Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24

American Journal of Human Genetics

Volumn 77, Issue 6, 2005, Pages 1102-1111

  Schumacher, Johannes ^a   Kaneva, Radka ^b   Jamra, Rami Abou ^a   Diaz, Guillermo Orozco ^c   Ohlraun, Stephanie ^d   Milanova, Vihra ^b   Lee, Young Ae ^e   Rivas, Fabio ^c   Mayoral, Fermin ^c   Fuerst, Robert ^a   Plaquer, Antonia ^a   Windemuth, Christine ^a   Gay, Eudoxia ^f   Sanz, Sebastian ^f   González, Maria José ^g   Gil, Susana ^h   Cabaleiro, Francisco ⁱ   Del Rio, Francisco ^j   Perez, Fermin ^k   Haro, Jesus ^l   Kostov, Christian ^b   Chorbov, Vesselin ^b   Nikolova Hill, Amelia ^m,s   Stoyanova, Vessela ^b   Onchev, George ^b   Kremensky, Ivo ^b   Strauch, Konstantin ⁿ   Schulze, Thomas G ^d   Nürnberg, Peter ^e   Gaebel, Wolfgang ^o   Klimke, Ansgar ^o   Auburger, Georg ^p   Wienker, Thomas F ^a   Kalaydjieva, Luba ^q   Propping, Peter ^a   Cichon, Sven ^a   Jablensky, Assen ^r   Rietschel, Marcella ^d   Nöthen, Markus M ^a   more..

^a UNIVERSITY OF BONN   (Germany)

^b MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^c HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^d CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^f HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^g Mental Health Care Centre Lucena   (Spain)

^h Mental Health Care Centre Montoro   (Spain)

ⁱ Province Hospital   (Spain)

^j Mental Health Care Cenfe de San Dionisio Jerez de la Frontera Cádiz   (Spain)

^k URA   (Spain)

^l Mental Health Care Centre Algeciras Cádiz   (Spain)

^m Newcastle Regional Mental Health Services   (Australia)

ⁿ PHILIPPS UNIVERSITY MARBURG   (Germany)

^o HEINRICH HEINE UNIVERSITY   (Germany)

^p GOETHE UNIVERSITY   (Germany)

^q UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^r UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^s Hunter New England Children's Health Network   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOINFORMATICS; BIPOLAR DISORDER; BULGARIA; CHROMOSOME 1P; CHROMOSOME 4Q; CHROMOSOME 6Q; FAMILY STUDY; GENE LOCUS; GENETIC LINKAGE; GENETIC MODEL; GENETIC SUSCEPTIBILITY; GERMANY; HUMAN; NONPARAMETRIC TEST; PRIORITY JOURNAL; SPAIN;

EID: 28144436565     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/498619     Document Type: Article

References (36)

