-
1
-
-
0027745255
-
Hypouricemic effect of allopurinol and the novel xanthine oxidase inhibitor TEI-6720 in chimpanzees
-
172279
-
172279 Hypouricemic effect of allopurinol and the novel xanthine oxidase inhibitor TEI-6720 in chimpanzees. Komoriya K, Osada Y, Hasegawa M, Horiuchi H, Kondo S, Couch RC, Griffin TB EUR J PHARMACOL 1993 250 3 455-460
-
(1993)
Eur. J. Pharmacol.
, vol.250
, Issue.3
, pp. 455-460
-
-
Komoriya, K.1
Osada, Y.2
Hasegawa, M.3
Horiuchi, H.4
Kondo, S.5
Couch, R.C.6
Griffin, T.B.7
-
2
-
-
0027205542
-
Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents
-
172281
-
172281 Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Osada Y, Tsuchimoto M, Fukushima H, Takahashi K, Kondo S, Hasegawa M, Komoriya K EUR J PHARMACOL 1993 241 2-3 183-188
-
(1993)
Eur. J. Pharmacol.
, vol.241
, Issue.2-3
, pp. 183-188
-
-
Osada, Y.1
Tsuchimoto, M.2
Fukushima, H.3
Takahashi, K.4
Kondo, S.5
Hasegawa, M.6
Komoriya, K.7
-
3
-
-
28244465150
-
Drug development pipeline: TEI-6720 and TEI-6469
-
343275 Teijin Ltd COMPANY COMMUNICATION October 13
-
343275 Drug development pipeline: TEI-6720 and TEI-6469. Teijin Ltd COMPANY COMMUNICATION 1999 October 13
-
(1999)
-
-
-
4
-
-
28244463363
-
Teijin licenses TMX-67, gout treatment, to TAP Holdings
-
343974
-
343974 Teijin licenses TMX-67, gout treatment, to TAP Holdings. PHARMA JAPAN 1999 1668 10
-
(1999)
Pharma. Japan
, vol.1668
, pp. 10
-
-
-
5
-
-
0005828342
-
Hypouricemic activity of a novel xanthine oxidase/xanthine dehydrogenase (XOD/XDH) inhibitor, TEI-6720 in rats
-
365106
-
365106 Hypouricemic activity of a novel xanthine oxidase/xanthine dehydrogenase (XOD/XDH) inhibitor, TEI-6720 in rats. Horiuchi H, Ota M, Kobasyashi M, Kaneko H, Kasahara Y, Nishimura S, Kondo S, Komoriya K JPN J PHARMACOL 2000 82 1 P-606
-
(2000)
Jpn. J. Pharmacol.
, vol.82
, Issue.1
-
-
Horiuchi, H.1
Ota, M.2
Kobasyashi, M.3
Kaneko, H.4
Kasahara, Y.5
Nishimura, S.6
Kondo, S.7
Komoriya, K.8
-
6
-
-
0034646735
-
Allopurinol induces renal toxicity by impairing pyrimidine metabolism in mice
-
379985
-
379985 Allopurinol induces renal toxicity by impairing pyrimidine metabolism in mice. Horiuchi H, Ota M, Nishimura S, Kaneko H, Kasahara Y, Ohta T, Komoriya K LIFE SCI 2000 66 21 2051-2070
-
(2000)
Life Sci.
, vol.66
, Issue.21
, pp. 2051-2070
-
-
Horiuchi, H.1
Ota, M.2
Nishimura, S.3
Kaneko, H.4
Kasahara, Y.5
Ohta, T.6
Komoriya, K.7
-
7
-
-
0033985499
-
Effect of TEI-6720, a xanthine oxidase inhibitor, on the nucleoside transport in the lung cancer cell line A549
-
379987
-
379987 Effect of TEI-6720, a xanthine oxidase inhibitor, on the nucleoside transport in the lung cancer cell line A549. Yamamoto T, Moriwaki Y, Fujimura Y, Takahashi S, Tsutsumi Z, Tsutsui T, Higashino K, Hada T PHARMACOLOGY 2000 60 1 34-40
-
(2000)
Pharmacology
, vol.60
, Issue.1
, pp. 34-40
-
-
Yamamoto, T.1
Moriwaki, Y.2
Fujimura, Y.3
Takahashi, S.4
Tsutsumi, Z.5
Tsutsui, T.6
Higashino, K.7
Hada, T.8
-
8
-
-
0032832552
-
Allopurinol increases ear swelling and mortality in a dinitrofluorobenzene-induced contact hypersensitivity mouse model
-
379988
-
379988 Allopurinol increases ear swelling and mortality in a dinitrofluorobenzene-induced contact hypersensitivity mouse model. Horiuchi H, Ota M, Kitahara S, Ohta T, Kiyoki M, Komoriya K BIOL PHARM BULL 1999 22 8 810-815
-
(1999)
Biol. Pharm. Bull.
