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Volumn 12, Issue 6, 2005, Pages 481-490

Immunotherapeutic approaches to prevent, ameliorate, and cure type 1 diabetes

Author keywords

Clinical trial; Immunotherapy; Prevention; Type 1 diabetes

Indexed keywords

ALPHA 1 ANTITRYPSIN; ANTIHISTAMINIC AGENT; AUTOANTIBODY; AZATHIOPRINE; BCG VACCINE; CASEIN HYDROLYSATE; CORTICOSTEROID; CYCLOSPORIN A; CYTOKINE; GALACTOSYLCERAMIDE; GLUCOCORTICOID; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 65; GLUTEN; INSULIN; INSULINOMA ASSOCIATED 2 AUTOANTIBODY; INTERLEUKIN 2 MONOCLONAL ANTIBODY; METHOTREXATE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD3; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NICOTINAMIDE; OKT 3; OKT 4; PARVOVIRUS VECTOR; PROINSULIN; PROTEINASE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 28044473162     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mjt.0000178782.97413.79     Document Type: Conference Paper
Times cited : (21)

References (57)
  • 1
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet. 2001;358:221-229.
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 2
    • 0031738116 scopus 로고    scopus 로고
    • Combined use of autoantibodies (IA-2ab, Gadab, IAA, ICA) in type 1 diabetes: Combinatorial islet autoantibody workshop
    • Verge CF, Stenger D, Bonifacio E, et al. Combined use of autoantibodies (IA-2ab, Gadab, IAA, ICA) in type 1 diabetes: Combinatorial islet autoantibody workshop. Diabetes. 1998;47:1857-1866.
    • (1998) Diabetes , vol.47 , pp. 1857-1866
    • Verge, C.F.1    Stenger, D.2    Bonifacio, E.3
  • 3
    • 0033001488 scopus 로고    scopus 로고
    • The NOD mouse model of type 1 diabetes: As good as it gets?
    • Atkinson MA, Leiter EH. The NOD mouse model of type 1 diabetes: as good as it gets? Nat Med. 1999;5:601-604.
    • (1999) Nat Med , vol.5 , pp. 601-604
    • Atkinson, M.A.1    Leiter, E.H.2
  • 4
    • 0034628425 scopus 로고    scopus 로고
    • Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy
    • The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
    • Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. N Engl J Med. 2000;342:381-389.
    • (2000) N Engl J Med , vol.342 , pp. 381-389
  • 5
    • 0029995958 scopus 로고    scopus 로고
    • Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
    • Verge CF, Gianani R, Kawasaki E, et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes. 1996;45:926-933.
    • (1996) Diabetes , vol.45 , pp. 926-933
    • Verge, C.F.1    Gianani, R.2    Kawasaki, E.3
  • 6
    • 0037244718 scopus 로고    scopus 로고
    • Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes
    • Krischer JP, Cuthbertson DD, Yu L, et al. Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. J Clin Endocrinol Metab. 2003;88:103-108.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 103-108
    • Krischer, J.P.1    Cuthbertson, D.D.2    Yu, L.3
  • 7
    • 0025906899 scopus 로고
    • Prediction of the course of pre-type I diabetes
    • Chase HP, Garg SK, Butler-Simon N, et al. Prediction of the course of pre-type I diabetes. J Pediatr. 1991;118:838-841.
    • (1991) J Pediatr , vol.118 , pp. 838-841
    • Chase, H.P.1    Garg, S.K.2    Butler-Simon, N.3
  • 8
    • 0016157440 scopus 로고
    • Concordance in twins: Methods and interpretation
    • Smith C. Concordance in twins: methods and interpretation. Am J Hum Genet. 1974;26:454-466.
    • (1974) Am J Hum Genet , vol.26 , pp. 454-466
    • Smith, C.1
  • 9
    • 0037237655 scopus 로고    scopus 로고
    • Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood
    • Trudeau JD, Kelly-Smith C, Verchere CB, et al. Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood. J Clin Invest. 2003;111:217-223.
    • (2003) J Clin Invest , vol.111 , pp. 217-223
    • Trudeau, J.D.1    Kelly-Smith, C.2    Verchere, C.B.3
  • 10
    • 0035010465 scopus 로고    scopus 로고
    • Restoration of self-tolerance is a feasible approach to control ongoing beta-cell specific autoreactivity: Its relevance for treatment in established diabetes and islet transplantation
    • Chatenoud L. Restoration of self-tolerance is a feasible approach to control ongoing beta-cell specific autoreactivity: its relevance for treatment in established diabetes and islet transplantation. Diabetologia. 2001;44:521-536.
