Effects of aspirin and Helicobacter pylori on the gastroduodenal mucosal permeability to sucrose

Gut

Volumn 39, Issue 2, 1996, Pages 159-163

  Rabassa, A A ^a   Goodgame, R ^a   Sutton, F M ^a   Ou, C N ^a,c   Rognerud, C ^a,c   Graham, D Y ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c Texas Children's Hospital   (United States)

Author keywords

Aspirin; Gastric permeability; Helicobacter pylori; Intestinal permeability; Non steroidal inflammatory drugs; Sucrose permeability

Indexed keywords

ACETYLSALICYLIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; SUCROSE;

ADULT; ARTICLE; BACTERIAL INFECTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL TOXICITY; GASTROINTESTINAL TRACT FUNCTION; HELICOBACTER PYLORI; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTESTINE MUCOSA PERMEABILITY; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PERMEABILITY; PRIORITY JOURNAL; STOMACH INJURY; VOLUNTEER;

EID: 0029815921     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.39.2.159     Document Type: Article

References (17)

1. Fries JF, Miller SR, Spitz PW, Williams CA, Hubert HB, Bloch DA. Toward an epidemiology of gastropathy associated with nonsteroidal antiinflammatory drug use. Gastroenterology 1989; 96: 647-55.
2. Armstrong CP, Blower AL. Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration. Gut 1987; 28: 527-32.
3. Meddings JB, Sutherland LR, Byles NI, Wallace JL. Sucrose: a novel permeability marker for gastroduodenal disease. Gastroenterology 1993; 104: 1619-26.
4. Smith BM, Skillman JJ, Edwards BG, Silen W. Permeability of the human gastric mucosa: alteration by acetylsalicylic acid and ethanol. N Engl J Med 1971; 285: 716-21.
5. Ivey KJ, Morrison S, Gray C. Effect of salicylates on the gastric mucosal barrier in man. J Appl Physiol 1972; 33: 81-5.
6. Murray HS, Strottman MP, Cooke AR. Effect of several drugs on gastric potential difference in man. BMJ 1974; i: 19-21.
7. Cooke AR. The role of the mucosal barrier in drug-induced gastric ulceration and erosions. Am J Dig Dis 1976; 21: 155-64.
8. Stern AI, Hogan DL, Isenberg JI. A new method for quantitation of ion fluxes across in vivo human gastric mucosa; effect of aspirin, acetomenophen, ethanol, and hyperosmolar solutions. Gastroenterology 1984; 86: 60-70.
9. Graham DY, Smith JL, Dobbs SM. Gastric adaptation occurs with aspirin administration in man. Dig Dis Sci 1983; 28: 1-6.
10. Graham DY, Smith JL, Spjut HJ, Torres E. Gastric adaptation: studies in humans during continuous aspirin administration. Gastroenterology 1988; 95: 327-33.
11. Graham DY, Smith JL. Aspirin and the stomach. Ann Intern Med 1986; 104: 390-8.
12. Graham DY, Lidsky MD, Cox AM, Evans DJ, Evans DG, Alpert L, et al. Long-term nonsteroidal antiinflammatory drug use and Helicobacter pylori infection. Gastroenterology 1991; 100: 1653-7.
13. Lanza F, Evans DG, Graham DY. Effect of Helicobacter pylori infection on the severity of gastroduodenal mucosal injury after the acute administration of naproxen or aspirin to normal volunteers. Am J Gastroenterol 1991; 86: 735-7.
14. Loeb DS, Talley NJ, Ahlquist DA, Carpenter HA, Zinmeister AR. Long-term nonsteroidal antiinflammatory drug use and gastroduodenal injury: the role of Helicobacter pylori. Gastroenterology 1992; 102: 1899-905.
15. Thillainayagam AV, Tabaqchali S, Warrington SJ, Farthing MJG. Inerrelationships between Helicobacter pylori infection, nonsteroidal antiinflammatory drugs and gastroduodenal disease: a prospective study in healthy volunteers. Dig Dis Sci 1994; 39: 1085-9.
16. Peterson WL, Lee E, Feldman M. Relationship between Campylobacter pylori and gastritis in healthy humans after administration of placebo or indomethacin. Gastroenterology 1988; 95: 1185-97.
17. Sutherland LR, Verhoef M, Wallace JL, Van Rosendaal G, Crutcher R, Meddings JB. A simple, noninvasive marker of gastric damage: sucrose permeability. Lancet 1994; 343: 998-1000.