Analysis of exhaled breath condensate: Potential implications for diagnosis and therapy of lung diseases

New Perspectives in Monitoring Lung Inflammation: Analysis of Exhaled Breath Condensate

Volumn , Issue , 2004, Pages 123-138

  Hatipoğlu, Umur ^a   Rubinstein, Israel ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 28044440858     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (70)

1. Antczak, A. et al., Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients, Eur. Respir. J., 10, 1235, 1997.
2. Antczak, A. et al., Inhaled glucocorticosteroids decrease hydrogen peroxide level in expired air condensate in asthmatic patients, Respir. Med., 94, 416, 2001.
3. Jöbsis, Q. et al., Hydrogen peroxide in exhaled air is increased in stable asthmatic children, Eur. Respir. J., 10, 519, 1997.
4. Dohlman, A.W., Black, H.R., and Royall, J.A., Expired breath hydrogen peroxide is a marker of acute airway inflammation in pediatric patients with asthma, Am. Rev. Respir. Dis., 148, 955, 1993.
5. Horváth, I. et al., Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma, Am. J. Respir. Crit. Care Med., 158, 1042, 1998.
6. Emelyanov, A. et al., Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients, Chest, 120,1136, 2001.
7. Kharitonov, S.A. and Barnes, P.J., Exhaled markers of pulmonary disease, Am. J. Respir. Crit. Care Med., 163, 1693, 2001.
8. Ganas, K. et al., Total nitrites/nitrate in expired breath condensate of patients with asthma, Respir. Med., 95, 649, 2001.
9. Hanazawa, T. et al., Increased nitrotyrosine in exhaled breath condensate of patients with asthma, Am. J. Respir. Crit. Care Med., 162, 1273, 2000.
10. Corradi, M. et al., Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases, Am. J. Respir. Crit. Care Med., 163, 854, 2001.
11. Roberts, L.J. and Morrow, J.D., The isoprostanes: novel markers of lipid peroxidation and potential mediators of oxidative injury, Adv. Prostaglandin Thromboxane Leukotriene Res., 23, 219, 1995.
12. 2-isoprostanes) are formed in situ on phospholipids, Proc. Natl. Acad. Sci. U.S.A., 89, 10721, 1992.
13. Moore, K. and Roberts, L.J., Measurement of lipid peroxidation, Free Radic. Res., 28, 659, 1998.
14. Montuschi, P., et al., Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients, Am. J. Respir. Crit. Care Med., 160, 216, 1999.
15. Antczak, A. et al., Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin induced asthma, Am. J. Respir. Crit. Care Med., 166, 301, 2002.
16. Baraldi, E. et al., Cysteinyl leukotrienes and 8-isoprostane in exhaled breath condensate of children with asthma exacerbations, Thorax, 58, 505, 2003.
17. Montuschi, P. and Barnes, P.J., Exhaled leukotrienes and prostaglandins in asthma, J. Allergy Clin. Immunol., 109,615, 2002.
18. Csoma, Z. et al., Increased leukotrienes in exhaled breath condensate in childhood asthma, Am. J. Respir. Crit. Care Med., 166, 1345, 2002.
19. Corradi, M. et al., Aldehydes and glutathione in exhaled breath condensate of children with asthma exacerbation, Am. J. Respir. Crit. Care Med., 167, 395, 2003.
20. Effros, R.M. et al., Dilution of respiratory solutes in exhaled condensate, Am. J. Respir. Crit. Care Med., 165, 663, 2002.
21. Hunt, J.F. et al., Endogenous airway acidification: implications for asthma pathophysiology, Am. J. Respir. Crit. Care Med., 161, 694, 2000.
22. Kostikas, K. et al., pH in expired breath condensate of patients with inflammatory airway diseases, Am. J. Respir. Crit. Care Med., 165, 1364, 2002.
23. Huszár, É. Et al., Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma, Eur. Respir. J., 20, 1393, 2002.
24. Shahid, S.K. et al., Increased interleukin-4 and decreased interferon-γ in exhaled breath condensate of children with asthma, Am. J. Respir. Crit. Care Med., 165, 1290, 2002.
25. Sandrini, A. et al., Effect of nasal triamcinolone acetonide on lower airway inflammatory markers in patients with allergic rhinitis, J. Allergy Clin. Immunol., 111, 313, 2003.
26. Dekhuijzen, P.N.R. et al., Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 154, 813, 1996.
27. Ferreira Martens, I. et al., Exhaled nitric oxide and hydrogen peroxide in patients with chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 164, 1012, 2001.
28. Van Beurden, W.J.C. et al., Effects of inhaled corticosteroids with different lung deposition on exhaled hydrogen peroxide in stable COPD patients, Respiration, 70, 242, 2003.
29. Kasielski, M. and Nowak, D., Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease, Respir. Med., 95, 448, 2001.
30. Montuschi, P. et al., Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers, Am. J. Respir. Crit. Care Med., 162, 1175, 2000.
31. 4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD, Thorax, 58, 294, 2003.
32. Corradi, M. et al., Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 167, 1380, 2003.
33. Montuschi, P. et al., Exhaled leukotrienes and prostaglandins in COPD. Thorax, 58, 585, 2003.
34. Nowak, D. et al., Increased content of hydrogen peroxide in the expired breath of cigarette smokers, Eur. Respir. J., 9, 652, 1996.