, vol.22
, Issue.8
, pp. 810-815
-
-
Horiuchi, H.1
Ota, M.2
Kitahara, S.3
Ohta, T.4
Kiyoki, M.5
Komoriya, K.6
-
9
-
-
0033511044
-
A comparative study on the hypouricemic activity and potency in renal xanthine calculus formation of two xanthine oxidase/xanthine dehydrogenase inhibitors: TEI-6720 and allopurinol in rats
-
379989
-
379989 A comparative study on the hypouricemic activity and potency in renal xanthine calculus formation of two xanthine oxidase/xanthine dehydrogenase inhibitors: TEI-6720 and allopurinol in rats. Horiuchi H, Ota M, Kobayashi M, Kaneko H, Kasahara Y, Nishimura S, Kondo S, Komoriya K RES COMM MOL PATHOL PHARMACOL 1999 104 3 307-319
-
(1999)
Res. Comm. Mol. Pathol. Pharmacol.
, vol.104
, Issue.3
, pp. 307-319
-
-
Horiuchi, H.1
Ota, M.2
Kobayashi, M.3
Kaneko, H.4
Kasahara, Y.5
Nishimura, S.6
Kondo, S.7
Komoriya, K.8
-
10
-
-
0033501993
-
Nephrotoxic effects of allopurinol in dinitrofluorobenzenesensitized mice: Comparative studies on TEI-6720
-
379991
-
379991 Nephrotoxic effects of allopurinol in dinitrofluorobenzenesensitized mice: Comparative studies on TEI-6720. Horiuchi H, Ota M, Kaneko H, Kasahara Y, Ohta T, Komoriya K RES COMM MOL PATHOL PHARMACOL 1999 104 3 293-305
-
(1999)
Res. Comm. Mol. Pathol. Pharmacol.
, vol.104
, Issue.3
, pp. 293-305
-
-
Horiuchi, H.1
Ota, M.2
Kaneko, H.3
Kasahara, Y.4
Ohta, T.5
Komoriya, K.6
-
11
-
-
28244462193
-
BioPartnering - TAP Pharmaceuticals Inc
-
388243 October 16-17
-
388243 BioPartnering - TAP Pharmaceuticals Inc. ANNU BIOPARTNERING EUROPE MEET 2000 8 October 16-17
-
(2000)
Annu. Biopartnering Europe Meet.
, pp. 8
-
-
-
12
-
-
0008643128
-
Drug development pipeline - Abbott Laboratories. From a presentation by Miles D White CEO of Abbott at the Merrill Lynch Global Healthcare Conference, February 6-8, 2001
-
398274 Abbott Laboratories. COMPANY WORLD WIDE WEB SITE February 08
-
398274 Drug development pipeline - Abbott Laboratories. From a presentation by Miles D White CEO of Abbott at the Merrill Lynch Global Healthcare Conference, February 6-8, 2001. Abbott Laboratories. COMPANY WORLD WIDE WEB SITE 2001 February 08
-
(2001)
-
-
-
13
-
-
20344367126
-
Abbott Laboratories: Credit Suisse First Boston Health Care Conference
-
429705 Abbott Laboratories COMPANY REPRESENTATION November 14
-
429705 Abbott Laboratories: Credit Suisse First Boston Health Care Conference. Abbott Laboratories COMPANY PRESENTATION 2001 November 14
-
(2001)
-
-
-
14
-
-
28244477678
-
Teijin aims at ¥200 billion drug sales via M&As, JV
-
462792 August 26
-
462792 Teijin aims at ¥200 billion drug sales via M&As, JV. PHARMA JPN 2002 1808 August 26
-
(2002)
Pharma. Jpn.
, vol.1808
-
-
-
15
-
-
28244440587
-
-
470328 American College of Rheumatology - 66th Annual Scientific Meeting, New Orleans, LA, USA IDDB MEETING REPORT October
-
470328 American College of Rheumatology - 66th Annual Scientific Meeting, New Orleans, LA, USA. Sylvester B IDDB MEETING REPORT 2002 October 25-29
-
(2002)
, pp. 25-29
-
-
Sylvester, B.1
-
16
-
-
28244456778
-
Phase II, dose-response, safety and efficacy clinical trial of a new oral xanthine oxidase inhibitor TMX-67 (febuxostat) in subjects with gout
-
478775 October Abs 289
-
478775 Phase II, dose-response, safety and efficacy clinical trial of a new oral xanthine oxidase inhibitor TMX-67 (febuxostat) in subjects with gout. Joseph-Ridge N AM COLL RHEUMATOL 2002 October 25-29 Abs 289
-
(2002)
Am. Coll. Rheumatol.
