Identification of thromboxane A2 synthase active site residues by molecular modeling-guided site-directed mutagenesis

Journal of Biological Chemistry

Volumn 271, Issue 33, 1996, Pages 19970-19975

  Wang, Lee Ho ^a   Matijevic Aleksic, Nena ^a   Hsu, Pei Yung ^a   Ruan, Ke He ^a   Wu, Kenneth K ^a   Kulmacz, Richard J ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBOXANE SYNTHASE; CYTOCHROME P450; PRIMER DNA; PROSTAGLANDIN H; PROSTAGLANDIN H2;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; ANIMAL; BINDING SITE; CELL LINE; CERCOPITHECUS; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; HUMAN; KINETICS; METABOLISM; MICROSOME; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; CERCOPITHECUS AETHIOPS; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; HUMANS; KINETICS; MICROSOMES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROSTAGLANDIN H2; PROSTAGLANDINS H; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOXANE-A SYNTHASE;

EID: 0029664951     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.33.19970     Document Type: Article

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