    • (2001) Diabetologia , vol.44 , pp. 521-536
    • Chatenoud, L.1
  • 13
    • 0141796312 scopus 로고    scopus 로고
    • TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
    • Belghith M, Bluestone JA, Barriot S, et al. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med. 2003;9:1202-1208.
    • (2003) Nat Med , vol.9 , pp. 1202-1208
    • Belghith, M.1    Bluestone, J.A.2    Barriot, S.3
  • 15
    • 0042638687 scopus 로고    scopus 로고
    • Testing the hypothesis that the insulin 1 gene is essential for diabetogenesis and knockout of insulin 2 gene accelerates diabetes in NOD mice
    • Moriyama H, Paronen J, Liu E, et al. Testing the hypothesis that the insulin 1 gene is essential for diabetogenesis and knockout of insulin 2 gene accelerates diabetes in NOD mice. Diabetes Metab Res Rev. 2002;18(Suppl 4):S26.
    • (2002) Diabetes Metab Res Rev , vol.18 , Issue.4 SUPPL.
    • Moriyama, H.1    Paronen, J.2    Liu, E.3
  • 16
    • 11144356656 scopus 로고    scopus 로고
    • Establishing insulin 1 and insulin 2 knockout congenic strains on NOD genetic background
    • Paronen J, Moriyama H, Abiru N, et al. Establishing insulin 1 and insulin 2 knockout congenic strains on NOD genetic background. Ann N Y Acad Sci. 2003;1005:205-210.
    • (2003) Ann N Y Acad Sci , vol.1005 , pp. 205-210
    • Paronen, J.1    Moriyama, H.2    Abiru, N.3
  • 17
    • 0038326717 scopus 로고    scopus 로고
    • Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes
    • Steptoe RJ, Ritchie JM, Harrison LC. Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes. J Clin Invest. 2003;111:1357-1363.
    • (2003) J Clin Invest , vol.111 , pp. 1357-1363
    • Steptoe, R.J.1    Ritchie, J.M.2    Harrison, L.C.3
  • 18
    • 10744224092 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus-mediated alpha-1 anti-trypsin gene therapy prevents type I diabetes in NOD mice
    • Song S, Goudy K, Campbell-Thompson M, et al. Recombinant adeno-associated virus-mediated alpha-1 anti-trypsin gene therapy prevents type I diabetes in NOD mice. Gene Ther. 2004;11:181-186.
    • (2004) Gene Ther , vol.11 , pp. 181-186
    • Song, S.1    Goudy, K.2    Campbell-Thompson, M.3
  • 19
    • 0242570736 scopus 로고    scopus 로고
    • Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouse
    • Liu E, Moriyama H, Paronen J, et al. Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouse. J Autoimmun. 2003;21:213-219.
    • (2003) J Autoimmun , vol.21 , pp. 213-219
    • Liu, E.1    Moriyama, H.2    Paronen, J.3
  • 20
    • 0027958044 scopus 로고
    • Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
    • Chatenoud L, Thervet E, Primo J, et al. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci U S A. 1994;91:123-127.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 123-127
    • Chatenoud, L.1    Thervet, E.2    Primo, J.3
  • 21
    • 0025061142 scopus 로고
    • Prevention of overt diabetes and insulitis in NOD mice by a single BCG vaccination
    • Harada M, Kishimoto Y, Makino S. Prevention of overt diabetes and insulitis in NOD mice by a single BCG vaccination. Diabetes. 1990;8:85-90.
    • (1990) Diabetes , vol.8 , pp. 85-90
    • Harada, M.1    Kishimoto, Y.2    Makino, S.3
  • 22
    • 0346496097 scopus 로고    scopus 로고
    • CTLA-4 and tolerance: The biochemical point of view
    • Chikuma S, Bluestone JA. CTLA-4 and tolerance: the biochemical point of view. Immunol Res. 2003;28:241-253.
    • (2003) Immunol Res , vol.28 , pp. 241-253
    • Chikuma, S.1    Bluestone, J.A.2
  • 23
    • 0041806713 scopus 로고    scopus 로고
    • A pancreatic {beta}-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes
    • Hutton JC, Eisenbarth GS. A pancreatic {beta}-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes. Proc Natl Acad Sci U S A. 2003;100:8626-8628.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8626-8628
    • Hutton, J.C.1    Eisenbarth, G.S.2
  • 24
    • 9444263686 scopus 로고    scopus 로고
    • Lack of association between early exposure to cow's milk protein and b-cell autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY)
    • Norris JM, Beaty B, Klingensmith G, et al. Lack of association between early exposure to cow's milk protein and b-cell autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY). JAMA. 1996;276:609-614.
