Localization of a Gene for Migraine without Aura to Chromosome 4q21

American Journal of Human Genetics

Volumn 73, Issue 5, 2003, Pages 986-993

  Björnsson, Ásgeir ^a   Gudmundsson, Grétar ^b   Gudfinnsson, Einar ^a   Hrafnsdóttir, María ^c   Benedikz, John ^b   Skúladóttir, Svanhildur ^a   Kristjánsson, Kristleifur ^a   Frigge, Michael L ^a   Kong, Augustine ^a   Stefánsson, Kári ^a   Gulcher, Jeffrey R ^a  

^a DECODE GENETICS   (Iceland)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALLELE; ARTICLE; CHROMOSOME 4Q; CHROMOSOME BAND; CONTROLLED STUDY; FEMALE; GENE FUNCTION; GENE LOCATION; GENE LOCUS; GENE MAPPING; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENOME; GENOTYPE; HUMAN; ICELAND; MAJOR CLINICAL STUDY; MALE; MIGRAINE; PRIORITY JOURNAL; QUESTIONNAIRE;

EID: 0242439277     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/378417     Document Type: Article

References (50)

1. Carlsson A, Forsgren L, Nylander PO, Hellman U, Forsman-Semb K, Holmgren G, Holmberg D, Holmberg M (2002) Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1. Neurology 59:1804-1807
2. De Fusco M, Marconi R, Silvestri L, Atorino L, Rampoldi L, Morgante L, Ballabio A, Aridon P, Casari G (2003) Haplo-insufficiency of ATP1A2 encoding the Na+/K+ pump α2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 33:192-196
3. Ducros A, Denier C, Joutel A, Cecillon M, Lescoat C, Vahedi K, Darcel F, Vicaut E, Bousser MG, Tournier-Lasserve E (2001) The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. N Engl J Med 345:17-24
4. Ducros A, Joutel A, Vahedi K, Cecillon M, Ferreira A, Bernard E, Verier A, Echenne B, Lopez de Munain A, Bousser MG, Tournier-Lasserve E (1997) Mapping of a second locus for familial hemiplegic migraine to 1q21-q23 and evidence of further heterogeneity. Ann Neurol 42:885-890
5. Fjalldal JG, Benediktsson K, Sigurdsson J, Ellingssen LM (2001) Automated genotyping: combining neural networks and decision trees to perform robust allele calling. Proc Int Joint Conf Neural Networks A1-A6
6. Gardner K, Barmada MM, Ptacek LJ, Hoffman EP (1997) A new locus for hemiplegic migraine maps to chromosome 1q31. Neurology 49:1231-1238
7. Gervil M, Ulrich V, Kaprio J, Olesen J, Russell MB (1999a) The relative role of genetic and environmental factors in migraine without aura. Neurology 53:995-999
8. Gervil M, Ulrich V, Kyvik KO, Olesen J, Russell MB (1999b) Migraine without aura: a population-based twin study. Ann Neurol 46:606-611
9. Gudbjartsson DF, Jónasson K, Frigge ML, Kong A (2000) Allegro, a new computer program for multipoint linkage analysis. Nat Genet 25:12-13
10. Gulcher J, Stefánsson K (1998) Population genomics: laying the groundwork for genetic disease modeling and targeting. Clin Chem Lab Med 36:523-527
11. Gulcher JR, Kristjánsson K, Gudbjartsson H, Stefánsson K (2000) Protection of privacy by third-party encryption in genetic research in Iceland. Eur J Hum Genet 8:739-742
12. Headache Classification Committee of the International Headache Society (1988) Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia Suppl 7:1-96
13. Hodge SE (1984) The information contained in multiple sibling pairs. Genet Epidemiol 1:109-122
14. Honkasalo ML, Kaprio J, Winter T, Heikkila K, Sillanpaa M, Koskenvuo M (1995) Migraine and concomitant symptoms among 8167 adult twin pairs. Headache 35:70-78
15. Jones KW, Ehm MG, Pericak-Vance MA, Haines JL, Boyd PR, Peroutka SJ (2001) Migraine with aura susceptibility locus on chromosome 19p13 is distinct from the familial hemiplegic migraine locus. Genomics 78:150-154
16. Joutel A, Bousser MG, Biousse V, Labauge P, Chabriat H, Nibbio A, Maciazek J, Meyer B, Bach MA, Weissenbach J, Lathorp GM, Tournier-Lasserve E (1993) A gene for familial hemiplegic migraine maps to chromosome 19. Nat Genet 5:40-45
17. Kallela M, Wessman M, Farkkila M (2001a) Validation of a migraine-specific questionnaire for use in family studies. Eur J Neurol 8:61-66
18. Kallela M, Wessman M, Farkkila M, Palotie A, Koskenvuo M, Honkasalo ML, Kaprio J (1999) Clinical characteristics of migraine in a population-based twin sample: similarities and differences between migraine with and without aura. Cephalalgia 19:151-158
19. Kallela M, Wessman M, Havanka H, Palotie A, Farkkila M (2001b) Familial migraine with and without aura: clinical characteristics and co-occurrence. Eur J Neurol 8:441-449
20. Kong A, Cox NJ (1997) Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61:1179-1188
21. Kong A, Gudbjartsson DF, Sainz J, Jónsdóttir GM, Gudjónsson SA, Richardsson B, Sigurdardóttir S, Barnard J, Hallbeck B, Másson G, Shlien A, Pálsson ST, Frigge ML, Thorgeirsson TE, Gulcher JR, Stefánsson K (2002) A high-resolution recombination map of the human genome. Nat Genet 31:241-247
22. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multi-point approach. Am J Hum Genet 58:1347-1363
