Genomewide scan for affective disorder susceptibility loci in families of a northern Swedish isolated population

American Journal of Human Genetics

Volumn 76, Issue 2, 2005, Pages 237-248

  Venken, Tine ^a   Claes, Stephan ^a,b   Sluijs, Samuël ^a   Paterson, Andrew D ^c   Van Duijn, Cornelia ^a,d   Adolfsson, Rolf ^e   Del Favero, Jurgen ^a   Van Broeckhoven, Christine ^a,f  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e UMEÅ UNIVERSITY   (Sweden)

^f UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BIPOLAR DEPRESSION; BIPOLAR MANIA; CHROMOSOME 2Q; CHROMOSOME 6Q; CHROMOSOME 9Q; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE MAPPING; GENEALOGY; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS; SWEDEN; TANDEM REPEAT;

EID: 12344308063     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/427836     Document Type: Article

References (42)

1. Badenhop RF, Moses MJ, Scimone A, Mitchell PB, Ewen-White KR, Rosso A, Donald JA, Adams LJ, Schofield PR (2002) A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes 9, 13 and 19. Mol Psychiatry 7: 594-603
2. Badner JA, Gershon ES (2002) Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7:405-411
3. Bailer U, Leisch F, Meszaros K, Lenzinger E, Willinger U, Strobl R, Heiden A, Gebhardt C, Doge E, Fuchs K, Sieghart W, Kasper S, Hornik K, Aschauer HN (2002) Genome scan for susceptibility loci for schizophrenia and bipolar disorder. Biol Psychiatry 52:40-52
4. Balciuniene J, Yuan QP, Engstrom C, Lindblad K, Nylander PO, Sundvall M, Schalling M, Pettersson U, Adolfsson R, Jazin EE (1998) Linkage analysis of candidate loci in families with recurrent major depression. Mol Psychiatry 3:162-168
5. Baron (2002) Manic-depression genes and the new millennium: poised for discovery. Mol Psychiatry 7:342-358
6. Bennett P, Segurado R, Jones I, Bort S, McCandless F, Lambert D, Heron J, Comerford C, Middle F, Corvin A, Pelios G, Kirov G, Larsen B, Mulcahy T, Williams N, O'Connell R, O'Mahony E, Payne A, Owen M, Holmans P, Craddock N, Gill M (2002) The Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report. Mol Psychiatry 7:189-200
7. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, et al (2002) Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci USA 99:13675-13680
8. Cichon S, Schumacher J, Muller DJ, Hurter M, Windemuth C, Strauch K, Hemmer S, et al (2001) A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q. Hum Mol Genet 10:2933-2944
9. Craddock N, Jones I (1999) Genetics of bipolar disorder. J Med Genet 36:585-594
10. Detera-Wadleigh SD, Badner JA, Yoshikawa T, Sanders AR, Goldin LR, Turner G, Rollins DY, Moses T, Guroff JJ, Kazuba D, Maxwell ME, Edenberg HJ, Foroud T, Lahiri D, Nurnberger JI Jr, Stine OC, McMahon F, Meyers DA, MacKinnon D, Simpson S, McInnis M, DePaulo JR, Rice J, Goate A, Gershon ES (1997) Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 4, 7, 9, 18, 19, 20, and 21q. Am J Med Genet 74:254-262
11. Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe PR, et al (2003) Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet 73:107-114
12. Ellegren H (2004) Microsatellites: simple sequences with complex evolution. Nat Rev Genet 5:435-445
13. Ewald H, Flint T, Kruse TA, Mors O (2002) A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. Mol Psychiatry 7:734-744
14. Ewald H, Kruse TA, Mors O (2003) Genome wide scan using homozygosity mapping and linkage analyses of a single pedigree with affective disorder suggests oligogenic inheritance. Am J Med Genet 120B:63-71
15. Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, Shlien A, Palsson ST, Frigge ML, Thorgeirsson TE, Gulcher JR, Stefansson K (2002) A high-resolution recombination map of the human genome. Nat Genet 31:241-247
16. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363
17. Kruglyak L, Lander ES (1998). Faster multipoint linkage analysis using Fourier transforms. J Comput Biol 5:1-7
18. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
19. Lathrop GM, Lalouel GM (1984) Easy calculations of lod scores and genetic risks on small computers. Am J Hum Genet 36: 460-465
20. Lerer B, Segman RH, Hamdan A, Kanyas K, Karni O, Kohn Y, Korner M, Lanktree M, Kaadan M, Turetsky N, Yakir A, Kerem B, Macciardi F (2003) Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24. Mol Psychiatry 8:488-498