, pp. 25-29
-
-
Joseph-Ridge, N.1
-
17
-
-
20344392511
-
Abbott Laboratories - 2003 R&D update
-
491208 Abbott Laboratories COMPANY PRESENTATION May 29
-
491208 Abbott Laboratories - 2003 R&D update. Abbott Laboratories COMPANY PRESENTATION 2003 May 29
-
(2003)
-
-
-
18
-
-
28244442921
-
Agreement between Teijin Limited and Ipsen for the development and the marketing of four Ipsen products in Japan and a new agent discovered by Teijin Limited in Europe
-
496132 Teijin Ltd PRESS RELEASE July 07
-
496132 Agreement between Teijin Limited and Ipsen for the development and the marketing of four Ipsen products in Japan and a new agent discovered by Teijin Limited in Europe. Teijin Ltd PRESS RELEASE 2003 July 07
-
(2003)
-
-
-
19
-
-
0037449776
-
An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition
-
497926
-
497926 An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. Okamoto K, Eger BT, Nishino T, Kondo S, Pai EF, Nishino T J BIOL CHEM 2003 278 3 1848-1855
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.3
, pp. 1848-1855
-
-
Okamoto, K.1
Eger, B.T.2
Nishino, T.3
Kondo, S.4
Pai, E.F.5
Nishino, T.6
-
20
-
-
28244446755
-
EULAR 2004 - Annual European Rheumatology Congress, Berlin, Germany
-
546527 IDDB MEETING REPORT June
-
546527 EULAR 2004 - Annual European Rheumatology Congress, Berlin, Germany. Erlandsson Harris H IDDB MEETING REPORT 2004 June 9-12
-
(2004)
, pp. 9-12
-
-
Erlandsson Harris, H.1
-
21
-
-
4043147462
-
Phase II dose-response clinical trial using febuxostat (TMX-67), a novel-type xanthine oxidase/xanthine dehydrogenase inhibitor, for gout and hyperuricemia
-
548190
-
548190 Phase II dose-response clinical trial using febuxostat (TMX-67), a novel-type xanthine oxidase/xanthine dehydrogenase inhibitor, for gout and hyperuricemia. Kamatani N, Fujimori S, Hada T, Hosoya T, Kato R, Matsuzawa Y, Ueda T ARTHRITIS RHEUM 2008 48 9 Suppl S530
-
(2008)
Arthritis Rheum.
, vol.48
, Issue.9 SUPPL.
-
-
Kamatani, N.1
Fujimori, S.2
Hada, T.3
Hosoya, T.4
Kato, R.5
Matsuzawa, Y.6
Ueda, T.7
-
22
-
-
8344287329
-
Effect of renal impairment on pharmacokinetics, pharmacodynamics, and safety of febuxostat (TMX-67), a novel non-purine selective inhibitor of xanthine oxidase
-
548192 MMD
-
548192 Effect of renal impairment on pharmacokinetics, pharmacodynamics, and safety of febuxostat (TMX-67), a novel non-purine selective inhibitor of xanthine oxidase. Swan S, Khosravan R MMD, Wu JT, Palo WA, MacDonald PA, Vernillet L, Joseph RN ARTHRITIS RHEUM 2003 48 9 Suppl S529
-
(2003)
Arthritis Rheum.
, vol.48
, Issue.9 SUPPL.
-
-
Swan, S.1
Khosravan, R.2
Wu, J.T.3
Palo, W.A.4
MacDonald, P.A.5
Vernillet, L.6
Joseph, R.N.7
-
23
-
-
14944352615
-
Effect of febuxostat, a novel non-purine, selective inhibitor of xanthine oxidase (NP-SIXO), on enzymes in purine and pyrimidine metabolism pathway
-
548193
-
548193 Effect of febuxostat, a novel non-purine, selective inhibitor of xanthine oxidase (NP-SIXO), on enzymes in purine and pyrimidine metabolism pathway. Zhao L, Takano Y, Horiuchi H ARTHRITIS RHEUM 2003 48 9 Suppl S351
-
(2003)
Arthritis Rheum.
, vol.48
, Issue.9 SUPPL.
