhaki Location of aluminium and gallium in human neuroblastoma cells treated with metal-chelating agent complexes Toxicol. Appl. Pharmacol. 152 1998 145 152
10. P.W. Doetsch, W.D. Henner, R.P. Cunningham, J.H. Toney, and D.E. Holland A highly conserved endonuclease activity present in Escherichia coli, bovine and human cells recognizes oxidative DNA damage at sites of pyrimidines Mol. Cell. Biol. 7 1987 26 32
11. J.L. Greger Aluminium metabolism Annu. Rev. Nutr. 13 1993 43 63
12. J.S. Hanas, and C.G. Gunn Inhibition of transcription factor IIIA-DNA interactions by xenobiotic metal ions Nucl. Acids Res. 24 1996 924 930
13. A. Hartmann, M. Schumacher, U. Plappert-Helbig, P. Lowe, W. Suter, and L. Mueller Use of the alkaline in vivo Comet assay for mechanistic genotoxicity investigations Mutagenesis 19 2004 51 59
14. A. Hartwig Carcinogenicity of metal compounds: possible role of DNA repair inhibition Toxicol. Lett. 102/103 1998 235 239
15. A. Hartwig, M. Asmuss, I. Ehleben, U. Herzer, D. Kostelac, A. Pelzer, T. Schwerdtle, and A. Burkle Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms Environ. Health Perspect. 110 2002 797 799
16. A. Hartwig, R. Schlepegrell, H. Dally, and M. Hartmann Interaction of carcinogenic metal compounds with deoxyribonucleic acid repair processes Ann. Clin. Lab. Sci. 26 1996 31 38
17. A. Hartwig, and T. Schwerdtle Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications Toxicol. Lett. 127 2002 47 54
18. S. Kawanishi, Y. Hiraku, M. Murata, and S. Oikawa The role of metals in site-specific DNA damage with reference to carcinogenesis Free Radic. Biol. Med. 32 2002 822 832
19. K. Konca, A. Lankoff, A. Banasik, H. Lisowska, T. Kuszewski, S. Gozdz, Z. Koza, and A. Wojcik A cross platform public domain PC image analysis program for the comet assay Mutat. Res. 534 2003 15 20
20. S. Koundrioukoff, S. Polo, and G. Almouzni Interplay between chromatin and cell cycle checkpoints in the context of ATR/ATM-dependent checkpoints DNA Repair (Amst.) 3 2004 969 978
21. J.H. Li, and T.G. Rossman Inhibition of DNA ligase activity by arsenite: a possible mechanism of its comutagenesis Mol. Toxicol. 2 1989 1 9
22. W. Li, K.K. Ma, W. Sun, and H.K. Paudel Phosphorylation sensitizes microtubule-associated protein tau to Al(3+)-induced aggregation Neurochem. Res. 23 1998 1467 1476
23. M.P. Longhese, M. Clerici, and G. Lucchini The S-phase checkpoint and its regulation in Saccharomyces cerevisiae Mutat. Res. 532 2003 41 58
24. J.P. Mackay, and M. Crossley Zinc fingers are sticking together Trends Biochem. Sci. 23 1998 1 4
25. H.E. Matsumoto, E. Hirasawa, H. Torikai, and E. Takahashi Localisation of absorbed aluminium in pea root and its binding to nucleic acid Plant Cell Physiol. 127 2004
26. V.J. McKelvey-Martin, N. Melia, I.K. Walsh, S.R. Johnston, C.M. Hughes, S.E. Lewis, and W. Thompson Two potential clinical applications of the alkaline single-cell gel electrophoresis assay: (1) Human bladder washings and transitional cell carcinoma of the bladder; and (2) Human sperm and male infertility Mutat. Res. 375 1997 93 104
27. L. Migliore, L. Cocchi, C. Nesti, and E. Sabbioni Micronuclei assay and FISH analysis in human lymphocytes treated with six metal salts Environ. Mol. Mutagen. 34 1999 279 284
28. L. Migliore, and F. Coppede Genetic and environmental factors in cancer and neurodegenerative diseases Mutat. Res. 512 2002 135 153
29. P. Nayak Aluminum: impacts and disease Environ. Res. 89 2002 101 115
30. P.L. Olive, J.P. Banath, and R.E. Durand Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay Radiat. Res. 122 1990 86 94
31. P.L. Olive, G. Frazer, and J.P. Banath Radiation-induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay Radiat. Res. 136 1993 130 136
32. K.S. Rao, B.S. Rao, D. Vishnuvardhan, and K.V. Prasad Alteration of superhelical state of DNA by aluminium (Al) Biochim. Biophys. Acta 1172 1993 17 20
33. A.K. Roy, A. Sharma, and G. Talukder A time-course study on effects of aluminium on mitotic cell division in Allum sativum Mutat. Res. 227 1989 221 226
34. H. Shi, L.G. Hudson, and K.J. Liu Oxidative stress and apoptosis in metal ion-induced carcinogenesis Free Radic. Biol. Med. 37 2004 582 593
35. N.P. Singh, R.R. Tice, R.E. Stephensen, and E. Schneider A microgel electrophoresis technique for the direct quantitation of DNA damage and repair in individual fibroblasts cultured on microscope slides Mutat. Res. 252 1991 289 296
36. S. Takahashi, E. Takeda, Y. Kubota, and R. Okayasu Inhibition of repair of radiation-induced DNA double-strand breaks by nickel and arsenite Radiat. Res. 154 2000 686 691
37. P. Villani, P.L. Altavista, L. Castaldi, G. Leter, and E. Cordelli Analysis of DNA oxidative damage related to cell proliferation Mutat. Res. 464 2000 229 237
38. S. Wada, T.V. Khoa, Y. Kobayashi, T. Funayama, K. Yamamoto, M. Natsuhori, and N. Ito Detection of radiation-induced apoptosis using the comet assay J. Vet. Med. Sci. 65 2003 1161 1166
39. R.J. Ward, Y. Zhang, and R.R. Crichton Aluminium toxicity and iron homeostasis J. Inorg. Biochem. 87 2001 9 14
40. K. Woźniak, and J. Blasiak Free radicals-mediated induction of oxidized DNA bases and DNA-protein cross-links by nickel chloride Mutat. Res. 514 2002 233 243
41. C.X. Xie, J. StPyrek, W.H. Porter, and R.A. Yokel Hydroxyl radical generation in rat brain is initiated by iron but not aluminium as determined by microdialysis with salicylate trapping and GC-MS analysis Agric. Food Chem. 47 1999 4606 4610
42. M.I. Yousef Aluminium-induced changes in hemato-biochemical parameters, lipid peroxidation and enzyme activities of male rabbits: protective role of ascorbic acid Toxicology 199 2004 47 57
43. P. Zatta, T. Kiss, M. Suwalsky, and G. Berthon Aluminium(III) as a promoter of cellular oxidation Coord. Chem. Rev. 228 2002 271 284