1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR (2002) Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30:97-1001
2. American Psychiatric Association (1994) DSM-IV: diagnostic and statistical manual of mental disorders, 4th ed. American Psychiatric Association, Washington, DC
3. Badner JA, Gershon ES (2002) Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7:405-411
4. Björnsson Á, Gudmundsson G, Gudfinnsson E, Hrafnsdóttir M, Benedikz J, Skúladóttir S, Kristjánsson K, Frigge ML, Kong A, Stefánsson K, Gulcher JR (2003) Localization of a gene for migraine without aura to chromosome 4q21. Am J Hum Genet 73:986-993 (erratum 76:715)
5. Cichon S, Schumacher J, Müller DJ, Hinter M, Windemuth C, Strauch K, Hemmer S, et al (2001) A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q. Hum Mol Genet 25:2933-2944
6. Clerget-Darpoux F, Bonaiti-Pellie C, Hochez J (1986) Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42:393-399
7. Craddock N, Jones I (1999) Genetics of bipolar disorder. J Med Genet 36:585-594
8. Curtis D, Kalsi G, Brynjolfsson J, Mclnnis M, O'Neill J, Smyth C, Moloney E, Murphy P, McQuillin A, Petursson H, Gurling H (2003) Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q. Psychiatr Genet 13:77-84
9. Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe PR, et al (2003) Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet 73:107-114
10. Ekholm JM, Kieseppa T, Hiekkalinna T, Partonen T, Paunio T, Perola M, Ekelund J, Lonnqvist J, Pekkarinen-Ijas P, Peltonen L (2003) Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder. Hum Mol Genet 12:1907-1915
11. Endicott J, Spitzer RL (1978) A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35:837-844
12. Ewald H, Flint T, Kruse TA, Mors O (2002) A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. Mol Psychiatry 7:734-744
13. Fallin MD, Lasseter VK, Wolyniec PS, McGrath JA, Nestadt G, Valle D, Liang K-Y, Pulver AE (2004) Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish families. Am J Hum Genet 75:204-219
14. Fangerau H, Ohlraun S, Granath RO, Nöthen MM, Rietschel M, Schulze TG (2004) Computer-assisted phenotype characterization for genetic research in psychiatry. Hum Heredity 58:122-130
15. Hodge SE, Abreu PC, Greenberg DA (1997) Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study. Am J Hum Genet 60:217-227
16. Kruglyak L, Daly MF, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363
17. Kruglyak L, Lander ES (1998) Faster multipoint linkage analysis using Fourier transforms. J Comput Biol 5:1-7
18. Lee Y-A, Rüschendorf F, Windemuth C, Schmitt-Egenolf M, Stadelmann A, Nüurnberg G, Ständer M, Wienker TF, Reis A, Traupe H (2000) Genomewide scan in German families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13. Am J Hum Genet 67:1020-1024
19. Liu J, Juo SH, Dewan A, Grunn A, Tong X, Brito M, Park N, Loth JE, Kanyas K, Lerer B, Endicott J, Penchaszadeh G, Knowles JA, Ott J, Gilliam TC, Baron M (2003) Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12. Mol Psychiatry 8:333-342
20. Markianos K, Daly MJ, Kruglyak L (2001) Efficient multipoint linkage analysis through reduction of inheritance space. Am J Hum Genet 68:963-977
21. McInnis MG, Dick DM, Willour VL, Avramopoulos D, Mac-Kinnon DF, Simpson SG, Potash JB, et al (2003) Genomewide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health Genetics Initiative bipolar pedigrees. Biol Psychiatry 54:1265-1273
22. Middleton FA, Pato MT, Gentile KL, Morley CP, Zhao X, Eisener AF, Brown A, Petryshen TL, Kirby AN, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Soares MJ, Ferreira CP, Lei M, Azevedo MH, Kennedy JL, Daly MJ, Sklar P, Pato CN (2004) Genomewide linkage analysis of bipolar disorder by use of a high-density single-nucleotide-polymorphism (SNP) gsnotyping assay: a comparison with microsatellite marker assays and finding of significant linkage to chromosome 6q22. Am J Hum Genet 74:886-897
23. Pato CN, Pato MT, Kirby A, Petryshen TL, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Soares MJ, Ferreira CP, Lei M, Verner A, Hudson TJ, Morley CP, Kennedy JL, Azevedo MH, Daly MJ, Sklar P (2004) Genome-wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: fine mapping adds support on chromosomes 6 and 11. Am J Med Genet B Neuropsychiatr Genet 127:30-34
24. Rice JP, Goate A, Williams JT, Bierut L, Dorr D, Wu W, Shears S, Gopalakrishrian G, Edenberg HJ, Foroud T, Nurnberger J Jr, Gershon ES, Detera-Wadleigh SD, Goldin LR, Guroff JJ, McMahon FJ, Simpson S, MacKinnon D, McInnis M, Stine OC, DePaulo JR, Blehar MC, Reich T (1997) Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 1, 6, 8, 10, and 12. Am J Med Genet 74:247-253
25. Schulze TG, McMahon FJ (2003) Genetic linkage and association studies in bipolar affective disorder: a time for optimism. Am J Med Genet C Semin Med Genet 123:36-47
26. Schulze TG, Buervenich S, Badner JA, Steele CJ, Detera-Wadleigh SD, Dick D, Foroud T, Cox NJ, MacKinnon DF, Potash JB, Berrettini WH, Byerley W, Coryell W, DePaulo JR Jr, Gershon ES, Kelsoe JR, McInnis MG, Murphy DL, Reich T, Scheftner W, Nurnberger JI Jr, McMahon FJ (2004) Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the National Institute of Mental Health Genetics Initiative pedigrees. Biol Psychiatry 56:18-23
27. Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, Craddock N, et al (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: bipolar disorder. Am J Hum Genet 73:49-62
28. Strauch K (2003) Parametric linkage analysis with automatic optimization of the disease model parameters. Am J Hum Genet Suppl 73:A2624
29. Strauch K, Fimmers R, Kurz T, Deichmann KA, Wienker TF, Baur MP (2000) Parametric and nonparametric multipoint linkage analysis with imprinting and two-locus-trait models: application to mite sensitization. Am J Hum Genet 66:1945-1957
30. Suarez BK, Hampe CL, van Eerdewegh P (1994) Problems of replicating linkage claims in psychiatry. In: Gershon ES, Cloninger CR, Genetic (eds) Approaches to mental disorders. American Psychiatric Press, Washington, DC, and London, pp 23-46
31. Terwilliger JD, Shannon WD, Lathrop GM, Nolan JP, Goldin LR, Chase GA, Weeks DE (1997) True and false positive peaks in genomewide scans: applications of length-biased sampling to linkage mapping. Am J Hum Genet 61:430-438
32. Venken T, Claes S, Sluijs S, Paterson AD, van Duijn C, Adolfsson R, Del-Favero J, Van Broeckhoven C (2005) Genomewide scan for affective disorder susceptibility loci in families of a northern Swedish isolated population. Am J Hum Genet 76:237-248
33. Weeks DE, Lehner T, Squires-Wheeler E, Kaufmann C, Ott J (1990) Measuring the inflation of the lod score due to its maximization over model parameter values in human linkage analysis. Genet Epidemiol 7:237-243
34. Wing JK, Babor T, Brugha T, Burke J, Cooper JE, Giel T, Jablenski A, Regier D, Sartorius N (1990) SCAN: schedules for clinical assessment in neuropsychiatry. Arch Gen Psychiatry 47:589-592
35. World Health Organization (2002) World Health Report 2002 (http://www.who.int/whr/2002/whr2002_annex3.pdf) (accessed October 19, 2005)
36. Zubenko GS, Maher B, Hughes HB 3rd, Zubenko WN, Stiffler JS, Kaplan BB, Marazita ML (2003) Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression. Am J Med Genet B Neuropsychiatr Genet 123:1-18