-
-
Zhao, L.1
Takano, Y.2
Horiuchi, H.3
-
24
-
-
28244474967
-
Result of 1Q and Outlook for FY04
-
552291 Teijin Ltd COMPANY REPRESENTATION August 03
-
552291 Result of 1Q and Outlook for FY04. Teijin Ltd COMPANY PRESENTATION 2004 August 03
-
(2004)
-
-
-
25
-
-
28244463362
-
Consolidated Financial Results for the First Quarter of FY2004
-
552419 Teijin Ltd PRESS RELEASE August 03
-
552419 Consolidated Financial Results for the First Quarter of FY2004. Teijin Ltd PRESS RELEASE 2004 August 03
-
(2004)
-
-
-
26
-
-
28244456568
-
Data Presented at American College of Rheumatology Meeting on Febuxostat, an Investigational Therapy for Hyperuricemia Associated With Gout
-
565234 TAP Pharmaceutical Products Inc PRESS RELEASE October 19
-
565234 Data Presented at American College of Rheumatology Meeting on Febuxostat, an Investigational Therapy for Hyperuricemia Associated With Gout. TAP Pharmaceutical Products Inc PRESS RELEASE 2004 October 19
-
(2004)
-
-
-
27
-
-
28244496235
-
TAP's febuxostat superior to allopurinol for gout
-
565235 TAP Pharmaceutical Products Inc PRESS RELEASE October 19
-
565235 TAP's febuxostat superior to allopurinol for gout. TAP Pharmaceutical Products Inc PRESS RELEASE 2004 October 19
-
(2004)
-
-
-
28
-
-
22744438570
-
Febuxostat, a non-purine selective inhibitor of xanthine oxidase - Effect of mild and moderate hepatic impairment on pharmacokinetics, pharmacodynamics, and safety
-
565461 806/186
-
565461 Febuxostat, a non-purine selective inhibitor of xanthine oxidase - effect of mild and moderate hepatic impairment on pharmacokinetics, pharmacodynamics, and safety. Khosravan R, Mayer M, Grabowski B, Vernillet L, Wu JT, Joseph-Ridge N ARTHRITIS RHEUM 2004 50 Suppl 9 806/186
-
(2004)
Arthritis Rheum.
, vol.50
, Issue.SUPPL. 9
-
-
Khosravan, R.1
Mayer, M.2
Grabowski, B.3
Vernillet, L.4
Wu, J.T.5
Joseph-Ridge, N.6
-
29
-
-
18144406652
-
A phase 2, long term open-label safety and efficacy study of febuxostat, a novel non-purine, selective inhibitor of xanthine oxidase
-
565465 800/180
-
565465 A phase 2, long term open-label safety and efficacy study of febuxostat, a novel non-purine, selective inhibitor of xanthine oxidase. Schumacher HR, Wortmann R, Becker MA, MacDonald P, Palo WA, Eustace D, Streit J, Joseph-Ridge N ARTHRITIS RHEUM 2004 50 Suppl 9 800/180
-
(2004)
Arthritis Rheum.
, vol.50
, Issue.SUPPL. 9
-
-
Schumacher, H.R.1
Wortmann, R.2
Becker, M.A.3
MacDonald, P.4
Palo, W.A.5
Eustace, D.6
Streit, J.7
Joseph-Ridge, N.8
-
30
-
-
18144370169
-
Febuxostat, a novel non-purine selective inhibitor of xanthine oxidase, therapy in allopurinol intolerant patients
-
565467 800/103
-
565467 Febuxostat, a novel non-purine selective inhibitor of xanthine oxidase, therapy in allopurinol intolerant patients. Becker MA, Schumacher R, Wortmann R, MacDonald P, Palo W, Joseph-Ridge N ARTHRITIS RHEUM 2004 50 Suppl 9 800/103
-
(2004)
Arthritis Rheum.
, vol.50
, Issue.SUPPL. 9
-
-
Becker, M.A.1
Schumacher, R.2
Wortmann, R.3
MacDonald, P.4
Palo, W.5
Joseph-Ridge, N.6
-
31
-
-
28244500064
-
TAP files oral febuxostat NDA for gout
-
576209 TAP Pharmaceutical Products Inc PRESS RELEASE December 15
-
576209 TAP files oral febuxostat NDA for gout. TAP Pharmaceutical Products Inc PRESS RELEASE 2004 December 15
-
(2004)
-
-
-
32
-
-
28244451977
-
TAP submits NDA for febuxostat for hyperuricemia in chronic gout
-
579485
-
579485 TAP submits NDA for febuxostat for hyperuricemia in chronic gout. PHARMA JPN 2004 1924 7
-
(2004)
Pharma. Jpn.
