Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding

Free Radical Biology and Medicine

Volumn 29, Issue 12, 2000, Pages 1280-1290

  Domenicotti, Cinzia ^a   Paola, Dimitri ^a   Vitali, Antonella ^a   Nitti, Mariapaola ^a   D'Abramo, Cristina ^a   Cottalasso, Damiano ^a   Maloberti, Giuseppe ^a   Biasi, Fiorella ^b   Poli, Giuseppe ^c   Chiarpotto, Elena ^c   Marinari, Umberto M ^a   Pronzato, Maria A ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

Apoptosis; Free radicals; Glutathione; Nuclear transcription factors; Oxidative stress; Protein kinase C isoforms

Indexed keywords

BUTHIONINE SULFOXIMINE; DNA FRAGMENT; GLUTATHIONE; ISOENZYME; MALEIC ACID DIETHYL ESTER; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; ROTTLERIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; DISEASE SEVERITY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; GLUTATHIONE METABOLISM; LIVER CELL; LIVER INJURY; MALE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DNA BINDING; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BUTHIONINE SULFOXIMINE; CELL NUCLEUS; CELLS, CULTURED; GLUTATHIONE; HEPATOCYTES; HUMANS; ISOENZYMES; KINETICS; LIVER; MALE; MALEATES; PROTEIN KINASE C; RATS; RATS, WISTAR; TRANSCRIPTION FACTOR AP-1;

EID: 0034672604     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00429-9     Document Type: Article

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