Hemin prevents cardiac and diaphragm mitochondrial dysfunction in sepsis

Free Radical Biology and Medicine

Volumn 40, Issue 1, 2006, Pages 127-137

  Supinski, Gerald S ^a   Callahan, Leigh A ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Endotoxin; Free radicals; Heme oxygenase; Mitochondria; Sepsis

Indexed keywords

ENDOTOXIN; ENZYME INDUCING AGENT; FREE RADICAL; HEME OXYGENASE; HEMIN; LIPOPOLYSACCHARIDE; NITRATE; NITRITE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; COMPARATIVE STUDY; CONTROLLED STUDY; DIAPHRAGM DISEASE; ENZYME INDUCTION; HEART FAILURE; HEART FUNCTION; HEART MITOCHONDRION; HEART PROTECTION; HEART RATE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SEPSIS; TISSUE INJURY;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD PRESSURE; DIAPHRAGM; ENDOTOXINS; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; FREE RADICALS; HEART RATE; HEME OXYGENASE (DECYCLIZING); HEMIN; LIPID PEROXIDATION; MALE; MITOCHONDRIA, HEART; NITRATES; NITRITES; OXIDATIVE PHOSPHORYLATION; RATS; SEPSIS;

ANIMALIA;

EID: 28744455858     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.09.025     Document Type: Article

References (29)

1. M.P. Fink Bench-to-bedside review: cytopathic hypoxia Crit. Care 6 2002 491 499
2. M.P. Fink Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis Crit. Care Clin. 17 1 2001 219 237
3. M. Singer, and D. Brealey Mitochondrial dysfunction in sepsis Biochem. Soc. Symp. 66 1999 149 166
4. D. Brealey, M. Brand, I. Hargreaves, S. Heales, J. Land, R. Smolenski, N.A. Davies, C.E. Cooper, and M. Singer Association between mitochondrial dysfunction and severity and outcome of septic shock Lancet 360 9328 2002 219 223
5. D. Nethery, L.A. Callahan, D. Stofan, R. Mattera, A. DiMarco, and G. Supinski PLA(2) dependence of diaphragm mitochondrial formation of reactive oxygen species J. Appl. Physiol. 89 1 2000 72 80
6. I.C. Lang-Rollin, H.J. Rideout, M. Noticewala, and L. Stefanis Mechanisms of caspase-independent neuronal death: energy depletion and free radical generation J. Neurosci. 23 35 2003 11015 11025
7. C. Taille, R. Foresti, S. Lanone, C. Zedda, C. Green, M. Aubier, R. Motterlini, and J. Boczkowski Protective role of heme oxygenases against endotoxin-induced diaphragmatic dysfunction in rats Am. J. Respir. Crit. Care Med. 63 3 Pt 1 2001 753 761
8. L.A. Callahan, and G.S. Supinski Hemin administration prevents sepsis induced mitochondrial alterations Am. J. Respir. Crit. Care Med. 167 2003 A555
9. D.T. Lucas, and L.I. Szweda Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction Proc. Natl. Acad. Sci. USA 95 2 1998 510 514
10. K.M. Humphries, Y. Yoo, and L.I. Szweda Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal Biochemistry 37 2 1998 527 552
11. A.Z. Reznick, and L. Packer Oxidative damage to proteins: spectrophotometric method for carbonyl assay Methods Enzymol. 233 1994 357 363
12. E.A. Meagher, and G.A. FitzGerald Indices of lipid peroxidation in vivo: strengths and limitations Free Radic. Biol. Med. 28 12 2000 1745 1750
13. E. Barreiro, A.S. Comtois, S. Mohammed, L.C. Lands, and S.N. Hussain Role of heme oxygenases in sepsis-induced diaphragmatic contractile dysfunction and oxidative stress Am. J. Physiol. Lung Cell. Mol. Physiol. 283 2 2002 L476 L484
14. S. Sharma, and A. Kumar Septic shock, multiple organ failure, and acute respiratory distress syndrome Curr. Opin. Pulm. Med. 9 3 2003 199 209
15. E.S. Van Amersfoort, T.J. Van Berkel, and J. Kuiper Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock Clin. Microbiol. Rev. 16 3 2003 379 414
16. C. Ince, and M. Sinaasappel Microcirculatory oxygenation and shunting in sepsis and shock Crit. Care Med. 27 1999 1369 1377
17. 18F]fluoroisonidazole Am. J. Physiol. 261 1991 R965 R972
18. R. Zell, P. Geck, K. Werden, and P. Boekstegers TNF-alpha and IL-1alpha inhibit both pyruvate dehydrogenase activity and mitochondrial function in cardiomyocytes: evidence for primary impairment of mitochondrial function Mol. Cell. Biochem. 177 1997 61 67
19. S. Trumbeckaite, J.R. Poalka, C. Neuhof, S. Zierz, and F.N. Gellerich Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function Eur. J. Biochem. 268 2001 1422 1429
20. L.A. Callahan, D. Stofan, L. Szweda, D. Nethery, and G.S. Supinski Free radicals alter maximal diaphragmatic oxygen consumption in endotoxin-induced sepsis Free Radic. Biol. Med. 30 2001 129 138
21. J. Boczkowski, C.L. Lisdero, S. Lanone, A. Samb, C. Carreras, A. Boveris, M. Aubier, and J. Poderoso Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia FASEB J. 13 1999 1637 1647
22. G.S. Supinski, D. Stofan, L.A. Callahan, D. Nethery, A. DiMarco, and L. Szweda Endotoxin-induced sepsis elicits free radical mediated alterations in diaphragm mitochondrial proteins FASEB J. 14 2000 A198
23. G.S. Supinski, and L.A. Callahan Alterations in the mitochondrial electron transport chain in endotoxin-mediated sepsis FASEB J. 15 2001 A1080
24. S.P. Kantrow, D.E. Taylor, M.S. Carraway, and C.A. Piantadosi Oxidative metabolism in rat hepatocytes and mitochondria during sepsis Arch. Biochem. Biophys. 345 2 1997 278 288
25. L.E. Otterbein, M.P. Soares, K. Yamashita, and F.H. Bach Heme oxygenase-1: unleashing the protective properties of heme Trends Immunol. 24 8 2003 449 455
26. B.S. Zuckerbraun, and T.R. Billiar Heme oxygenase-1: a cellular Hercules Hepatology 37 4 2003 742 744
27. S.W. Ryter, L.E. Otterbein, D. Morse, and A.M. Choi Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance Mol. Cell. Biochem. 234-235 1-2 2002 2463 2492
28. 2 alterations induced by endotoxin correlate with severity of mitochondrial injury Am. J. Respir. Crit. Care Med. 160 1999 1347 1353
29. H.B. Suliman, M.S. Carraway, L.W. Velsor, B.J. Day, A.J. Ghioc, and C.A. Piantadosi Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure Free Radic. Biol. Med. 32 2002 246 256