, vol.1924
, pp. 7
-
-
-
33
-
-
10344222996
-
Pharmacokinetics and pharmacodynamics of febuxostat (TMX-67), a non-purine selective inhibitor of xanthine oxidase/xanthine dehydrogenase (NPSIXO) in patients with gout and/or hyperuricemia
-
579816
-
579816 Pharmacokinetics and pharmacodynamics of febuxostat (TMX-67), a non-purine selective inhibitor of xanthine oxidase/xanthine dehydrogenase (NPSIXO) in patients with gout and/or hyperuricemia. Komoriya K, Hoshide S, Takeda K, Kobayashi H, Kubo J, Tsuchimoto M, Nakachi T, Yamanaka H, Kamatani N NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS 2004 23 8-9 1119-1122
-
(2004)
Nucleosides Nucleotides Nucleic Acids
, vol.23
, Issue.8-9
, pp. 1119-1122
-
-
Komoriya, K.1
Hoshide, S.2
Takeda, K.3
Kobayashi, H.4
Kubo, J.5
Tsuchimoto, M.6
Nakachi, T.7
Yamanaka, H.8
Kamatani, N.9
-
34
-
-
10344254333
-
PK/PD and safety of a single dose of TMX-67 (febuxostat) in subjects with mild and moderate renal impairment
-
579817
-
579817 PK/PD and safety of a single dose of TMX-67 (febuxostat) in subjects with mild and moderate renal impairment. Hoshide S, Takahashi Y, Ishikawa T, Kubo J, Tsuchimoto M, Komoriya K, Ohno I, Hosoya T NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS 2004 23 8-9 1117-1118
-
(2004)
Nucleosides Nucleotides Nucleic Acids
, vol.23
, Issue.8-9
, pp. 1117-1118
-
-
Hoshide, S.1
Takahashi, Y.2
Ishikawa, T.3
Kubo, J.4
Tsuchimoto, M.5
Komoriya, K.6
Ohno, I.7
Hosoya, T.8
-
35
-
-
10344260696
-
Febuxostat (TMX-67), a novel, non-purine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteers
-
579818
-
579818 Febuxostat (TMX-67), a novel, non-purine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteers. Becker MA, Kisicki J, Khosravan R, Wu J, Mulford D, Hunt B, MacDonald P, Joseph-Ridge N NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS 2004 23 8-9 1111-1116
-
(2004)
Nucleosides Nucleotides Nucleic Acids
, vol.23
, Issue.8-9
, pp. 1111-1116
-
-
Becker, M.A.1
Kisicki, J.2
Khosravan, R.3
Wu, J.4
Mulford, D.5
Hunt, B.6
MacDonald, P.7
Joseph-Ridge, N.8
-
36
-
-
28244479512
-
-
590987 American Society of Clinical Pharmacology and Therapeutics - 2005 Annual Meeting, Orlando, FL, USA IDDB MEETING REPORT March 02-06
-
590987 American Society of Clinical Pharmacology and Therapeutics - 2005 Annual Meeting, Orlando, FL, USA. Susman E, Susman R IDDB MEETING REPORT 2005 March 02-06
-
(2005)
-
-
Susman, E.1
Susman, R.2
-
37
-
-
28244447969
-
Teijin: Pharma, home health care sales up 2.1% to ¥73.7 billion
-
592281
-
592281 Teijin: Pharma, home health care sales up 2.1% to ¥73.7 billion. PHARMA JPN 2005 1932 21
-
(2005)
Pharma. Jpn.
, vol.1932
, pp. 21
-
-
-
38
-
-
28244473695
-
Usefulness of new gout remedy TMX-67 reported: JSGNAM meeting
-
592289
-
592289 Usefulness of new gout remedy TMX-67 reported: JSGNAM meeting. PHARMA JPN 2005 1932 26
-
(2005)
Pharma. Jpn.
, vol.1932
, pp. 26
-
-
-
39
-
-
13444257733
-
Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
-
607074
-
607074 Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase. Takano Y, Hase-Aoki K, Horiuchi H, Zhao L, Kasahara Y, Kondo S, Becker MA LIFE SCI 2005 76 16 1835-1847
-
(2005)
Life Sci.
, vol.76
, Issue.16
, pp. 1835-1847
-
-
Takano, Y.1
Hase-Aoki, K.2
Horiuchi, H.3
Zhao, L.4
Kasahara, Y.5
Kondo, S.6
Becker, M.A.7
-
40
-
-
14944345365
-
Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: A twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout
-
607075
-
607075 Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: A twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout. Becker MA, Schumacher HRJ, Wortmann RL, MacDonald PA, Palo WA, Eustace D, Vernillet L, Joseph-Ridge N ARTHRITIS RHEUM 2005 52 3 916-923
-
(2005)
Arthritis Rheum.
