Glutathione depletion modulates gene expression in HepG2 cells via activation of protein kinase C alpha

Toxicology

Volumn 216, Issue 2-3, 2005, Pages 168-180

  White, Angela T ^a,b   Spence, Fiona J ^c   Chipman, James K ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Cell signalling; Glutathione; Oxidative stress; Protein kinase C; Toxicogenomics

Indexed keywords

GAMMA GLUTAMYLCYSTEINE; GLUTATHIONE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C GAMMA; THIOL;

APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; DNA MICROARRAY; ENZYME ACTIVATION; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; OXIDATION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BUTHIONINE SULFOXIMINE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; HUMANS; L-LACTATE DEHYDROGENASE; LIVER NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 28244436401     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.08.001     Document Type: Article

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