Solution structure of a common substrate mimetic of cyclooxygenase- downstream synthases bound to an engineered thromboxane A2 synthase using a high-resolution NMR technique

Archives of Biochemistry and Biophysics

Volumn 444, Issue 2, 2005, Pages 165-173

  Ruan, Ke He ^a   Wu, Jiaxin ^a   Wang, Lee Ho ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

NMR; Prostaglandin H2; Solution structure; Thromboxane A2 synthase; U44069

Indexed keywords

15 HYDROXY 9ALPHA,11ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; PROSTAGLANDIN H2; PROSTAGLANDIN SYNTHASE; PROSTANOID; THROMBOXANE SYNTHASE;

ARTICLE; CALCULATION; CONFORMATIONAL TRANSITION; ENZYME SUBSTRATE; ISOMERIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; STRUCTURE ANALYSIS; TITRIMETRY;

BINDING SITES; BIOMIMETIC MATERIALS; COMPUTER SIMULATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC; PROSTAGLANDIN H2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SOLUTIONS; SUBSTRATE SPECIFICITY; THROMBOXANE-A SYNTHASE;

EID: 28444473094     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2005.10.010     Document Type: Article

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