, vol.52
, Issue.3
, pp. 916-923
-
-
Becker, M.A.1
Schumacher, H.R.J.2
Wortmann, R.L.3
MacDonald, P.A.4
Palo, W.A.5
Eustace, D.6
Vernillet, L.7
Joseph-Ridge, N.8
-
41
-
-
18144366916
-
Recent advances in the management of gout and hyperuricemia
-
607076
-
607076 Recent advances in the management of gout and hyperuricemia. Wortmann RL CURR OPIN RHEUMATOL 2005 17 3 319-324
-
(2005)
Curr. Opin. Rheumatol.
, vol.17
, Issue.3
, pp. 319-324
-
-
Wortmann, R.L.1
-
42
-
-
17144396355
-
Pharmacokinetics and pharmacodynamics of febuxostat, a new non-purine selective inhibitor of xanthine oxidase in subjects with renal impairment
-
607077
-
607077 Pharmacokinetics and pharmacodynamics of febuxostat, a new non-purine selective inhibitor of xanthine oxidase in subjects with renal impairment. Mayer MD, Khosravan Reza VL, Wu JT, Joseph-Ridge N, Mulford DJ AM J THER 2005 12 1 22-34
-
(2005)
Am. J. Ther.
, vol.12
, Issue.1
, pp. 22-34
-
-
Mayer, M.D.1
Khosravan Reza, V.L.2
Wu, J.T.3
Joseph-Ridge, N.4
Mulford, D.J.5
-
43
-
-
28244464923
-
A phase 3 study comparing the safety and efficacy of oral febuxostat and allopurinol in subjects with hyperuricemia and gout
-
607078
-
607078 A phase 3 study comparing the safety and efficacy of oral febuxostat and allopurinol in subjects with hyperuricemia and gout. Becker MA, Schumacher HR, Wortmann RL, MacDonald PA, Palo W, Eustace D, Joseph RN ARTHRITIS RHEUM 2004 50 12 4103-4104
-
(2004)
Arthritis Rheum.
, vol.50
, Issue.12
, pp. 4103-4104
-
-
Becker, M.A.1
Schumacher, H.R.2
Wortmann, R.L.3
MacDonald, P.A.4
Palo, W.5
Eustace, D.6
Joseph, R.N.7
-
44
-
-
6344278025
-
Y-700 (1-(3-cyano-4-(2,2-dimethylpropoxy)phenyl)-1H-pyrazole-4-carboxylic acid): A potent xanthine oxidoreductase inhibitor with hepatic excretion
-
607081
-
607081 Y-700 (1-(3-cyano-4-(2,2-dimethylpropoxy)phenyl)-1H-pyrazole-4-carboxylic acid): A potent xanthine oxidoreductase inhibitor with hepatic excretion. Fukunari A, Okamoto K, Nishino T, Eger BT, Pai EF, Kamezawa M, Yamada I, Kato N J PHARMACOL EXP THER 2004 311 2 519-528
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.311
, Issue.2
, pp. 519-528
-
-
Fukunari, A.1
Okamoto, K.2
Nishino, T.3
Eger, B.T.4
Pai, E.F.5
Kamezawa, M.6
Yamada, I.7
Kato, N.8
-
45
-
-
28244482879
-
Ipsen: Dynamic growth confirmed in 2004
-
607224 Ipsen PRESS RELEASE May 11
-
607224 Ipsen: Dynamic growth confirmed in 2004. Ipsen PRESS RELEASE 2005 May 11
-
(2005)
-
-
-
46
-
-
28244458165
-
Ipsen website pipeline
-
612675 Ipsen COMPANY WORLD WIDE WEB SITE July 18
-
612675 Ipsen website pipeline. Ipsen COMPANY WORLD WIDE WEB SITE 2005 July 18
-
(2005)
-
-
-
47
-
-
0038391240
-
A literature review of the epidemiology and treatment of acute gout
-
621011
-
621011 A literature review of the epidemiology and treatment of acute gout. Kim KY, Ralph Schumacher H, Hunsche E, Wertheimer AI, Kong SX CLIN THER 2003 25 6 1593-1617
-
(2003)
Clin. Ther.
, vol.25
, Issue.6
, pp. 1593-1617
-
-
Kim, K.Y.1
Ralph Schumacher, H.2
Hunsche, E.3
Wertheimer, A.I.4
Kong, S.X.5
-
48
-
-
8344222080
-
Management of acute and chronic gouty arthritis: Present state-of-the-art
-
621073
-
621073 Management of acute and chronic gouty arthritis: Present state-of-the-art. Schlesinger N DRUGS 2004 64 2399-2416
-
(2004)
Drugs
, vol.64
, pp. 2399-2416
-
-
Schlesinger, N.1
-
50
-
-
0034630917
-
Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992
-
621079
-
621079 Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. Fang J, Alderman MH J AM MED ASSOC 2000 283 18 2404-2410
-
(2000)
J. Am. Med. Assoc.
, vol.283
, Issue.18
, pp. 2404-2410
-
-
Fang, J.1
Alderman, M.H.2
-
51
-
-
0036231531
-
Gout and hyperuricemia
-
621081
-
621081 Gout and hyperuricemia. Wortmann RL CURR OPIN RHEUMATOL 2002 14 3 281-286
-
(2002)
Curr. Opin. Rheumatol.