21. Lindholm E, Aberg K, Ekholm B, Pettersson U, Adolfsson R, Jazin EE (2004) Reconstruction of ancestral haplotypes in a 12-generation schizophrenia pedigree. Psychiatr Genet 14:1-8
22. Lindholm E, Ekholm B, Shaw S, Jalonen P, Johansson G, Pettersson U, Sherrington R, Adolfsson R, Jazin E (2001) A schizophrenia-susceptibility locus at 6q25, in one of the world's largest reported pedigrees. Am J Hum Genet 69:96-105
23. Liu J, Juo SH, Dewan A, Grunn A, Tong X, Brito M, Park N, Loth JE, Kanyas K, Lerer B, Endicott J, Penchaszadeh G, Knowles JA, Ott J, Gilliam TC, Baron M (2003) Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12. Mol Psychiatry 8:333-342
24. Majewski J, Ott J (2000) GT repeats are associated with recombination on human chromosome 22. Genome Res 10:1108-1114
25. Middleton FA, Pato MT, Gentile KL, Morley CP, Zhao X, Eisener AF, Brown A, Petryshen TL, Kirby AN, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Soares MJ, Ferreira CP, Lei M, Azevedo MH, Kennedy JL, Daly MJ, Sklar P, Pato CN (2004) Genomewide linkage analysis of bipolar disorder by use of a high-density single-nucleotide-polymorphism (SNP) genotyping assay: a comparison with microsatellite marker assays and finding of significant linkage to chromosome 6q22. Am J Hum Genet 74: 886-897
26. Müller-Oerlinghausen B, Berghöfer A, Bauer M (2002) Bipolar disorder. Lancet 359:241-247
27. Nilsson LG, Bäckman L, Erngrund K, Nyberg L, Adolfsson R, Bucht G, Karlsson S, Widing M, Winblad B (1997) The Betula prospective cohort study: memory, health and aging. Aging Neuropsychol Cognition 4:1-32
28. Nylander PO, Beckman L (1991) Population studies in northern Sweden. XVII. Estimates of Finnish and Saamish influence. Hum Hered 41:157-167
29. Ott J (1989) Computer simulation methods in human linkage analysis. Proc Natl Acad Sci USA 86:4175-4178
30. Paunio T, Ekelund J, Varilo T, Parker A, Hovatta I, Turunen JA, Rinard K, Foti A, Terwilliger JD, Juvonen H, Suvisaari J, Arajarvi R, Suokas J, Partonen T, Lonnqvist J, Meyer J, Peltonen L (2001) Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Hum Mol Genet 10: 3037-3048
31. Peltonen L, Palotie A, Lange K (2000) Use of population isolates for mapping complex traits. Nat Rev Genet 1:182-190
32. Raymond M, Rousset F (1995) GENEPOP (version 1.2): a population genetics software for exact tests and ecumenicism. J Hered 86:248-249
33. Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, Craddock N, et al (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder. III. Bipolar disorder. Am J Hum Genet 73:49-62
34. Shink E, Morissette J, Sherrington R, Barden N (2004) A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12. Mol Psychiatry (electronically published October 19, 2004; accessed December 20, 2004)
35. Smoller JW, Finn CT (2003) Family, twin and adoption studies of bipolar disorder. Am J Med Genet 123C:48-58
36. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, et al (2002) Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71:877-892
37. Strand M, Prolla TA, Liskay RM, Petes TD (1993) Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365:274-276
38. Thorgeirsson TE, Oskarsson H, Desnica N, Kostic JP, Stefansson JG, Kolbeinsson H, Lindal E, Gagunashvili N, Frigge ML, Kong A, Stefansson K, Gulcher JR (2003) Anxiety with panic disorder linked to chromosome 9q in Iceland. Am J Hum Genet 72:1221-1230
39. Weeks DE, Ott J, Lathrop GM (1990) SLINK: a general simulation program for linkage analysis. Am J Hum Genet 47: A204
40. Wijsman EM, Rosenthal EA, Hall D, Blundell ML, Sobin C, Heath SC, Williams R, Brownstein MJ, Gogos JA, Karayiorgou M (2003) Genome-wide scan in a large complex pedigree with predominantly male schizophrenics from the island of Kosrae: evidence for linkage to chromosome 2q. Mol Psychiatry 8:695-705
41. Wing JK, Babor T, Brugha T, Burke J, Cooper JE, Giel R, Jablenski A, Regier D, Sartorius N (1990) SCAN: schedules for clinical assessment in neuropsychiatry. Arch Gen Psychiatry 47:589-593
42. Zhao JH, Curtis D, Sham PC (2000) Model-free analysis and permutation tests for allelic associations. Hum Hered 50: 133-139