Opposing effects of phorbol-12-myristate-13-acetate, an activator of protein kinase C, on the signaling of structurally related human dopamine D1 and D5 receptors

Journal of Neurochemistry

Volumn 95, Issue 5, 2005, Pages 1387-1400

  Jackson, Adele ^b   Sedaghat, Keyvan ^b   Minerds, Kirsty ^b   James, Carolyn ^b   Tiberi, Mario ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b NONE

Author keywords

D1 like receptors; Desensitization; Dopamine; G protein coupling; Phorbol ester; Protein kinase C

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; BISINDOLYLMALEIMIDE; BISINDOLYLMALEIMIDE I; CALCIUM ION; CYCLIC AMP; DOPAMINE 1 RECEPTOR; DOPAMINE 5 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROTRANSMITTER; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA I; PROTEIN KINASE C BETA II; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ETA; PROTEIN KINASE C GAMMA; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C THETA; PROTEIN KINASE D; PROTEIN KINASE D MU; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL STRAIN HEK293; CONTROLLED STUDY; DESENSITIZATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOLECULAR INTERACTION; NERVE CELL; NEUROTRANSMISSION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECOND MESSENGER; SIGNAL TRANSDUCTION; WHOLE CELL;

1-METHYL-3-ISOBUTYLXANTHINE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARBAZOLES; CELL LINE, TRANSFORMED; CYCLIC AMP; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INDOLES; PHORBOL ESTERS; PHOSPHODIESTERASE INHIBITORS; PROTEIN ISOFORMS; PROTEIN KINASE C; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

MAMMALIA;

EID: 28844431579     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03476.x     Document Type: Article

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