, vol.14
, Issue.3
, pp. 281-286
-
-
Wortmann, R.L.1
-
52
-
-
18144408483
-
Gout flare prophylaxis during management of chronic gout with febuxostat, a non-purine selective inhibitor of xanthine oxidase
-
622265 801/103
-
622265 Gout flare prophylaxis during management of chronic gout with febuxostat, a non-purine selective inhibitor of xanthine oxidase. Wortmann R, Becker MA, Schumacher HR, MacDonald P, Palo WA, Joseph-Ridge N ARTHRITIS RHEUM 2004 50 Suppl 9 801/103
-
(2004)
Arthritis Rheum.
, vol.50
, Issue.SUPPL. 9
-
-
Wortmann, R.1
Becker, M.A.2
Schumacher, H.R.3
MacDonald, P.4
Palo, W.A.5
Joseph-Ridge, N.6
-
53
-
-
28244443708
-
Magnetic resonance imaging of gouty tophi during treatment with febuxostat, a non-purine selective inhibitor of xanthine oxidase
-
622288 802/103
-
622288 Magnetic resonance imaging of gouty tophi during treatment with febuxostat, a non-purine selective inhibitor of xanthine oxidase. Becker MA, Schumacher R, Wortmann R, MacDonald P, Palo W, Joseph-Ridge N ARTHRITIS RHEUM 2004 50 Suppl 9 802/103
-
(2004)
Arthritis Rheum.
, vol.50
, Issue.SUPPL. 9
-
-
Becker, M.A.1
Schumacher, R.2
Wortmann, R.3
MacDonald, P.4
Palo, W.5
Joseph-Ridge, N.6
-
54
-
-
22744448920
-
Febuxostat, a novel non-purine selective inhibitor of xanthine oxidase, in an allopurinol-controlled phase III clinical trial in Japanese subjects with gout or hyperuricemia
-
622707 804/103
-
622707 Febuxostat, a novel non-purine selective inhibitor of xanthine oxidase, in an allopurinol-controlled phase III clinical trial in Japanese subjects with gout or hyperuricemia. Kamatani N, Fujimori S, Hada T, Hosoya T, Matsuzawa Y, Ueda T, Yamanaka H, Kato R ARTHRITIS RHEUM 2004 50 Suppl 9 804/103
-
(2004)
Arthritis Rheum.
, vol.50
, Issue.SUPPL. 9
-
-
Kamatani, N.1
Fujimori, S.2
Hada, T.3
Hosoya, T.4
Matsuzawa, Y.5
Ueda, T.6
Yamanaka, H.7
Kato, R.8
-
55
-
-
9244251103
-
Prevention and treatment of the metabolic syndrome
-
623063
-
623063 Prevention and treatment of the metabolic syndrome. Daskalopoulou SS, Mikhailidis DP, Elisaf M ANGIOLOGY 2004 55 6 589-612
-
(2004)
Angiology
, vol.55
, Issue.6
, pp. 589-612
-
-
Daskalopoulou, S.S.1
Mikhailidis, D.P.2
Elisaf, M.3
-
56
-
-
0030584230
-
The management of gout
-
623111
-
623111 The management of gout. Emmerson BT N ENGL J MED 1996 334 7 445-451
-
(1996)
N. Engl. J. Med.
, vol.334
, Issue.7
, pp. 445-451
-
-
Emmerson, B.T.1
-
57
-
-
0035093686
-
Treatment of chronic gout. Can we determine when urate stores are depleted enough to prevent attacks of gout?
-
623112
-
623112 Treatment of chronic gout. Can we determine when urate stores are depleted enough to prevent attacks of gout? Li-Yu J, Clayburne G, Sieck M, Beutler A, Rull M, Eisner E, Schumacher HR Jr J RHEUMATOL 2001 28 3 577-580
-
(2001)
J. Rheumatol.
, vol.28
, Issue.3
, pp. 577-580
-
-
Li-Yu, J.1
Clayburne, G.2
Sieck, M.3
Beutler, A.4
Rull, M.5
Eisner, E.6
Schumacher Jr., H.R.7
-
58
-
-
0023711661
-
Clinical aspects of monosodium urate monohydrate crystal deposition disease (gout)
-
623119
-
623119 Clinical aspects of monosodium urate monohydrate crystal deposition disease (gout). Becker MA RHEUM DIS CLIN NORTH AM 1988 14 2 377-394
-
(1988)
Rheum. Dis. Clin. North Am.