    • (1996) JAMA , vol.276 , pp. 609-614
    • Norris, J.M.1    Beaty, B.2    Klingensmith, G.3
  • 25
    • 0030445613 scopus 로고    scopus 로고
    • Cyclosporine delays but does not prevent clinical onset in glucose intolerant pre-type I diabetic children
    • Carel J-C, Boitard C, Eisenbarth G, et al. Cyclosporine delays but does not prevent clinical onset in glucose intolerant pre-type I diabetic children. J Autoimmun. 1996;9:739-745.
    • (1996) J Autoimmun , vol.9 , pp. 739-745
    • Carel, J.-C.1    Boitard, C.2    Eisenbarth, G.3
  • 26
    • 0024240517 scopus 로고
    • Mechanisms of nicotinamide and thymidine protection from alloxan and streptozotocin toxicity
    • LeDoux SP, Hall CR, Forbes PM, et al. Mechanisms of nicotinamide and thymidine protection from alloxan and streptozotocin toxicity. Diabetes. 1988;37:1015-1019.
    • (1988) Diabetes , vol.37 , pp. 1015-1019
    • Ledoux, S.P.1    Hall, C.R.2    Forbes, P.M.3
  • 27
    • 0020679246 scopus 로고
    • Effect of poly(ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis
    • Uchigata Y, Yamamoto H, Nagai H, et al. Effect of poly(ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis. Diabetes. 1983;32:316-318.
    • (1983) Diabetes , vol.32 , pp. 316-318
    • Uchigata, Y.1    Yamamoto, H.2    Nagai, H.3
  • 28
    • 0025104170 scopus 로고
    • Essential contribution of macrophages to islet cell destruction in vivo and in vitro
    • Kolb H, Burkart V, Appels B, et al. Essential contribution of macrophages to islet cell destruction in vivo and in vitro. J Autoimmun. 1990;3(Suppl 1):117-120.
    • (1990) J Autoimmun , vol.3 , Issue.1 SUPPL. , pp. 117-120
    • Kolb, H.1    Burkart, V.2    Appels, B.3
  • 29
    • 85027607875 scopus 로고
    • Effect of nicotinamide in preventing diabetes (IDDM) in children
    • Elliott RB, Chase HP, Pilcher CC, et al. Effect of nicotinamide in preventing diabetes (IDDM) in children. J Autoimmun. 1990;3:61A.
    • (1990) J Autoimmun , vol.3
    • Elliott, R.B.1    Chase, H.P.2    Pilcher, C.C.3
  • 30
    • 0030036695 scopus 로고    scopus 로고
    • Theory and practice of nicotinamide trials in pre-type 1 diabetes
    • Gale EA. Theory and practice of nicotinamide trials in pre-type 1 diabetes. J Pediatr Endocrinol Metab. 1996;9:375-379.
    • (1996) J Pediatr Endocrinol Metab , vol.9 , pp. 375-379
    • Gale, E.A.1
  • 31
    • 2942587153 scopus 로고    scopus 로고
    • Interferon alpha a potential link in the pathogenesis in the viral induced type 1 diabetes and autoimmunity
    • Devendra D, Eisenbarth GS. Interferon alpha a potential link in the pathogenesis in the viral induced type 1 diabetes and autoimmunity. Clin Immunol. 2004;111:225-233.
    • (2004) Clin Immunol , vol.111 , pp. 225-233
    • Devendra, D.1    Eisenbarth, G.S.2
  • 32
    • 0035900481 scopus 로고    scopus 로고
    • Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus
    • Blanco P, Palucka AK, Gill M, et al. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science. 2001;294:1540-1543.
    • (2001) Science , vol.294 , pp. 1540-1543
    • Blanco, P.1    Palucka, A.K.2    Gill, M.3
  • 33
    • 0026685653 scopus 로고
    • Poly I:C induces development of diabetes mellitus in BB rat
    • Sobel DO, Newsome J, Ewel CH, et al. Poly I:C induces development of diabetes mellitus in BB rat. Diabetes. 1992;41:515-520.
    • (1992) Diabetes , vol.41 , pp. 515-520
    • Sobel, D.O.1    Newsome, J.2    Ewel, C.H.3
  • 34
    • 28044461652 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof.
  • 35
    • 0035823645 scopus 로고    scopus 로고
    • Characterization and humanization of a monoclonal antibody that neutralizes human leukocyte interferon: A candidate therapeutic for IDDM and SLE
    • Chuntharapai A, Lai J, Huang X, et al. Characterization and humanization of a monoclonal antibody that neutralizes human leukocyte interferon: a candidate therapeutic for IDDM and SLE. Cytokine. 2001;15:250-260.
