High frequency of Plasmodium falciparum PfCRT K76T and PfpghN86Y in patients clearing infection after chloroquine treatment in the Sudan

Acta Tropica

Volumn 97, Issue 1, 2006, Pages 19-25

  Tagelsir, Nawal ^a,b   Ibrahim, Zeinab ^a   Medani, AbdelRahman ^a   Salih, Omaima ^a   Hamad, Amel ^a   Giha, Haider ^c   El Agib, Atif ^d   Khan, Baldip ^e   Saeed, Najeeb ^a   Ibrahim, Muntaser ^b  

^a National Health Laboratory Sudan   (Sudan)

^b UNIVERSITY OF KHARTOUM   (Sudan)

^c UNIVERSITY OF KHARTOUM   (Sudan)

^d MINISTRY OF SCIENCE AND TECHNOLOGY   (Sudan)

^e INTERNATIONAL ATOMIC ENERGY AGENCY   (Austria)

Author keywords

Chloroquine resistance transporter gene; Malaria; Multi drug resistance gene; Sudan

Indexed keywords

CHLOROQUINE;

DISEASE TREATMENT; DRUG RESISTANCE; MALARIA;

ALLELE; ANTIBIOTIC RESISTANCE; ARTICLE; CLINICAL PROTOCOL; DNA POLYMORPHISM; DRUG SENSITIVITY; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALARIA; MALE; MUTANT; NONHUMAN; PARASITE PREVALENCE; PATIENT; PLASMODIUM FALCIPARUM; SAMPLE; STANDARD; SUDAN; TREATMENT OUTCOME; WORLD HEALTH ORGANIZATION;

ADOLESCENT; ADULT; ANIMALS; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE; FEMALE; HUMANS; MALARIA, FALCIPARUM; MALE; MEMBRANE PROTEINS; P-GLYCOPROTEIN; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; POLYMORPHISM, GENETIC; PROTOZOAN PROTEINS; SUDAN; TREATMENT OUTCOME;

AFRICA; EAST AFRICA; SUB-SAHARAN AFRICA; SUDAN;

PLASMODIUM FALCIPARUM;

EID: 28744440573     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2005.07.030     Document Type: Article

References (25)

