Short report: Prevalence of Plasmodium falciparum mutations associated with antimalarial drug resistance during an epidemic in Kuna Yala, Panama, Central America

American Journal of Tropical Medicine and Hygiene

Volumn 73, Issue 5, 2005, Pages 839-841

  Samudio, Franklyn ^a,b   Santamaría, Ana M ^a,b   Obaldía III, Nicanor ^a,b   Pascale, Juan M ^a,b   Bayard, Vicente ^a,b   Calzada, Jose E ^a,b  

^a ICGES   (Panama)

^b Instituto Conmemorativo Gorgas de Estudios de la Salud   (Panama)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FANSIDAR; FOLIC ACID ANTAGONIST; MEFLOQUINE; MEROZOITE SURFACE PROTEIN 2; PRIMAQUINE; PROTOZOAL DNA; PYRIMETHAMINE; SULFADOXINE; PROTOZOAL PROTEIN;

ARTICLE; CENTRAL AMERICA; DRUG SENSITIVITY; EPIDEMIC; GENETIC VARIABILITY; GENOTYPE; GEOGRAPHIC DISTRIBUTION; HUMAN; MALARIA FALCIPARUM; MUTATION; NONHUMAN; PANAMA; PLASMODIUM FALCIPARUM; PREVALENCE; PUBLIC HEALTH; ANIMAL; DRUG EFFECT; DRUG RESISTANCE; EPIDEMIOLOGY; GENETICS; PARASITOLOGY;

KUNA; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; DISEASE OUTBREAKS; DNA, PROTOZOAN; DRUG RESISTANCE; EPIDEMIOLOGY, MOLECULAR; HUMANS; MALARIA, FALCIPARUM; MUTATION; PANAMA; PLASMODIUM FALCIPARUM; PREVALENCE; PROTOZOAN PROTEINS;

EID: 28044450661     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2005.73.839     Document Type: Article

References (20)

1. Ministerio de Salud, Panamá, República de Panamá, Departamento de Vigilancia de los Factures Protectores y de Riesgo a la Salud y Enfermedad. Situación epidemiologica de la malaria en Panamá. Año 2003.
2. Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourte Y, Dicko A, Su XZ, Nomura T, Fidock DA, Wellems TE, Plowe CV, 2001. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 344: 257-263.
3. Schneider AG, Premji Z, Felger I, Smith T, Abdulla S, Beck HP, Mshinda H, 2002. A point mutation in codon 76 of pfcrt of P. falciparum is positively selected for by chloroquine treatment in Tanzania, Infect Genet Evol 1: 183-189.
4. Foote SJ, Kyle DJ, Martin SK, Oduola AMJ, Forsyth K, Kemp DJ, Cowman AF, 1990. Several alleles of the multi-drug resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature 345: 255-258.
5. Price RN, Cassar C, Brockman A, Duraisingh M, Vugt M, White NJ, Nosten F, Krishna S, 1999. The pfmdr1 gene is associated with a multidrug-resitant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob Agents Chemother 43: 2943-2949.
6. Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF, 2000. Pgh 1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403: 906-909.
7. Bhattacharya PR, Biswas S, Kabilan L, 1997. Alleles of the Plasmodium falciparum pfmdr 1 gene appear not to be associated with chloroquine resistance in India. Trans R Soc Trop Med Hyg 91: 454-455.
8. Basco LK, Ringwald P, 1998. Molecular epidemiology of malaria in Yaounde, Cameroon. Analysis of chloroquine resistance and point mutations in the multidrug resistance (pfmdr 1) gene of Plasmodium falciparum. Am J Trop Med Hyg 59: 577-581.
9. Plowe CV, Cortese JF, Djimde A, Nwanyanwu OC, Watkins WM, Winstanley PA, Estrada-Franco JG, Mollinedo RE, Avila JC, Cespedes JL, Carter D, Doumbo OK, 1997. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. J Infect Dis 176: 1590-1596.
10. Basco LK, Tahar R. Ringwald P, 1998. Molecular basis of in vivo resistance to sulphadoxine-pyrimethamine in African adult patients infected with Plasmodium falciparum malaria parasites. Antimicrob Agents Chemother 42: 1811-1814.
11. Nzila-Mounda A, Mberu EK, Sibley CH, Plowe CV, Winstanley PA, Watkins WM, 1998. Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and Chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain. Antimicroh Agents Chemother 42: 164-169.
12. Tirasophon W, Rajkulchai P, Ponglikitmongkol M, Wilairat P, Boonsaeng V, Panyim S, 1994. A highly sensitive, rapid, and simple polymerase chain reaction-based method to detect human malaria (Plasmodium falciparum and Plasmodium vivax) in blood samples. Am J Trop Med Hyg 51: 308-313.
13. Felger I, Irion A, Steiger S, Beck HP, 1999. Genotypes of merozoite surface protein of Plasmodium falciparum in Tanzania. Trans R Trop Med Hyg 93 (Suppl 1): 3-9.
14. Schmider N, Peyerl-Hoffmann G, Restrepo M, Jelinek T, 2003. Point mutations in the dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum isolates from Colombia. Trop Med Int Health 8: 129-132.
15. Méndez F, Muñoz A, Carrasquilla G, Jurado D, Herrera-Arévalo M, Cortese J, Plowe CV, 2002. Determinants of treatment response to sulfadoxine-pyrimethamine and subsequent transmission potential in falciparum malaria. Am J Epidemiol 156: 230-238.
16. Montoya L, Maetre J, Carmona J, Lopes D, Rosario Do V, Blair S, 2003. Plasmodium falciparum: diversity studies of isolates from two Colombian regions with different endemieity. Exp Parasitol 104: 14-19.
17. Haddad D, Snounou G, Mallei D, Enamorado I, Figueroa J, Stahl S, Berzins K, 1999. Limited genetic diversity of Plasmodium falciparum in field isolates from Honduras. Am J Trop Med Hyg 60: 30-34.
18. Gómez D, Chaparro J, Rubiano C, Rojas MO, Wasseman M, 2002. Genetic diversity of Plasmodium falciparum field isolates from an isolated Colombian village. Am J Trop Med Hyg 67: 611-616.
19. Roll Back Malaria/World Health Organization (WHO), 2001. The use of antimalarial drugs. Report of a WHO informal consultation. Geneva: WHO.
20. Talisuna AO, Bloland P, D́ Alessandro U, 2004. History, dynamics, and public health importance of malaria parasite resistance. Clin Microbiol Rev 17: 235-254.