    • (2001) Cytokine , vol.15 , pp. 250-260
    • Chuntharapai, A.1    Lai, J.2    Huang, X.3
  • 36
    • 0035701950 scopus 로고    scopus 로고
    • Ingested IFN-alpha preserves residual beta cell function in type 1 diabetes
    • Brod SA, Atkinson M, Lavis VR, et al. Ingested IFN-alpha preserves residual beta cell function in type 1 diabetes. J Interferon Cytokine Res. 2001;21:1021-1030.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 1021-1030
    • Brod, S.A.1    Atkinson, M.2    Lavis, V.R.3
  • 37
    • 0036657189 scopus 로고    scopus 로고
    • The DPT-1 trial: A negative result with lessons for future type 1 diabetes prevention
    • Pozzilli P. The DPT-1 trial: a negative result with lessons for future type 1 diabetes prevention. Diabetes Metab Res Rev. 2002;18:257-259.
    • (2002) Diabetes Metab Res Rev , vol.18 , pp. 257-259
    • Pozzilli, P.1
  • 38
    • 0035079772 scopus 로고    scopus 로고
    • Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort
    • Kupila A, Muona P, Simell T, et al. Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia. 2001;44:290-297.
    • (2001) Diabetologia , vol.44 , pp. 290-297
    • Kupila, A.1    Muona, P.2    Simell, T.3
  • 39
    • 0022619110 scopus 로고
    • Cyclosporin increases the rate and length of remissions in insulin dependent diabetes of recent onset. Results of a multicentre double-blind trial
    • Feutren G, Assan G, Karsenty G, et al. Cyclosporin increases the rate and length of remissions in insulin dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet. 1986;2:119-124.
    • (1986) Lancet , vol.2 , pp. 119-124
    • Feutren, G.1    Assan, G.2    Karsenty, G.3
  • 40
    • 0024202984 scopus 로고
    • Clinical trials of cyclosporin in IDDM
    • Dupre J, Stiller CR, Gent M, et al. Clinical trials of cyclosporin in IDDM. Diabetes Care. 1988;11(suppl 1):37-44.
    • (1988) Diabetes Care , vol.11 , Issue.1 SUPPL. , pp. 37-44
    • Dupre, J.1    Stiller, C.R.2    Gent, M.3
  • 41
    • 0030058792 scopus 로고    scopus 로고
    • Long-term results of early cyclosporin therapy in juvenile IDDM
    • DeFilippo G, Carel JC, Boitard C, et al. Long-term results of early cyclosporin therapy in juvenile IDDM. Diabetes. 1996;45:101-104.
    • (1996) Diabetes , vol.45 , pp. 101-104
    • Defilippo, G.1    Carel, J.C.2    Boitard, C.3
  • 42
    • 0037198420 scopus 로고    scopus 로고
    • Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
    • Herold KC, Hagopian W, Auger JA, et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med. 2002;346:1692-1698.
    • (2002) N Engl J Med , vol.346 , pp. 1692-1698
    • Herold, K.C.1    Hagopian, W.2    Auger, J.A.3
  • 43
    • 0031171726 scopus 로고    scopus 로고
    • BCG vaccination prevents insulin-dependent diabetes mellitus (IDDM) in NOD mice after disease acceleration with cyclophosphamide
    • Qin HY, Singh B. BCG vaccination prevents insulin-dependent diabetes mellitus (IDDM) in NOD mice after disease acceleration with cyclophosphamide. J Autoimmun. 1997;10:271-278.
    • (1997) J Autoimmun , vol.10 , pp. 271-278
    • Qin, H.Y.1    Singh, B.2
  • 44
    • 0032883253 scopus 로고    scopus 로고
    • Effect of BCG vaccination on new-onset insulin-dependent diabetes mellitus: A randomized clinical study
    • Allen HF, Klingensmith GJ, Jensen P, et al. Effect of BCG vaccination on new-onset insulin-dependent diabetes mellitus: a randomized clinical study. Diabetes Care. 1998;22:1703-1707.
    • (1998) Diabetes Care , vol.22 , pp. 1703-1707
    • Allen, H.F.1    Klingensmith, G.J.2    Jensen, P.3
  • 45
    • 0035142467 scopus 로고    scopus 로고
    • A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin
    • Alleva DG, Crowe PD, Jin L, et al. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J Clin Invest. 2001;107:173-180.