1. A.A. Abdel-Muhsin, M.J. Mackinnon, E. Ali, E. Nassir, S. Suleiman, S. Ahmed, D. Walliker, and H.A. Babiker Evolution of drug-resistance genes in Plasmodium falciparum in an area of seasonal malaria transmission in Eastern Sudan J. Infect. Dis. 189 2004 1239 1244
2. I. Adam, I.E. A-Elbasit, I. Salih, and M.I. Elbashir Submicroscopic Plasmodium falciparum infections during pregnancy, in an area of Sudan with a low intensity of malaria transmission Ann. Trop. Med. Parasitol. 99 4 2005 339 344
3. F.M. Awad-El-Kariem, M.A. Miles, and D.C. Warhurst Chloroquine-resistant Plasmodium falciparum isolates from the Sudan lack two mutations in the Pfmdr-1 gene thought to be associated with Chloroquine resistance Trans. R. Soc. Trop. Med. Hyg. 86 1992 587 589
4. H.A. Babiker, S.J. Pringle, A. Abdel-Muhsin, M. Mackinnon, P. Hunt, and D. Walliker High-Level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene Pfcrt and the multidrug resistance gene Pfmdr-1 J. Infect. Dis. 185 2001 405 407
5. L.K. Basco, M. Ndounga, V.F. Ngane, and G. Soula Molecular epidemiology of malaria in Cameroon. XIV. Plasmodium falciparum chloroquine resistance transporter (Pfcrt) gene sequences of isolates before and after chloroquine treatment Am. J. Trop. Med. Hyg. 67 2002 392 395
6. R.A. Bayoumi, H.A. Babiker, S.M. Ibrahim, H.W. Galib, B.O. Saeed, S. Khider, M. El Wasila, and F.M. Awad El Karem Chloroquine resistant Plasmodium falciparum in Eastern Sudan Acta Trop. 46 1989 157 165
7. J.M.R. Carlton, D.A. Fidock, A. Djimde, C.V. Plow, and T.E. Wellems Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of Plasmodium falciparum Curr. Opin. Microbiol. 4 2001 415 420
8. R.A. Cooper, M.T. Ferdig, X.Z. Su, L.M. Ursos, J. Mu, T. Nomura, H. Fujioka, D.A. Fidock, P.D. Roepe, and T.E. Wellems Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum Mol. Pharmacol. 61 2002 35 42
9. R.A. Cooper, C.L. Hartwig, and M.T. Ferdig Pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective Acta Trop. 94 2005 170 180
10. A. Djimde, O.K. Doumbo, J.F. Cortese, K. Kayentao, S. Doumbo, Y. Diourte, A. Dicko, X.Z. Su, D. Fidock, T. Nomura, D.A. Fidock, T.E. Wellems, and C.V. Plowe A molecular marker for chloroquine-resistant falciparum malaria N. Engl. J. Med. 344 2001 257 263
11. A. Djimde, O.K. Doumbo, R.W. Steketee, and C.V. Plowe Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria Lancet 358 2001 890 891
12. A. Djimde, O.K. Doumbo, O. Traore, A.B. Guindo, K. Kayentao, Y. Diourte, S. Niare-Doumbo, D. Coulibaly, A.K. Kone, Y. Cissoko, M. Tekete, B. Fofana, A. Dicko, D.A. Diallo, T.E. Wellems, D. Kwiatkowski, and C.V. Plowe Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria Am. J. Trop. Med. Hyg. 69 2003 558 563
13. G. Dorsey, M.R. Kamya, A. Singh, and P.J. Rosenthal Polymorphisms in the Plasmodium falciparum Pfcrt and Pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda J. Infect. Dis. 183 2001 1417 1420
14. M.T. Duraisingh, and A.F. Cowman Contribution of the pfmdr1 gene to antimalarial drug-resistance Acta Trop. 94 2005 181 190
15. D.A. Fidock, T. Nomura, A.T. Talley, R. Cooper, S.M. Dzekunov, M.T. Ferdig, L.M. Ursos, A.B. Sidhu, B. Naude, K.W. Deitsch, X.Z. Su, J.C. Wootton, P.D. Roepe, and T.E. Wellems Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance Mol. Cell. 6 2000 861 871
16. S.J. Foote, D.E. Kyle, R.K. Martin, A.M. Oduola, K. Forsyth, D.J. Kemp, and A.F. Cowman Several alleles of the multi drug resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum Nature 345 1990 255 258
17. T. Jelinek, A.O. Aida, G. Peyerl-Hoffmann, S. Jordan, A. Mayor, C. Heuschkel, A.O. El Valy, F. Von Sonnenburg, and E.M. Christophel Diagnostic value of molecular markers in chloroquine-resistant falciparum malaria in Southern Mauritania Am. J. Trop. Med. Hyg. 67 2002 449 453
18. A.G. Mayor, X. Gomez-Olive, J.J. Aponte, S. Casimiro, S. Mabunda, M. Dgedge, A. Barreto, and P.L. Alonso Prevalence of the K76T mutation in the putative Plasmodium falciparum chloroquine resistance transporter (Pfcrt) gene and its relation to the chloroquine resistance in Mozambique J. Infect. Dis. 183 2001 1413 1416
19. E.O. Ochong, I.V. Van den Broek, K. Keus, and A. Nzila Association between chloroquine and amodiaquine resistance and allelic variation in the Plasmodium falciparum multiple drug resistance 1 gene and the chloroquine resistance transporter gene in isolates from the Upper Nile in southern Sudan Am. J. Trop. Med. Hyg. 69 2003 184 187
20. D.R. Pillai, A.C. Labbe, V. Vanisaveth, B. Hongvangthong, S. Ppmphida, S. Inkathone, K. Zhong, and K.C. Kain Palsmodium falciparum malaria in Laos: chloroquine treatment outcome and predictive value of molecular markers J. Infect. Dis. 183 2001 789 795
21. C.V. Plowe, A. Djimde, M. Bouare, O. Doumbo, and T.E. Wellems Pyrimethamine and proguanil resistance conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa Am. J. Trop. Med. Hyg. 52 1995 565 568
22. M.B. Reed, K.J. Saliba, S.R. Caruana, K. Kirk, and A.F. Cowman Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum Nature 403 2000 906 909
23. S. Vinayak, S. Biswas, V. Dev, A. Kumar, M.A. Ansari, and Y.D. Sharma Prevalence of the K76T mutation in the Pfcrt gene of Plasmodium falciparum among chloroquine responders in India Acta Trop. 87 2003 287 293
24. J.C. Wootton, X. Feng, M.T. Ferdig, R.A. Cooper, J. Mu, D.I. Baruch, A.J. Magill, and X. Su Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum Nature 418 2002 320 323
25. World Heath Organization, 1996. Assessment of the therapeutic efficacy of antimalarial drugs for uncomplicated falciparum malaria for areas of intense transmission (WHO/MAL/96.1077). WHO, Geneva, Switzerland.