35. Blue, M.L. and Janoff, A., Possible mechanisms of emphysema in cigarette smokers:release of elastase from human polymorphonuclear leukocytes by cigarette smoke condensate in vitro, Am. Rev. Respir. Dis., 117,317, 1978.
36. Guatura, S.B. et al., Increased exhalation of hydrogen peroxide in healthy subjects following cigarette consumption, Sao Paolo Med. J., 118, 93, 2000.
37. Nowak, D. et al., Cigarette smoking does not increase hydrogen peroxide levels in expired breath condensate of patients with stable COPD, Monaldi Arch. Chest Dis., 53, 268, 1998.
38. Carpagnano, G.E. et al., Increased inflammatory markers in the exhaled breath condensate of cigarette smokers, Eur. Respir. J., 21, 589, 2003.
39. Garey, K.W. et al., Markers of inflammation in exhaled breath condensate of young healthy smokers, Chest, 125, 22, 2004.
40. Corradi, M., Pesci, A., and Casana, R., Nitrates in exhaled breath condensate of patients with different airway diseases, Nitric Oxide, 8, 26, 2003.
41. Loukides, S. et al., Elevated levels of expired breath hydrogen peroxide in bronchiectasis, Am. J. Respir. Crit. Care Med., 158, 991, 1998.
42. 2 in steady-state bronchiectasis: relationship with cellular composition in induced sputum, spirometry, and extent and severity of disease, Chest, 121, 81, 2002.
43. Ho, L.P. et al., Expired hydrogen peroxide in breath condensate of cystic fibrosis patients, Eur. Respir. J., 13, 103, 1999.
44. Jöbsis, Q. et al., Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment, Eur. Respir. J., 16, 95, 2000.
45. Ho, L.P., Innes, J.A., and Greening, A.P., Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast exhaled nitric oxide, Thorax, 53, 680, 1998.
46. Cunningham, S. et al., Measurement of inflammatory markers in the breath condensate of children with cystic fibrosis, Eur. Respir. J., 15, 955, 2000.
47. 4 and interleukin-6 in exhaled breath condensate in cystic fibrosis, Am. J. Respir. Crit. Care Med., 167, 1109, 2003.
48. Montuschi, P. et al., Exhaled 8-isoprostane as new non-invasive biomarker of oxidative stress in cystic fibrosis, Thorax, 55, 205, 2000.
49. Balint, B. et al., Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis, Eur. Respir. J., 17, 1201, 2001.
50. Tate, S. et al., Airways in cystic fibrosis are acidified: detection by exhaled condensate, Thorax, 57, 926, 2002.
51. Smith, J.J. and Welsh, M.J., cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia, J. Clin. Invest., 89, 1148, 1992.
52. Baldwin, S.R. et al., Oxidant activity in expired breath of patients with adult respiratory distress syndrome, Lancet, 1, 11, 1986.
53. Sznajder, J.I. et al., Increased hydrogen peroxide in the expired breath of patients with acute hypoxemia respiratory failure, Chest, 96, 606, 1989.
54. Kietzman, D. et al., Hydrogen peroxide in expired breath condensate of patients with acute respiratory failure and with ARDS, Intensive Care Med., 19, 78, 1993.
55. Carpenter, C.T., Price, P.V., and Christman, B.W., Exhaled breath condensate isoprostanes are elevated in patients with acute lung injury or ARDS, Chest, 114, 1653, 1998.
56. 1 on hydrogen peroxide concentrations in the exhaled breath of patients with the acute respiratory distress syndrome, Anesth. Analg., 89, 353, 1999.
57. Ranieri, V.M. et al., Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial, JAMA, 1282, 54, 1999.
58. Scheideler, L. et al., Detection of nonvolatile macromolecules in breath, Am. Rev. Respir. Dis., 148, 774, 1993.
59. Montuschi, P. et al., 8-isoprostane as a biomarker of oxidative stress in interstitial lung diseases, Am. J. Respir. Crit. Care Med., 158, 1524, 1998.
60. Luczynska, M. et al., Elevated exhalation of hydrogen peroxide in patients with systemic sclerosis, Eur. J. Clin. Invest., 33, 274, 2003.
61. Carpagnano, G.E. et al., Increased vitronectin and endothelin-1 in the breath condensate of patients with fibrosing lung disease, Respiration, 70, 154, 2003.
62. Ziesche, R. et al., A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisone in patients with idiopathic pulmonary fibrosis, N. Engl. J. Med., 341, 1264, 1999.
63. Hatipŏglu, U. and Rubinstein, I., Inflammation and obstructive sleep apnea syndrome pathogenesis: a working hypothesis, Respiration, 70, 665, 2003.
64. Carpagnano, G.E. et al., Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients, Chest, 122, 1162, 2002.
65. Carpagnano, G.E. et al., Interleukin-6 is increased in breath condensate of patients with non small cell lung cancer, Int. J. Biol. Markers, 17, 141, 2002.
66. Nayeri, F. et al., Exhaled breath condensate and serum levels of hepatocyte growth factor in pneumonia, Respir. Med., 96,115. 2002.
67. Jöbsis, R.Q. et al., Hydrogen peroxide in breath condensate during a common cold, Mediators Inflamm., 10, 351, 2001.
68. Schreiber, J. et al., Mycobacterium tuberculosis gene amplification in breath condensate of patients with lung tuberculosis, Eur. J. Med. Res., 7, 290, 2002.
69. Silkoff, P.E., et al., Exhaled nitric oxide in human lung transplantation, Am. J. Crit. Care Med., 157, 1822, 1998.
70. Lases, E.C. et al., Oxidative stress after lung resection therapy: A pilot study, Chest, 117, 999, 2000.