Biodegradable microspheres alone do not stimulate murine macrophages in vitro, but prolong antigen presentation by macrophages in vitro and stimulate a solid immune response in mice

Journal of Controlled Release

Volumn 109, Issue 1-3, 2005, Pages 62-76

  Luzardo Alvarez, Asteria ^a,d   Blarer, Natalia ^a   Peter, Katrin ^a,b   Romero, Jackeline F ^b   Reymond, Christophe ^c   Corradin, Giampietro ^b   Gander, Bruno ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c RMF Dictagene SA   (Switzerland)

^d UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Antigen delivery; Antigen presentation; Chitosan microspheres; Macrophage activation; Macrophages; PLGA microspheres

Indexed keywords

ANTIGENS; BIOSYNTHESIS; BONE; CELLS; CHEMICAL ACTIVATION; CROSSLINKING; DISEASES; IMMUNOLOGY; NITROGEN OXIDES; VACCINES;

ANTIGEN DELIVERY; ANTIGEN PRESENTATION; CHITOSAN MICROSPHERES; MACROPHAGE ACTIVATION; MACROPHAGES; PLGA MICROSPHERES;

BIODEGRADATION;

ANTIGEN; CD86 ANTIGEN; CHITOSAN; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MICROSPHERE; MONTANIDE ISA720; NITRIC OXIDE; POLYGLACTIN; PROTOZOAL PROTEIN; REACTIVE OXYGEN METABOLITE; RESOMER; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; BIODEGRADABILITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG TOLERABILITY; DRUG UPTAKE; FEMALE; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VITRO STUDY; INTERNALIZATION; MACROPHAGE ACTIVATION; MICROENCAPSULATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, PROTOZOAN; CELLS, CULTURED; CYCLOOXYGENASE 2; DRUG COMPOUNDING; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENES, MHC CLASS I; GENES, MHC CLASS II; LACTIC ACID; MACROPHAGES; MICE; MICE, INBRED BALB C; MICROSPHERES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHAGOCYTOSIS; PLASMODIUM FALCIPARUM; POLYGLYCOLIC ACID; POLYMERS; RESPIRATORY BURST; SPECTROMETRY, FLUORESCENCE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 28444493985     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.09.015     Document Type: Conference Paper

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