Defective natural killer cell function in patients with hemophagocytic lymphohistiocytosis and in first degree relatives

Pediatric Research

Volumn 44, Issue 4, 1998, Pages 465-468

  Sullivan, Kathleen E ^a   Delaat, Cynthia A ^b   Douglas, Steven D ^a   Filipovich, Alexandra H ^b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CASE REPORT; CELL FUNCTION; CELL PROLIFERATION; CHILD; EARLY DIAGNOSIS; ERYTHROPHAGOCYTOSIS; FAMILIAL DISEASE; GENETIC PREDISPOSITION; HEMOPHAGOCYTIC SYNDROME; HISTIOCYTOSIS; HUMAN; KILLER CELL; MALE; PRIORITY JOURNAL; RELIABILITY; SIBLING; T LYMPHOCYTE ACTIVATION;

EID: 0031670358     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199810000-00001     Document Type: Article

References (28)

1. Janka GE 1983 Familial crythrophagocytic lymphohistiocytosis. Eur J Pediatr 140:221-230
2. Hirst WJR, Layton DM, Singh S, Mieli-Vergani G, Chessells JM 1994 Haemophagocytic lymphohistiocytosis: experience at two U.K. centres. Br J Haematol 88:731-739
3. Stark B, Hershko C, Rosen N, Cividalli G, Karsai H, Soffer D 1984 Familial hemophagocytic lymphohistiocytosis (FHLH) in Israel. Cancer 54:2109-2121
4. Fischer A, Virelizier JL, Arenzana-Seisdedos F, Perez N, Nezelof C, Griscelli C 1985 Treatment of four patients with erythrophagocytic lymphohistiocytosis by a combination of epidophyllotoxin, steroids, intrathecal methotrexate, and cranial irradiation. Pediatrics 76:263-268
5. Reiner A, Spivak JL 1988 Hemophagocytic histiocytosis. Medicine 67:369-388
6. Chu T, D'Angio GJ, Favara B, Ladisch S, Nesbit M, Pritchard J 1987 Histiocytosis syndromes in children. Lancet 2:41-42
7. Bejaoui M, Veber F, Girault C, Gaud C, Blanche S, Griscelli C, Fischer A 1989 Phase acceleree de la maladie de Chediak-Higashi. Arch Fr Pediatr 46:733-736
8. Grierson H, Purtilo DT 1987 Epstein-Barr virus infections in males with the X-linked lymphproliferative syndrome. Ann Intern Med 106:538-545
9. Roder JC, Haliotis T, Klein M, Korec S, Jett JR, Ortaldo J, Heberman RB, Katz P, Fauci AS 1980 A new immunodeficiency disorder in humans involving NK cells. Nature 284:553-555
10. Parenti G, Sebastio G, Strisciuglio P, Incerti B, Pecoraro C, Terracciano L, Andria G 1995 Lysinuric protein intolerance characterized by bone marrow abnormalities and severe clinical course. J Pediatr 126:246-251
11. Gogus S, Topcu M, Kucukali T, Akcoren Z, Berkel I, Gunay M, Saatci I 1995 Griscelli syndrome: report of three cases. Pediatr Pathol Lab Med 15:309-319
12. Henter J-I, Elinder G, Ost A 1991 Diagnostic guidelines for hemophagocytic lymphohistiocytosis. Semin Oncol 18:29-33
13. Kataoka Y, Todo S, Morioka Y, Sugie K, Nakamura Y, Yodoi J, Imashuku S 1990 Impaired natural killer activity and expression of interleukin-2 receptor antigen in familial erythrophagocytic lymphohistiocytosis. Cancer 65:1937-1941
14. Stark B, Cohen IJ, Pecht M, Umiel T, Apte RN, Friedman E, Levin S, Vogel R, Schlesinger M, Zaizov R 1987 Immunologic dysregulation in a patient with familial hemophagocytic lymphohistiocytosis. Cancer 60:2629-2636
15. Eife R, Janka GE, Belohradsky BH, Holtmann H 1989 Natural killer cell function and interferon production in familial hemophagocytic lymphohistiocytosis. Pediatr Hematol Oncol 6:265-272
16. Arico M, Nespoli L, Maccario R, Montagna D, Bonetti F, Caselli D, Burgio GR 1988 Natural cytotoxicity impairment in familial haemophagocytic lymphohistiocytosis. Arch Dis Child 63:292-296
17. Perez N, Virelizier JL, Arenzana-Seisdedos F, Fischer A, Griscelli C 1984 Impaired natural killer activity in lymphohistiocytosis syndrome. J Pediatr 104:569-573
18. Egeler RM, Shapiro R, Loechelt B, Filipovitch AH 1996 Characteristic immune abnormalities in hemophagocytic lymphohistiocytosis. J Pediatr Hematol Oncol 18:340-345
19. Baker KS, DeLaat C, A, Steinbuch M, Gross TG, Shapiro RS, Loechelt B, Harris R, Filipovich AH 1997 Successful correction of hemophagocytic lymphohistiocytosis with related or unrelated bone marrow transplantation. Blood 89:3857-3863
20. Arico M, Janka G, Fischer A, Henter JI, Blanche S, Blinder G, Martinetti M, Rusca MP 1996 Hemophagocytic lymphohistiocytosis. Report of 122 children from the international registry. FLH study group of the histiocyte society. Leukemia 10:197-203
21. Osugi Y, Hara J, Tagawa S, Takai K, Hosoi G, Matsuda Y, Ohta H, Fujisaki H, Kobayashi M, Sakata N, Kawa-Ha K, Okada S, Tawa A 1997 Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis. Blood 89:4100-4103
22. Lay J-D, Tsao C-J, Chen J-Y, Kadin ME, Su I-J 1997 Upregulation of tumor necrosis factor-a gene by Epstein-Barr virus and activation of macrophages in Epstein-Barr virus infected T cells in the pathogenesis of hemophagocytic syndrome. J Clin Invest 100:1969-1979
23. Kawaguchi H, Miyashita T, Herbst H, Niedobitek G, Asada M, Tsuchida M, Hanada R, Kinoshita A, Sakurai M, Kobayashi N, Mizutani S 1993 Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome. J Clin Invest 92:1444-1450
24. McClain K, Gehrz R, Grierson H, Purtilo D, Filipovich AH 1988 Virus-associated histiocytic proliferations in children. Frequent association with Epstein-Barr virus and congenital or acquired immunodeficiencies. Am J Pediatr Hematol Oncol 10:196-205
25. Kobayashi Y, Uehara S, Inamori K, Shirato R, Ozawa K, Sklar J, Asano S 1996 Hemophagocytosis as a paraneoplastic syndrome in NK cell leukemia. Int J Hematol 64:135-142
26. Henter JI, Elinder G, Soder O, Hansson M, Andersson B, Andersson U 1991 Hypercytokinemia in familial hemophagocytic lymphohistiocytosis. Blood 78:2918-2922
27. Drappa J, Vaishnaw AK, Sullivan KE, Chu J-L, Elkon KB 1996 Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J Med 335:1643-1649
28. Schneider EM, Harms B, Lorenz I, Stoldt V, Janka-Schaub GE 1996 Interferon-γ (IFN-γ) and interleukin 10 double positive T cells as potent activators of an uncontrolled hyperinflammatory response in patients with familial and infection-associated histiocytosis. Proceedings of the Histiocyte Society, Vienna, Astria