23. Larsson B, Bille B, Pedersen NL (1995) Genetic influence in headaches: a Swedish twin study. Headache 35:513-519
24. Launer LJ, Terwindt GM, Ferrari MD (1999) The prevalence and characteristics of migraine in a population-based cohort: the GEM study. Neurology 53:537-542
25. Lea RA, Shepherd AG, Curtain RP, Nyholt DR, Quinlan S, Brimage PJ, Griffiths LR (2002) A typical migraine susceptibility region localizes to chromosome 1q31. Neurogenetics 4:17-22
26. McCarthy LC, Hosford DA, Riley JH, Bird MI, White NJ, Hewett DR, Peroutka SJ, et al (2001) Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine. Genomics 78:135-149
27. Mochi M, Sangiorgi S, Cortelli P, Carelli V, Scapoli C, Crisci M, Monari L, Pierangeli G, Montagna P (1993) Testing models for genetic determination in migraine. Cephalalgia 13: 389-394
28. Nyholt DR, Curtain RP, Griffiths LR (2000) Familial typical migraine: significant linkage and localization of a gene to Xq24-28. Hum Genet 107:18-23
29. Nyholt DR, Dawkins JL, Brimage PJ, Goadsby PJ, Nicholson GA, Griffiths LR (1998a) Evidence for an X-linked genetic component in familial typical migraine. Hum Mol Genet 7: 459-463
30. Nyholt DR, Lea RA, Goadsby PJ, Brimage PJ, Griffiths LR (1998b) Familial typical migraine: linkage to chromosome 19p13 and evidence for genetic heterogeneity. Neurology 50: 1428-1432
31. Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, Lamerdin JE, Mohrenweiser HW, Bulman DE, Ferrari M, Haan J, Lindhout D, van Ommen GJ, Hofker MH, Ferrari MD, Frants RR (1996) Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca(2+) channel gene CACNL1A4. Cell 87:543-552
32. Pálsson B, Pálsson F, Perlin M, Gudbjartsson H, Stefánsson K, Gulcher J (1999) Using quality measures to facilitate allele calling in high-throughput genotyping. Genome Res 9:1002-1012
33. Rasmussen BK, Olesen J (1992) Migraine with aura and migraine without aura: an epidemiological study. Cephalalgia 12:221-228
34. Russell MB, Iselius L, Olesen J (1995a) Inheritance of migraine investigated by complex segregation analysis. Hum Genet 96: 726-730
35. _ (1996) Migraine without aura and migraine with aura are inherited disorders. Cephalalgia 16:305-309
36. Russell MB, Olesen J (1995) Increased familial risk and evidence of genetic factor in migraine. Brit Med J 311:541-544
37. Russell MB, Rasmussen BK, Thorvaldsen P, Olesen J (1995b) Prevalence and sex-ratio of the subtypes of migraine. Int J Epidemiol 24:612-618
38. Russell MB, Ulrich V, Gervil M, Olesen J (2002) Migraine without aura and migraine with aura are distinct disorders: a population-based twin survey. Headache 42:332-336
39. Soragna D, Vettori A, Carraro G, Marchioni E, Vazza G, Bellini S, Tupler R, Savoldi F, Mostacciuolo ML (2003) A locus for migraine without aura maps on chromosome 14q21.2-q22.3. Am J Hum Genet 72:161-167
40. Stewart WF, Lipton RB, Celentano DD, Reed ML (1992) Prevalence of migraine headache in the United States: relation to age, income, race, and other sociodemographic factors. JAMA 267:64-69
41. Stewart WF, Staffa J, Lipton RB, Ottman R (1997) Familial risk of migraine: a population-based study. Ann Neurol 41: 166-172
42. Svensson DA, Ekbom K, Larsson B, Waldenlind E (2002) Life-time prevalence and characteristics of recurrent primary headaches in a population-based sample of Swedish twins. Headache 42:754-765
43. Terwindt GM, Ophoff RA, van Eijk R, Vergouwe MN, Haan J, Frants RR, Sandkuijl LA, Ferrari MD (2001) Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura. Neurology 56:1028-1032
44. Ulrich V, Gervil M (2000) Twin studies of migraine with and without aura. In: Sydor AM (ed) Frontiers in headache research. Vol 8. Genetics of headache disorders. Lippincott Williams & Wilkins, Philadelphia, pp 27-31
45. Ulrich V, Gervil M, Kirsten F, Olesen J, Russell MB (1999a) The prevalence and characteristics of migraine in twins from the general population. Headache 39:173-180
46. Ulrich V, Gervil M, Kyvik KO, Olesen J, Russell MB (1999b) Evidence of a genetic factor in migraine with aura: a population-based Danish twin study. Ann Neurol 45:242-246
47. Weeks DE, Lange K (1988) The affected-pedigree-member method of linkage analysis. Am J Hum Genet 42:315-326
48. Wessman M, Kallela M, Kaunisto MA, Marttila P, Sobel E, Hartiala J, Oswell G, Leal SM, Papp JC, Hämäläinen E, Broas P, Joslyn G, Hovatta I, Hiekkalinna T, Kaprio J, Ott J, Cantor RM, Zwart J-A, Ilmavirta M, Havanka H, Färkkilä M, Peltonen L, Palotie A (2002) A susceptibility locus for migraine with aura, on chromosome 4q24. Am J Hum Genet 70:652-662
49. Whittemore AS, Halpern J (1994) A class of tests for linkage using affected pedigree members. Biometrics 50:118-127
50. Zhuchenko O, Bailey J, Bonnen P, Ashizawa T, Stockton DW, Amos C, Dobyns WB, Subramony SH, Zoghbi HY, Lee CC (1997) Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the α 1A-voltage-dependent calcium channel. Nat Genet 15:62-69