    • (2001) J Clin Invest , vol.107 , pp. 173-180
    • Alleva, D.G.1    Crowe, P.D.2    Jin, L.3
  • 46
    • 0034987197 scopus 로고    scopus 로고
    • Peptide and MHC specific breaking of humoral tolerance to native insulin with the B:9-23 peptide in diabetes prone and normal mice
    • Abiru N, Maniatis AK, Yu L, et al. Peptide and MHC specific breaking of humoral tolerance to native insulin with the B:9-23 peptide in diabetes prone and normal mice. Diabetes. 2001;50:1274-1281.
    • (2001) Diabetes , vol.50 , pp. 1274-1281
    • Abiru, N.1    Maniatis, A.K.2    Yu, L.3
  • 47
    • 0036300542 scopus 로고    scopus 로고
    • Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide
    • Alleva DG, Gaur A, Jin L, et al. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes. 2002;51:2126-2134.
    • (2002) Diabetes , vol.51 , pp. 2126-2134
    • Alleva, D.G.1    Gaur, A.2    Jin, L.3
  • 48
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
    • Daniel D, Wegmann DR. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci U S A. 1996;93:956-960.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 956-960
    • Daniel, D.1    Wegmann, D.R.2
  • 49
    • 0036790542 scopus 로고    scopus 로고
    • Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23
    • Liu E, Moriyama H, Abiru N, et al. Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23. J Clin Invest. 2002;110:1021-1027.
    • (2002) J Clin Invest , vol.110 , pp. 1021-1027
    • Liu, E.1    Moriyama, H.2    Abiru, N.3
  • 50
    • 0035944844 scopus 로고    scopus 로고
    • Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
    • Raz I, Elias D, Avron A, et al. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet. 2001;358:1749-1753.
    • (2001) Lancet , vol.358 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3
  • 51
    • 0036384845 scopus 로고    scopus 로고
    • Heat shock protein therapy fails to prevent diabetes in NOD mice
    • Bowman M, Atkinson MA. Heat shock protein therapy fails to prevent diabetes in NOD mice. Diabetologia. 2002;45:1350-1351.
    • (2002) Diabetologia , vol.45 , pp. 1350-1351
    • Bowman, M.1    Atkinson, M.A.2
  • 52
    • 0035337721 scopus 로고    scopus 로고
    • A glutamic acid decarboxylase 65-specific Th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic mice
    • Tisch R, Wang B, Atkinson MA, et al. A glutamic acid decarboxylase 65-specific Th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic mice. J Immunol. 2001;166:6925-6936.
    • (2001) J Immunol , vol.166 , pp. 6925-6936
    • Tisch, R.1    Wang, B.2    Atkinson, M.A.3
  • 53
    • 0033178763 scopus 로고    scopus 로고
    • Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent
    • Tisch R, Wang B, Serreze DV. Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent. J Immunol. 1999;163:1178-1187.
    • (1999) J Immunol , vol.163 , pp. 1178-1187
    • Tisch, R.1    Wang, B.2    Serreze, D.V.3
  • 54
    • 0032573681 scopus 로고    scopus 로고
    • Synergistic effects of mycophenolate mofetil and sirolimus in prevention of acute heart, pancreas, and kidney allograft rejection and in reversal of ongoing heart allograft rejection in the rat
    • Vu MD, Qi S, Xu D, et al. Synergistic effects of mycophenolate mofetil and sirolimus in prevention of acute heart, pancreas, and kidney allograft rejection and in reversal of ongoing heart allograft rejection in the rat. Transplantation. 1998;66:1575-1580.
    • (1998) Transplantation , vol.66 , pp. 1575-1580
    • Vu, M.D.1    Qi, S.2    Xu, D.3
  • 55
    • 0027729166 scopus 로고
    • Mycophenolate mofetil can prevent the development of diabetes in BB rats
    • Hao L, Chan S-M, Lafferty KJ. Mycophenolate mofetil can prevent the development of diabetes in BB rats. Ann N Y Acad Sci. 1993;696:328-332.
    • (1993) Ann N Y Acad Sci , vol.696 , pp. 328-332
    • Hao, L.1    Chan, S.-M.2    Lafferty, K.J.3
  • 56
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000;343:230-238.
    • (2000) N Engl J Med , vol.343 , pp. 230-238
    • Shapiro, A.M.1    Lakey, J.R.2    Ryan, E.A.3
  • 57
    • 10744233137 scopus 로고    scopus 로고
    • Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: The National Institutes of Health experience
    • Hirshberg B, Rother KI, Digon BJ III, et al. Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience. Diabetes Care. 2003;26:3288-3295.
    • (2003) Diabetes Care , vol.26 , pp. 3288-3295
    • Hirshberg, B.1    Rother, K.I.2    Digon III, B.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.