, vol.14
, Issue.2
, pp. 377-394
-
-
Becker, M.A.1
-
59
-
-
22744439304
-
Effects of age and gender on febuxostat pharmacokinetics. Pharmacodynamics, and safety in healthy subjects
-
623353
-
623353 Effects of age and gender on febuxostat pharmacokinetics. Pharmacodynamics, and safety in healthy subjects. Khosravan R, Kukulka M, Wu JT, Joseph-Ridge N Vernillet L CLIN PHARMACOL THER 2005 77 2 Suppl S P50
-
(2005)
Clin. Pharmacol. Ther.
, vol.77
, Issue.2 SUPPL. S
-
-
Khosravan, R.1
Kukulka, M.2
Wu, J.T.3
Joseph-Ridge, N.4
Vernillet, L.5
-
60
-
-
22744431650
-
Effect of febuxostat on pharmacokinetics of desipramine, a CYP2D6 substrate, in healthy subjects
-
623354 S
-
623354 Effect of febuxostat on pharmacokinetics of desipramine, a CYP2D6 substrate, in healthy subjects. Khosravan R, Erdman K, Vernillet L, Wu J T, Joseph-Ridge N, Umeda S, Mulford D CLIN PHARMACOL THER 2005 77 2 Suppl S P43
-
(2005)
Clin. Pharmacol. Ther.
, vol.77
, Issue.2 SUPPL.
-
-
Khosravan, R.1
Erdman, K.2
Vernillet, L.3
Wu, J.T.4
Joseph-Ridge, N.5
Umeda, S.6
Mulford, D.7
-
61
-
-
22744439304
-
Effect of food or antacid in febuxostat pharmacokinetics and pharmacodynamics in healthy subjects
-
623355
-
623355 Effect of food or antacid in febuxostat pharmacokinetics and pharmacodynamics in healthy subjects. Khosravan R, Grabowski V, Wu JT, Joseph Ridge N, Vernillet L CLIN PHARMACOL THER 2005 77 2 P50
-
(2005)
Clin. Pharmacol. Ther.
, vol.77
, Issue.2
-
-
Khosravan, R.1
Grabowski, V.2
Wu, J.T.3
Joseph Ridge, N.4
Vernillet, L.5
-
62
-
-
8344222125
-
A safety and efficacy clinical trial of a novel non-purine selective inhibitor of xanthine oxidase, febuxostat in subjects with gout
-
623356
-
623356 A safety and efficacy clinical trial of a novel non-purine selective inhibitor of xanthine oxidase, febuxostat in subjects with gout. Becker MA, Schumacher H Jr, Wortmann RL, Joseph Ridge N, Lademacher C ANN RHEUM DIS 2004 63 Suppl 1 OP0007
-
(2004)
Ann. Rheum. Dis.
, vol.63
, Issue.SUPPL. 1
-
-
Becker, M.A.1
Schumacher Jr., H.2
Wortmann, R.L.3
Joseph Ridge, N.4
Lademacher, C.5
-
63
-
-
27744498728
-
Recent advances in the epidemiology of gout
-
623381
-
623381 Recent advances in the epidemiology of gout. Saag KG, Mikuls TR CURR RHEUMATOL REP 2005 7 235-241
-
(2005)
Curr. Rheumatol. Rep.
, vol.7
, pp. 235-241
-
-
Saag, K.G.1
Mikuls, T.R.2
-
64
-
-
15244349566
-
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
-
623481
-
623481 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Hung SI, Chung WH, Liou LB, Chu CC, Lin M, Huang HP, Lin YL, Lan JL, Yang LC, Hong HS, Chen MJ et al PROC NATL ACAD SCI USA 2005 102 11 4134-4139
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, Issue.11
, pp. 4134-4139
-
-
Hung, S.I.1
Chung, W.H.2
Liou, L.B.3
Chu, C.C.4
Lin, M.5
Huang, H.P.6
Lin, Y.L.7
Lan, J.L.8
Yang, L.C.9
Hong, H.S.10
Chen, M.J.11
-
65
-
-
28244432905
-
Abt: Stock down but lots of positive catalysts on TAP
-
626466 BEAR STREANS GROUP MORNING MEET NOTES September 20
-
626466 Abt: Stock down but lots of positive catalysts on TAP. Wise R, Bailey M BEAR STEARNS GROUP MORNING MEET NOTES 2004 September 20 1-3
-
(2004)
, pp. 1-3
-
-
Wise, R.1
Bailey, M.2
|